Expression of Concern to: The role of ACE2, angiotensin-(1–7) and Mas1 receptor axis in glucocorticoid-induced intrauterine growth restriction

Ghadhanfar, Elham; Alsalem, Aseel; Al-Kandari, Shaimaa; Naser, Jumana; Babiker, Fawzi; Al‐Bader, Maie

doi:10.1186/s12958-020-00609-9

Search citation statements

Order By: Relevance

Paper Sections

Select...

Direct Effects Of Srs In Lung Cells and Their Role In Covid Infections1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2021

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There may be an aspect of GR signalling affecting viral entry into lung cells as well. Dexamethasone has been reported in mouse placental studies to inhibit ACE2 expression [ 132 , 133 ]. In mouse and human COPD models, inhaled corticosteroids were reported to inhibit ACE expression but no change in TMPRSS2 expression was associated with their use [ 134 ].…”

Section: Direct Effects Of Srs In Lung Cells and Their Role In Covid Infectionsmentioning

confidence: 99%

Roles of steroid receptors in the lung and COVID-19

Leach

Brooke

Bevan

2021

Essays in Biochemistry

View full text Add to dashboard Cite

COVID-19 symptoms and mortality are largely due to its devastating effects in the lungs. The disease is caused by the SARS (Severe Acute Respiratory Syndrome)-CoV-2 coronavirus, which requires host cell proteins such as ACE2 (angiotensin-converting enzyme 2) and TMPRSS2 (transmembrane serine protease 2) for infection of lung epithelia. The expression and function of the steroid hormone receptor family is important in many aspects that impact on COVID-19 effects in the lung – notably lung development and function, the immune system, and expression of TMPRSS2 and ACE2. This review provides a brief summary of current knowledge on the roles of the steroid hormone receptors [androgen receptor (AR), glucocorticoid receptor (GR), progesterone receptor (PR), mineralocorticoid receptor (MR) and oestrogen receptor (ER)] in the lung, their effects on host cell proteins that facilitate SARS-CoV-2 uptake, and provides a snapshot of current clinical trials investigating the use of steroid receptor (SR) ligands to treat COVID-19.

show abstract

Section: Direct Effects Of Srs In Lung Cells and Their Role In Covid Infectionsmentioning

confidence: 99%