Expression of fibroblast growth factor-β and transforming growth factor-β in mauli banana stem (Musa Acuminate) extract gel - treated traumatic ulcer

Apriasari, Maharani Laillyza; Pramitha, Selviana Rizky; Puspitasari, Dewi; Ernawati, Diah Savitri

doi:10.4314/tjpr.v18i3.12

Cited by 4 publications

(3 citation statements)

References 11 publications

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“…In this study, catalpol suppressed cell proliferation, migration and EMT of TGF-β2stimulated SRA01/04, suggesting the possibility that catalpol might be a potential agent for PCO. The TGF-β pathway is an inducer of EMT, and TGF-β2-stimulated LECs have been widely used as model of PCO [10,11]. In this study, TGF-β2 was used to induce an increase of cell proliferation and migration in SRA01/04.…”

Section: Discussionmentioning

confidence: 99%

Catalpol represses the migration, proliferation and epithelial mesenchymal transition of TGF β2 stimulated lens epithelial cells via TGF β/Smad and Notch1 signaling pathways

Li¹,

Ma²

2022

Trop. J. Pharm Res

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Purpose: To investigate the role of catalpol in posterior capsule opacification (PCO). Methods: Human lens epithelial cells (SRA01/04) were treated with TGF-β2 or co-treated with TGF-β2 and different concentrations of catalpol. Cell migration and viability were assessed via wound healing and CCK8, respectively. Epithelial- esenchymal transition and the underlying mechanism of action were evaluated using western blot. Results: Treatment with TGF-β2 significantly increased cell viability and promoted the migration of SRA01/04 (p < 0.001). However, catalpol significantly reduced cell viability and repressed the migration of TGF-β2-stimulated SRA01/04 (p < 0.001). Moreover, TGF-β2-stimulated increases in fibronectin, α-smooth muscle actin (α-SMA), snail and vimentin. Decreases of E-cadherin and connexin-43 in SRA01/04 were reversed by catalpol. Moreover, TGF-β2-stimulated the up-regulation of p-smad2/3, while SRA01/04 was down-regulated by catalpol, but attenuated TGF-β2-stimulated increases in Notch1 and Jagged1 in SRA01/04. Conclusion: Catalpol inhibits TGF-β2-stimulated migration, proliferation and epithelial- esenchymal transition of SRA01/04 through the inactivation of TGF-β/Smad and Notch1 signaling. Catalpol might be a novel preventive agent for PCO. However, the effect of catalpol on animal models of PCO should be investigated further.

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Section: Discussionmentioning

confidence: 99%

Catalpol represses the migration, proliferation and epithelial mesenchymal transition of TGF β2 stimulated lens epithelial cells via TGF β/Smad and Notch1 signaling pathways

Li¹,

Ma²

2022

Trop. J. Pharm Res

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“…MB has a tannin content of 67%, and the tannins found in bananas are condensed tannins or proanthocyanidins. 13,16,26 Proanthocyanidins effectively strengthen the collagen fiber matrix, which is the organic matrix of dentin, and keep collagen fibers from degradation. 27 Proanthocyanidins can inhibit demineralization by reducing collagen degradation by dentine proteases, inhibiting proteolytic activity, and protecting dentin from enzymatic degradation.…”

Section: Discussionmentioning

confidence: 99%

Demineralized dentin characteristics after application of Mauli banana stem gel

Carabelly,

Puspitasari,

Syahrina

et al. 2024

Dent. J.

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Background: Demineralization of dentin is a condition of dissolving minerals in peritubular dentin due to exposure to acids that release hydroxyapatite ions. To prevent dentin demineralization, a therapeutic agent that can inhibit the dissolution ability of hydroxyapatite ions is needed. One therapeutic agent that can be used is the Mauli banana (MB) stem gel. Purpose: To observe the characteristics of dentin demineralization after the use of MB stem extract gel. Method: Mandibular incisor bovine teeth were demineralized with lactic acid pH 4.5 for 72 hours and then treated with 25%; 37.5%; 50%; and 62.5% MB gel and Chlorhexidine 2% for one minute. All samples were soaked in artificial saliva with 1 mg/ml saliva of collagenase enzyme for 24 hours. The characteristic of dentin demineralization was observed by using scanning electron microscope/electron dispersive X-ray spectroscopy (SEM-EDX). Results: The SEM image in the control, Chlorhexidine, 25%; 37.5%; 50%; and 62.5% MB gel groups showed dentinal tubules of about 3.67–4.94 µm; 3.55–4 µm; 4.18–5.6 µm; 2.28–2.86 µm; 3.29–3.81 µm; and 2.42–3.17 µm in size. The EDX test found carbon (C), nitrogen (N), oxygen (O), sodium (Na), phosphorous (P), chlorine (Cl), and calcium (Ca) in all groups. The one-way Analysis of Variance (ANOVA) test results showed significant differences in the levels of C, N, O, Cl, and Ca between all groups, while the Na showed no significant differences. Conclusion: The MB can inhibit the demineralization of bovine dentin based on the decrease in the size of the dentinal tubules and increasing the C, O, P, and Ca.

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“…The mucosa epithelium thickened to its maximum on the seventh day. Thus, it was determined that 25% of ethanol extract on Mauli bananas might fasten the thickness of the mouth mucosa during the healing process [17].…”

Section: Wound Healing Propertymentioning

confidence: 99%

Pharmacological Properties of Banana Stem: An Updated Review

et al. 2022

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Musaceae is a perennial tree-like plant that is cultivated all over the world in various tropical and subtropical regions. The fruit, peel, leaves, pseudo-stem, stalk, and inflorescence (flower) of this plant, among other parts, are utilized in traditional medicine to treat several health problems. The banana stem juice has potential biological effects, including anti-diabetic, anti-inflammatory, anti-microbial, anti-helminthic, wound-healing, anti-cancer, anti-oxidant, and anti-urolithic activities. Consequently, it can be said that banana stem juice contains adequate levels of healthy secondary metabolites that are essential for maintaining good health. To find novel approaches for treating and preventing a wide range of medical diseases, more studies into the medicinal potential of banana stem juice can be done. Hence, this review emphasizes Musaceae stem juice's medicinal and nutritional benefits as review.

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Expression of fibroblast growth factor-β and transforming growth factor-β in mauli banana stem (Musa Acuminate) extract gel - treated traumatic ulcer

Cited by 4 publications

References 11 publications

Catalpol represses the migration, proliferation and epithelial mesenchymal transition of TGF β2 stimulated lens epithelial cells via TGF β/Smad and Notch1 signaling pathways

Catalpol represses the migration, proliferation and epithelial mesenchymal transition of TGF β2 stimulated lens epithelial cells via TGF β/Smad and Notch1 signaling pathways

Demineralized dentin characteristics after application of Mauli banana stem gel

Pharmacological Properties of Banana Stem: An Updated Review

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