Expression of hepatocyte growth factor and c-Met in hypopharyngeal squamous cell carcinoma

Abstract

Positive rates of HGF and c-Met expression in hypopharyngeal SCC were 77.5% and 70%, respectively. HGF staining was significantly correlated with lymph node metastasis and pathologic stage (p < 0.05). c-Met staining was only significantly correlated with lymph node metastasis (p < 0.05). Increased expression of c-Met mRNA (RT-PCR) and protein (Western blotting) was detected in hypopharyngeal cancer tissue.

WITHDRAWN: A meta-analysis of c-Met expression in head and neck cancer

“…After title and abstract checking, 36 studies remained for the further evaluating in details, in which 15 articles were excluded for there were no enough data to calculate the survival rate [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27], one article was removed because of duplication [28]. So, a total of 20 publications were fulfilled the eligibility criteria [5][6][7][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45]. Among them, one study was excluded by the poor data quality [45], so 19 publications were included in the final analysis.…”

Nonclinical Evaluation of the Serum Pharmacodynamic Biomarkers HGF and Shed MET following Dosing with the Anti-MET Monovalent Monoclonal Antibody Onartuzumab

“…Signaling through MET results in cell survival, proliferation, motility, migration, and complex morphogenetic processes (2,7,8). Although MET signaling is essential for embryonic development and tissue repair in adults (2), aberrant signaling through activating MET mutations (3,4,8), MET overexpression (9,10), or dysregulated autocrine expression of HGF and MET in tumor cells (9)(10)(11)(12)(13) contributes to malignant progression and metastasis of cancer cells (2,7,8). High serum HGF levels (14,15), MET overexpression (10), and extensive MET phosphorylation (16) correlate with increasing cancer stage, malignant potential, and poor prognosis.…”

Expression of hepatocyte growth factor and c-Met in non-small-cell lung cancer and association with lymphangiogenesis

“…An increase in the number of lymphatic vessels in the tumor stroma is correlated with lymph node metastasis (3)(4)(5). Several growth factors, including vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), basic fibroblast growth factor (FGF), insulin-like growth factor (IGF) I/II and hepatocyte growth factor (HGF) exhibit lymphangiogenic activity (6)(7)(8)(9)(10)(11)(12)(13). Among these growth factors, HGF and its receptor c-Met are frequently observed to be at high levels in the majority of types of solid tumor, and the overexpression of HGF and/or c-Met have also been correlated with the degree of tumor invasiveness (14)(15)(16)(17).…”