Expression of Endoglin (CD-105) and Microvessel Density in Oral Dysplasia and Squamous Cell Carcinoma

Basnaker, Maharudrappa; Bnvs, Satish

doi:10.7860/jcdr/2014/9429.4904

Cited by 7 publications

(6 citation statements)

References 22 publications

(17 reference statements)

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“…This suggests that the angiogenic phenotypic change could occur mainly in OSCC rather than OED. 9 Other authors such as Sathyakumar et al 32 Basnaker et al 33 also studied MVD in samples with NOM, OED and OSCC diagnoses, but used different types of markers for blood vessels. However, it should be noted that most of the studies, independent of the marker used, coincide with the results of this study in relation to the increase in MDV in the transition from NOM to OED to OSCC.…”

mentioning

confidence: 99%

Difference in EGFR expression and mean vascular density in normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma.

Fernández¹,

Fernández

Marshall

et al. 2017

J Oral Res

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To evaluate the expression of the epidermal growth factor receptor (EGFR) and mean vascular density (MVD) in normal oral mucosa (NOM), oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). Material and methods: Descriptive case study. Nineteen histological samples diagnosed with NOM, 18 diagnosed with OED, and 19 with OSCC, were analyzed with immunohistochemistry against EGFR and CD31. EGFR expression was evaluated by extent and intensity of its expression in normal, dysplastic and neoplastic epithelium. MVD was determined through the detection of blood vessels by antibodies against CD31. Results: Extension of EGFR expression was highest in OSCC followed by OED and lowest in NOM, resulting in significant different between the degrees of extension (p<0.001). Intensity of EGFR was similar in NOM, OED and OSCC, without differences in its expression (p=0.533). Differences in MVD were found between NOM and OSCC groups (p<0.01), and between OED and OSCC groups (p<0.01), with no differences between NOM and OED groups (p=0.91). MVD was 21.17±4.98 in NOM, 23.40±5.77 in OED and 33.92±8.39 in OSCC. Conclusion: EGFR is expressed in normal, dysplastic or neoplastic oral epithelium. However, the extent of its expression is greater as malignancy increases. MVD varies according to the diagnosis.

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mentioning

confidence: 99%

Difference in EGFR expression and mean vascular density in normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma.

Fernández¹,

Fernández

Marshall

et al. 2017

J Oral Res

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“…The assessment criteria were based on previous studies. [18][19][20]23,25,26 The standardization of the examiners showed a kappa index of 0.88.…”

Section: Methodsmentioning

confidence: 99%

“…19,20,22 The quantification of the expression of this protein has been proposed to evaluate neoangiogenesis in different types of tumors. 21,23 On the other hand, microvascular density (MVD) is a useful histomorphological parameter to evaluate tumor angiogenesis, which is considered an indicator of tumor growth, and has been correlated with the aggressive behavior of tumors. 17,20,22 The aim of this study was to compare the MVD in OM and dental follicle (DF) based on the expression of CD-105, in an effort to obtain new information that may contribute to understand the possible pathogenic mechanisms implicated in the growth of this neoplasm.…”

Section: Introductionmentioning

confidence: 99%

Assessment of CD-105 as an Angiogenic Modulator in Odontogenic Myxomas and Dental Follicles

et al. 2016

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Aim Odontogenic myxoma is a benign intraosseous neoplasm of the jaws, with a locally aggressive behavior and a high recurrence rate. CD-105 is a homodimeric cell membrane glycoprotein and is a component of the TGF-β1 growth factor receptor complex that modulates angiogenesis by regulating the proliferation, differentiation and cellular migration. The aim of this study is to quantify the microvascular density of the odontogenic myxoma based on the expression of CD-105. Materials and Methods The analysis included 18 odontogenic myxoma and 18 dental follicles as controls. A standard immunohistochemical procedure was performed with the CD-105 antibody. Five representative fields (40×) of the odontogenic myxoma and the dental follicles were selected to determine the microvascular density, which was then followed by a descriptive and comparative statistical analysis. Results Dental follicles presented a significantly higher microvascular density compared with odontogenic myxoma (P = .001). The odontogenic myxoma smaller than 3 cm showed a greater microvascular density than those larger than 3 cm in size (P > .05), and the microvascular density was lower in large odontogenic myxomas as compared with the dental follicles (P = .003). Conclusion A weaker expression of CD-105 in odontogenic myxoma might indicate a lower angiogenic activity, suggesting that vascular proliferation has a limited role in the growth mechanisms and in the aggressive behavior of this neoplasm.

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“…9,10 While studies have been conducted investigating angiogenic markers in OSCC, contradictory results have been reported in the literature. 8,[11][12][13][14][15] The objective of this study was therefore to analyze immunohistochemical expression of CD105 and of vWF in a series of cases of OSCC and determine whether angiogenic indices exhibit correlations with clinicopathological parameters of the tumors. The intention is to thereby contribute to improved understanding of the biological behavior of OSCC and to evaluate the potential role of the proteins tested as markers of tumor progression.…”

Section: Introductionmentioning

confidence: 99%

Expressão imunoistoquímica da endoglina (CD105) e do fator de von Willebrand em carcinoma epidermoide oral e sua relação com parâmetros clinicopatológicos

et al. 2016

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Resumo Contexto A angiogênese tem sido associada à progressão de neoplasias malignas e, embora haja estudos acerca de marcadores angiogênicos no carcinoma epidermoide oral (CEO), existem resultados conflitantes na literatura. Objetivos Avaliar a expressão imunoistoquímica do CD105 e do fator de von Willebrand (FvW) em CEO e sua relação com parâmetros clínicos do tumor. Métodos A imunoexpressão dos referidos biomarcadores foi analisada em 30 casos de CEO e correlacionada a parâmetros clínicos do tumor (idade e sexo dos pacientes, localização anatômica e estadiamento clínico Tumor, Nodo e Metástase, TNM). Resultados A imunomarcação com o anticorpo anti-FvW foi mais efetiva que a do CD105 no CEO. No que concerne à localização anatômica, o assoalho bucal e a região retromolar apresentaram diferenças estatisticamente significativas quanto aos índices angiogênicos (p = 0,004), determinados pela técnica de contagem microvascular (MVC). Não houve relação estatisticamente significativa entre o estadiamento clínico TNM e os índices angiogênicos, com os dois biomarcadores. Conclusões Com base nos achados deste estudo, sugere-se um envolvimento da neoformação vascular na carcinogênese oral, embora não tenha sido evidenciada associação significativa com o estágio clínico da lesão.

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Expression of Endoglin (CD-105) and Microvessel Density in Oral Dysplasia and Squamous Cell Carcinoma

Cited by 7 publications

References 22 publications

Difference in EGFR expression and mean vascular density in normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma.

Difference in EGFR expression and mean vascular density in normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma.

Assessment of CD-105 as an Angiogenic Modulator in Odontogenic Myxomas and Dental Follicles

Expressão imunoistoquímica da endoglina (CD105) e do fator de von Willebrand em carcinoma epidermoide oral e sua relação com parâmetros clinicopatológicos

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