Expression of angiostatic platelet factor-4var/CXCL4L1 counterbalances angiogenic impulses of vascular endothelial growth factor, interleukin-8/CXCL8, and stromal cell-derived factor 1/CXCL12 in esophageal and colorectal cancer

Verbeke, Hannelien; Hertogh, Gert De; Li, Sandra; Vandercappellen, Jo; Noppen, Sam; Schutyser, Evemie; El-Asrar, Ahmed Abu; Opdenakker, Ghislain; Damme, Jozef Van; Geboes, Karel; Struyf, Sofie

doi:10.1016/j.humpath.2009.09.021

Cited by 23 publications

(18 citation statements)

References 32 publications

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“…Interestingly, not only was the expression of the angiogenic chemokines CXCL8 and CXCL12 heterogeneous in the samples, but so was the expression of the angiostatic chemokines CXCL10 and CXCL4L1. Based on these results, the roles of chemokines are likely complex in these tumors [115] . Recently, in vitro and in vivo studies using AMD3100, a pharmacological CXCR4 inhibitor, and the human HER2 inhibitor, trastuzumab, have indicated CXCR4 to be a positive regulator of human epidermal growth factor receptor 2 (HER2) expression in esophageal cancer.…”

Section: Esophagusmentioning

confidence: 94%

“…In addition, full-length and N-terminally truncated (more active) CXCL8 was identified in HT-29 colorectal adenocarcinoma cells, as well as strong expression of CXCL4L1 and CXCL12 in patient samples [115] . Moreover, ERK2 and PI-3K/AKT have been identified as candidate pathways for induction of CXCL8 expression in HCT-15 colon cancer cells and MKN-45 gastric adenocarcinoma cells [178] .…”

Section: Small and Large Intestinementioning

confidence: 97%

“…Moreover, chemokine expression in tumors is complicated. Verbeke et al [115] screened 51 patients operated on for colon adenocarcinoma, esophageal adenocarcinoma, or esophageal squamous cell carcinoma (SCC) by immunohistochemical staining to examine the expression of CXCL4L1, CXCL8, CXCL10, CXCL12, and VEGF. According to their study, the angiostatic chemokine CXCL4L1 was strongly expressed in colorectal cancer, while there was weaker expression in esophageal cancer.…”

Section: Esophagusmentioning

confidence: 99%

“…In colorectal adenocarcinoma cells HCT-116 and HCT-8, immunohistochemistry revealed that diverse stimuli can upregulate CXCL8 expression [115] , with upregulation of CXCL4L1 and synergistic CXCL8 and CXCL10 induction in carcinoma cells by IL-1 and TNF-α or immunoreactive fibronectin. In addition, full-length and N-terminally truncated (more active) CXCL8 was identified in HT-29 colorectal adenocarcinoma cells, as well as strong expression of CXCL4L1 and CXCL12 in patient samples [115] .…”

Section: Small and Large Intestinementioning

confidence: 99%

“…Perineural invasion and dissemination of neoplastic cells along intra-and extra-pancreatic nerves [163,164] CXCL17 (+ ICAM2) Diagnostic molecular marker [167] CXCL7 (+ CA19-9) Diagnostic molecular marker [168] Colon CXCL4L1 Upregulation in colorectal cancer [115] CCL2 upregulation in mucosa of IBD [169] …”

Section: Cx3cl1cx3cr1mentioning

confidence: 99%

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Chemokines, chemokine receptors and the gastrointestinal system

Miyazaki¹,

Takabe²,

Yeudall³

2013

WJG

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Core tip: The chemokine network makes an attractive target for therapeutic intervention in many tumor types, including those of the gastrointestinal tract. However, we need to define more selective and specific targets, to minimize systemic side effects during treatment. INTRODUCTION Cancer development and progression in the gastrointestinal tractCancer is a disease in which normal cells acquire genetic and epigenetic abnormalities [1,2] , leading to disorientation of conventional processes for the maintenance of normal cell physiology. These aberrant genetic and epigenetic modifications to the normal cell induce abnormal cell motility, proliferation, and survival, eventually enabling these cells to invade into adjacent tissues and even to migrate to regional or distant organs where they may grow continuously as metastatic lesions [3] . For many cancer patients, metastasis is generally the major cause of disease-related death [4,5] . Therefore, it is indispensable to elucidate the basic molecular mechanisms of tumor development to identify effective therapeutic targets, which can possibly reduce the side-effects of treatment, and define useful molecular markers for early detection and prediction of disease course. Especially, the newly emerged concept of personalized medicine may require in-depth assessment of potential therapeutic molecular target(s) in each individual case through analysis of sig- REVIEW Chemokines, chemokine receptors and the gastrointestinal system AbstractThe biological properties of tumor cells are known to be regulated by a multitude of cytokines and growth factors, which include epidermal growth factor receptor agonists and members of the transforming growth factor β family. Furthermore, the recent explosion of research in the field of chemokine function as mediators of tumor progression has led to the possibility that these small, immunomodulatory proteins also play key roles in carcinogenesis and may, therefore, be potential targets for novel therapeutic approaches. In this review, we will summarize recently reported findings in chemokine biology with a focus on the gastrointestinal tract.

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Section: Esophagusmentioning

confidence: 94%

Section: Small and Large Intestinementioning

confidence: 97%

Section: Esophagusmentioning

confidence: 99%

Section: Small and Large Intestinementioning

confidence: 99%