Expression of c-Fos in rat auditory and limbic systems following 22-kHz calls

Ouda, Ladislav; Jilek, Milan; Syka, Josef

doi:10.1016/j.bbr.2016.04.030

Cited by 34 publications

(35 citation statements)

References 57 publications

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“…In the BLA, a robust increase in cFos density was observed in response to 22kHz USV playback when compared to both silence and 55kHz USV playback. This finding is supported by previous work indicating that 22kHz, but not 55kHz, USV playback increases overall BLA activation compared to non-social stimuli and/or silence (Ouda et al, 2016;Sadananda et al, 2008). BLA activity has been shown to be indicative of anxiety-like states in the rat (Davis and Whalen, 2001;Vyas et al, 2004;Daskalakis et al, 2014), and therefore this change could be an index of induced anxiety in response to a socially-relevant aversive stimulus.…”

Section: Khz Usvs Mediate Cfos In Brain Regions Associated With Anxsupporting

confidence: 85%

“…Studies employing playback of USVs have revealed changes in brain activity in key brain regions associated with anxiety. These studies have reported significant increases in neural activation (assessed via cFos) in brain regions important for emotional valence, including the basolateral amygdala (BLA), periaqueductal grey, and the hippocampus (Sadananda et al, 2008;Ouda et al, 2016). Furthermore, research by Parsana and colleagues (2012) show that single-unit recordings of amygdala neuron activity differ depending on the type of USV playback, with an increased rate of firing associated with 22kHz USVs, and a tonic decrease in firing rate associated with 55kHz USVs.…”

Section: Introductionmentioning

confidence: 99%

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22 kHz and 55 kHz ultrasonic vocalizations differentially influence neural and behavioral outcomes: Implications for modeling anxiety via auditory stimuli in the rat

Demaestri

Brenhouse

Ganguly

2019

Behavioural Brain Research

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The communicative role of ultrasonic vocalizations (USVs) in rats is well established, with distinct USVs indicative of different affective states. USVs in the 22kHz range are typically emitted by adult rats when in anxiety-or fear-provoking situations (e.g. predator odor, social defeat), while 55kHz range USVs are typically emitted in appetitive situations (e.g., play, anticipation of reward). Previous work indicates that USVs (real-time and playback) can effectively communicate these affective states and influence changes in behavior and neural activity of the receiver. Changes in cFos activation following 22kHz USVs have been seen in cortical and limbic regions involved in anxiety, including the basolateral amygdala (BLA). However, it is unclear how USV playback influences cFos activity within the bed nucleus of the stria terminalis (BNST), a region also thought to be critical in processing anxiety-related information, and the nucleus accumbens, a region associated with reward. The present work sought to characterize distinct behavioral, physiological, and neural responses in rats presented with aversive (22kHz) compared to appetitive (55kHz) USVs or silence. Our findings show that rats exposed to 22kHz USVs: 1) engage in anxiety-like behaviors in the elevated zero maze, and 2) show distinct patterns of cFos activation within the BLA and BNST that contrast those seen in 55kHz playback and silence. Specifically, 22kHz USVs increased cFos density in the anterodorsal nuclei, while 55kHz playback increased cFos in the oval nucleus of the BNST, without significant changes within the nucleus accumbens. These results provide important groundwork for leveraging ethologically-relevant stimuli in the rat to improve our understanding of anxiety-related responses in both typical and pathological populations.

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Section: Khz Usvs Mediate Cfos In Brain Regions Associated With Anxsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

22 kHz and 55 kHz ultrasonic vocalizations differentially influence neural and behavioral outcomes: Implications for modeling anxiety via auditory stimuli in the rat

Demaestri

Brenhouse

Ganguly

2019

Behavioural Brain Research

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“…When under duress or when in the presence of danger, most vertebrate species produce sounds that (among other functions) serve to advertise the ongoing discomfort situation. Calls uttered in distress circumstances are known as “distress calls”, “alarm calls”, or “screams”234567891011, and they have profound effects in the listeners’ physiology and behaviour, such as boosting gene expression, elevating heart-rate, activating the neuroendocrine axis, and evoking exploratory and mobbing behaviours in conspecifics5679101213141516171819202122.…”

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confidence: 99%

Vocal sequences suppress spiking in the bat auditory cortex while evoking concomitant steady-state local field potentials

Hechavarría

Beetz

Macías

et al. 2016

Sci Rep

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The mechanisms by which the mammalian brain copes with information from natural vocalization streams remain poorly understood. This article shows that in highly vocal animals, such as the bat species Carollia perspicillata, the spike activity of auditory cortex neurons does not track the temporal information flow enclosed in fast time-varying vocalization streams emitted by conspecifics. For example, leading syllables of so-called distress sequences (produced by bats subjected to duress) suppress cortical spiking to lagging syllables. Local fields potentials (LFPs) recorded simultaneously to cortical spiking evoked by distress sequences carry multiplexed information, with response suppression occurring in low frequency LFPs (i.e. 2–15 Hz) and steady-state LFPs occurring at frequencies that match the rate of energy fluctuations in the incoming sound streams (i.e. >50 Hz). Such steady-state LFPs could reflect underlying synaptic activity that does not necessarily lead to cortical spiking in response to natural fast time-varying vocal sequences.

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“…The perception of vocal signals can be lateralized in the auditory cortex, though in some cases this lateralization is context‐ and call‐specific (Geissler & Ehret, 2004; Heffner & Heffner, 1984; Sadananda, Wöhr, & Schwarting, 2008; Taglialatela, Russell, Schaeffer, & Hopkins, 2009). In regions outside the temporal cortex, lateralized responses during perception are largely absent (Geissler, Sabine Schmidt, & Ehret, 2013; Ouda, Jílek, & Syka, 2016).…”

Section: Introductionmentioning

confidence: 99%

Call‐specific patterns of neural activation in auditory processing of Richardson’s ground squirrel alarm calls

2020

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Expression of c-Fos in rat auditory and limbic systems following 22-kHz calls

Cited by 34 publications

References 57 publications

22 kHz and 55 kHz ultrasonic vocalizations differentially influence neural and behavioral outcomes: Implications for modeling anxiety via auditory stimuli in the rat

22 kHz and 55 kHz ultrasonic vocalizations differentially influence neural and behavioral outcomes: Implications for modeling anxiety via auditory stimuli in the rat

Vocal sequences suppress spiking in the bat auditory cortex while evoking concomitant steady-state local field potentials

Call‐specific patterns of neural activation in auditory processing of Richardson’s ground squirrel alarm calls

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