Expression of GlyCAM-1, an endothelial ligand for L-selectin, is affected by afferent lymphatic flow.

Mebius, Reina E.; Dowbenko, Donald; Williams, Amy J.; Fennie, Christopher; Lasky, Laurence A.; Watson, SP

doi:10.4049/jimmunol.151.12.6769

Cited by 62 publications

(5 citation statements)

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“…Functional lymphatic vessels are required for the maintenance of the LN microarchitecture, which supports optimal interactions between APCs and rare antigen‐specific lymphocytes64–67 (Figure 3). In the LN, the primary follicles are composed of B cells with follicular DCs located in the cortex of the LN.…”

Section: Lymphatic Function and The Immune Responsementioning

confidence: 84%

“…A fine‐tuned inflammatory response generates an immune reaction to foreign antigens while preventing overt reactions to self‐antigens. The LN structure undergoes dramatic changes following antigen activation, including angiogenesis and lymphangiogenesis, decreased expression of genes contributing to peripheral LN addressin (PNAd), and decreased chemokine production of CCL21 and CXCL13 64,65,82–86. These temporary changes in the LN hinder naïve T cell and DC access and their interactions while enhancing the ability of effector cells to leave the LN and prevent pathological immune‐mediated damage in the LN.…”

Section: Lymphatic Function and The Immune Responsementioning

confidence: 99%

“…The LN structure undergoes dramatic changes following antigen activation, including angiogenesis and lymphangiogenesis, decreased expression of genes contributing to peripheral LN addressin (PNAd), and decreased chemokine production of CCL21 and CXCL13. 64,65,[82][83][84][85][86] These temporary changes in the LN hinder naïve T cell and DC access and their interactions while enhancing the ability of effector cells to leave the LN and prevent pathological immune-mediated damage in the LN. Viral infection and an immune stimulant known as polyinosinic:polycytidylic acid increase FRC suppression of the bystander CD8 T cell responses.…”

Section: Inflammationmentioning

confidence: 99%

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Lymphatic vessels in health and disease

Kesler

Liao

Munn

et al. 2012

WIREs Mechanisms of Disease

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The lymphatic vasculature plays vital roles in tissue fluid balance, immune defense, metabolism and cancer metastasis. In adults, lymphatic vessel formation and remodeling occurs primarily during inflammation, development of the corpus luteum, wound healing, and tumor growth. Unlike the blood circulation, where unidirectional flow is sustained by the pumping actions of the heart, pumping actions intrinsic to the lymphatic vessels themselves are important drivers of lymphatic flow. This review summarizes critical components that control lymphatic physiology.

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Section: Lymphatic Function and The Immune Responsementioning

confidence: 84%

Section: Lymphatic Function and The Immune Responsementioning

confidence: 99%

Section: Inflammationmentioning

confidence: 99%

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Lymphatic vessels in health and disease

Kesler

Liao

Munn

et al. 2012

WIREs Mechanisms of Disease

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show abstract

“…In addition to carrying materials in and out of the LN, lymph flow plays a vital role in maintaining the homeostatic function of HEVs and cell compartmentalization in LNs ( 44 – 46 ). It is important to exclude the possibility that surgical intervention on lymphatic vessels impaired HEV and LN microenvironments, disrupting immune cell homing to the LN.…”

Section: Resultsmentioning

confidence: 99%

“…It has been reported that constant lymph flow is required to maintain HEV-specific gene expression and LN cell homeostasis ( 44 , 46 , 54 , 55 ). HEV-specific gene expression is reduced in the LN during OX skin inflammation ( 45 , 56 – 58 ).…”

Section: Discussionmentioning

confidence: 99%

Lymph-derived chemokines direct early neutrophil infiltration in the lymph nodes uponStaphylococcus aureusskin infection

Xue

Lin

et al. 2022

Proc. Natl. Acad. Sci. U.S.A.

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A large number of neutrophils infiltrate the lymph node (LN) within 4 h after Staphylococcus aureus skin infection (4 h postinfection [hpi]) and prevent systemic S. aureus dissemination. It is not clear how infection in the skin can remotely and effectively recruit neutrophils to the LN. Here, we found that lymphatic vessel occlusion substantially reduced neutrophil recruitment to the LN. Lymphatic vessels effectively transported bacteria and proinflammatory chemokines (i.e., Chemokine [C-X-C motif] motif 1 [CXCL1] and CXCL2) to the LN. However, in the absence of lymph flow, S. aureus alone in the LN was insufficient to recruit neutrophils to the LN at 4 hpi. Instead, lymph flow facilitated the earliest neutrophil recruitment to the LN by delivering chemokines (i.e., CXCL1, CXCL2) from the site of infection. Lymphatic dysfunction is often found during inflammation. During oxazolone (OX)-induced skin inflammation, CXCL1/2 in the LN was reduced after infection. The interrupted LN conduits further disrupted the flow of lymph and impeded its communication with high endothelial venules (HEVs), resulting in impaired neutrophil migration. The impaired neutrophil interaction with bacteria contributed to persistent infection in the LN. Our studies showed that both the flow of lymph from lymphatic vessels to the LN and the distribution of lymph in the LN are critical to ensure optimal neutrophil migration and timely innate immune protection in S. aureus infection.

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Regulation of fucosyltransferase-VII expression in peripheral lymph node high endothelial venules

et al. 1998

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Binding of L-selectin to the highly glycosylated peripheral lymph node addressins (PNAd) plays a central role in the normal recirculation of lymphocytes between the bloodstream and the lymph node. This interaction requires correct fucosylation of the PNAd, mediated by the recently identified fucosyltransferase-VII (Fuc-TVII). Here we show that during ontogeny Fuc-TVII is absent at the day of birth, barely detectable on day 1, and clearly present from day 2 onwards. PNAd expression as detected by the MECA-79 antibody precedes the expression of Fuc-TVII. Furthermore, we demonstrate that in adult mice antigenic stimulation of peripheral lymph nodes leads to a temporary disappearance of Fuc-TVII at days 2 and 3 after stimulation , followed by a complete reappearance by day 4, while expression of MECA-79 is never completely absent during this period. Finally, occlusion of afferent lymphatics to peripheral lymph nodes resulted in a decreased expression of Fuc-TVII in the high endothe-lial venules by day 5, and complete disappearance within 8 days. We conclude that the activity of Fuc-TVII in cells of high endothelial venules is directly affected by afferent lymph and activation processes that occur in the lymph node after antigenic stimulation. The expression of Fuc-TVII is therefore yet another level at which the function of high endothelial venules, and thus lymphocyte trafficking, can be regulated.

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Expression of GlyCAM-1, an endothelial ligand for L-selectin, is affected by afferent lymphatic flow.

Cited by 62 publications

References 0 publications

Lymphatic vessels in health and disease

Lymphatic vessels in health and disease

Lymph-derived chemokines direct early neutrophil infiltration in the lymph nodes uponStaphylococcus aureusskin infection

Regulation of fucosyltransferase-VII expression in peripheral lymph node high endothelial venules

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