Expression of Frizzled10 in mouse central nervous system

Yan, Yan; Li, Yiping; Hu, Chuanyin; Gu, Xiaofeng; Liu, Junhua; Hu, Yuan; Yang, Yang; Wei, Yiquan; Zhao, Chunjie

doi:10.1016/j.gep.2008.11.001

Cited by 11 publications

(10 citation statements)

References 15 publications

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“…Previous reports demonstrate that FZD10 is expressed in the developing tail bud, limb buds, and central nervous system in a number of model systems (Borello et al, ; Chesnutt et al, ; Deardorff et al, ;, Endo et al, ; Garcia‐Morales et al, ; Kawakami et al, ; McCabe et al, ; Nunnally and Parr, ; Paxton et al, ; Stenman et al, ; Summerhurst et al, ; Yan et al, ). We were particularly interested in the expression of FZD10 in the dorsal spinal cord, which suggested a possible role in mediating WNT1 and WNT3A signaling.…”

Section: Resultsmentioning

confidence: 99%

“…These data suggest possible roles for FZD10 the development of the dorsal spinal cord. However, as Fzd10 knockout mice have no overt phenotype (Mouse Genome Database: MGI: 2136761), it seems likely that at least one other Frizzled family member can compensate for the loss of FZD10 (Borello et al, ; Bourhis et al, ; Deardorff et al, ; Endo et al, ; Hollyday et al, ; Janda et al, ; Kawakami et al, ; Nunnally and Parr, ; Parr et al, , Summerhurst et al, ; Tamai et al, ; Wang et al, ; Yan et al, ). Though FZD4 and 9 are the most closely related to FZD10, neither has been linked to dorsal spinal cord development.…”

Section: Resultsmentioning

confidence: 99%

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Frizzled10 mediates WNT1 and WNT3A signaling in the dorsal spinal cord of the developing chick embryo

Galli

Munji

Chapman

et al. 2014

Developmental Dynamics

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Background WNT1 and WNT3A drive a dorsal to ventral gradient of β-catenin dependent Wnt signaling in the developing spinal cord. However, the identity of the receptors mediating downstream functions remains poorly understood. Results In this paper, we show that the spatiotemporal expression patterns of FZD10 and WNT1/WNT3A are highly correlated. We further show that in the presence of LRP6, FZD10 promotes WNT1 and WNT3A signaling using an 8xSuperTopFlash reporter assay. Consistent with a functional role for FZD10, we demonstrate that FZD10 is required for proliferation in the spinal cord. Finally, by using an in situ proximity ligation assay, we observe an interaction between FZD10 and WNT1 and WNT3A proteins. Conclusion Together, our results identify FZD10 as a receptor for WNT1 and WNT3A in the developing chick spinal cord.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Frizzled10 mediates WNT1 and WNT3A signaling in the dorsal spinal cord of the developing chick embryo

Galli

Munji

Chapman

et al. 2014

Developmental Dynamics

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“…However, in synovial sarcomas, the transactivation of FZD 10 , which is highly up‐regulated in synovial sarcomas, can be linked to the β‐catenin‐independent DVL‐Rac1‐JNK pathway and plays a critical role in the development/progression of synovial sarcomas (Fukukawa et al ., ). Furthermore, an enhanced expression of FZD 10 occurs during embryonic development of the CNS (Yan et al ., ).…”

Section: Wnt Binding To Fzd and Physiological Relevancementioning

confidence: 97%

“…Furthermore, an enhanced expression of FZD10 occurs during embryonic development of the CNS (Yan et al, 2009).…”

Section: Frizzleds As Gpcrsmentioning

confidence: 99%

WNT/Frizzled signalling: receptor–ligand selectivity with focus on FZD‐G protein signalling and its physiological relevance: IUPHAR Review 3

Dijksterhuis

Petersen

Schulte

2014

British J Pharmacology

171

144

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The wingless/int1 (WNT)/Frizzled (FZD) signalling pathway controls numerous cellular processes such as proliferation, differentiation, cell‐fate decisions, migration and plays a crucial role during embryonic development. Nineteen mammalian WNTs can bind to 10 FZDs thereby activating different downstream pathways such as WNT/β‐catenin, WNT/planar cell polarity and WNT/Ca2+. However, the mechanisms of signalling specification and the involvement of heterotrimeric G proteins are still unclear. Disturbances in the pathways can lead to various diseases ranging from cancer, inflammatory diseases to metabolic and neurological disorders. Due to the presence of seven‐transmembrane segments, evidence for coupling between FZDs and G proteins and substantial structural differences in class A, B or C GPCRs, FZDs were grouped separately in the IUPHAR GPCR database as the class FZD within the superfamily of GPCRs. Recently, important progress has been made pointing to a direct activation of G proteins after WNT stimulation. WNT/FZD and G protein coupling remain to be fully explored, although the basic observation supporting the nature of FZDs as GPCRs is compelling. Because the involvement of different (i) WNTs; (ii) FZDs; and (iii) intracellular binding partners could selectively affect signalling specification, in this review we present the current understanding of receptor/ligand selectivity of FZDs and WNTs. We pinpoint what is known about signalling specification and the physiological relevance of these interactions with special emphasis on FZD–G protein interactions. Linked Articles This article is part of a themed section on Molecular Pharmacology of GPCRs. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2014.171.issue-5

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“…genesis 48:343-350, 2010. V During development, the Wnt signaling pathways play essential roles in numerous events, including cell proliferation, cell fate specification, regionalization of the forebrain, and axon guidance (Ciani and Salinas, 2005;Garcia-Castro et al, 2002;van de Wetering et al, 2002;Yan et al, 2008). Wnts are secreted glycoproteins with an unusual post-translational modification consisting of a palmitoylation at a conserved cysteine that is crucial for their function (Willert et al, 2003).…”

mentioning

confidence: 99%

A transgenic Cre mouse line for the study of cortical and hippocampal development

Zhou

Zhang

et al. 2010

Genesis

Self Cite

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Wnt signaling regulates cortical and hippocampal development. In a previous study we found that a particular Wnt receptor, Frizzled9 (Fzd9), was selectively expressed in both the developing and adult hippocampus. Taking advantage of the specificity of this promoter, we generated a transgenic cre mouse line using the putative control elements of the Fzd9 gene. In the Fzd9-cre mice, Cre is mainly detected in the developing cortex and hippocampus and is confined to the CA fields and dentate gyrus in adults. Furthermore, by crossing the Fzd9-cre mouse with the ROSA26 reporter line, we examined the activity of Cre and found that it has very high recombination efficiency. Thus, this mouse line will likely prove to be a useful tool for studying cortical and hippocampal development via activation or inactivation of interesting genes.

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Expression of Frizzled10 in mouse central nervous system

Cited by 11 publications

References 15 publications

Frizzled10 mediates WNT1 and WNT3A signaling in the dorsal spinal cord of the developing chick embryo

Frizzled10 mediates WNT1 and WNT3A signaling in the dorsal spinal cord of the developing chick embryo

WNT/Frizzled signalling: receptor–ligand selectivity with focus on FZD‐G protein signalling and its physiological relevance: IUPHAR Review 3

A transgenic Cre mouse line for the study of cortical and hippocampal development

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