Expression of hTERT in Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma – an Immunohistochemical Analysis

K, Lizbeth Raju; Haragannavar, Vanishri C; Patil, Shankargouda; Rao, Roopa S; Nagaraj, Tejavathi; Augustine, Dominic; Venkatesiah, Sowmya Samudrala; Nambiar, Shwetha

doi:10.1007/s12253-019-00700-6

Cited by 14 publications

(30 citation statements)

References 45 publications

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“…Forty‐four biomarkers were assessed in the malignant transformation of OSF. Only α‐SMA, 23 CD105, 23 hTERT, 25 Ki67, 23,24 and beta‐integrin 26 showed statistically significant alterations in their expression levels. α‐SMA, Ki67, CD105, 23 and hTERT 25 were significantly increased in OSCC‐OSF compared to controls 23 .…”

Section: Resultsmentioning

confidence: 95%

“…Only α‐SMA, 23 CD105, 23 hTERT, 25 Ki67, 23,24 and beta‐integrin 26 showed statistically significant alterations in their expression levels. α‐SMA, Ki67, CD105, 23 and hTERT 25 were significantly increased in OSCC‐OSF compared to controls 23 . Beta‐integrin was decreased in OSCC‐OSF compared with OSF.…”

Section: Resultsmentioning

confidence: 95%

“…α‐SMA, 23 CCL2, CD1a, CD147, caspase‐3, connective tissue growth factor (CTGF), DKK3, 40 hTERT, 25 LC3, MMP‐2, TIMP‐2, TGF‐β1 increased with progressing stages (early to advanced) of OSF. VEGF, tenascin, and WIF1 decreased with OSF progression.…”

Section: Discussionmentioning

confidence: 99%

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Immunohistochemical biomarkers in oral submucous fibrosis: A scoping review

Kavitha

Ranganathan

Sivasamy

et al. 2022

J Oral Pathology Medicine

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Oral submucous fibrosis (OSF) is a chronic progressive, potentially malignant disorder involving the oral mucosa and occasionally the pharynx and upper third of the esophagus. It is characterized by juxta-epithelial hyalinization, fibrosis, epithelial atrophy, and stiffness of the oral mucosa causing limitation in mouth opening and difficulty in eating. 1,2 OSF is caused by chewing areca nut, which is the fourth most addictive substance (following alcohol, tobacco, and caffeine), with 600 million people, globally, consuming it. 3,4 It has a malignant transformation rate of 7%-13%. 5 Biomarkers reflecting the molecular changes in OSF have been studied, with the intent of understanding pathogenesis and identifying biomarkers of clinical relevance. Several molecular biomarkers of

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Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 95%

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Immunohistochemical biomarkers in oral submucous fibrosis: A scoping review

Kavitha

Ranganathan

Sivasamy

et al. 2022

J Oral Pathology Medicine

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“…After removal of duplicates, 2261 records were screened according to titles and abstracts, leaving a sample of 41 papers for full-text evaluation (the studies excluded and their exclusion criteria are listed in the Supplementary Materials ). Finally, 21 studies meeting all eligibility criteria were included for qualitative evaluation and meta-analysis [ 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ].…”

Section: Resultsmentioning

confidence: 99%

Prognostic and Clinicopathological Significance of Telomerase Reverse Transcriptase Upregulation in Oral Cancer: A Systematic Review and Meta-Analysis

González‐Moles

Moya-González

García-Ferrera

et al. 2022

Cancers

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The aim of this systematic review and meta-analysis was to evaluate the current evidence on the prognostic and clinicopathological significance value of telomerase reverse transcriptase (TERT) upregulation in patients with oral squamous cell carcinoma (OSCC). PubMed, Embase, Web of Science, and Scopus were searched for studies published before April 2022, not restricted by date or publication language. The methodological quality of primary-level studies was critically assessed using the Quality in Prognosis Studies (QUIPS) tool. We carried out meta-analyses, explored heterogeneity and its sources, and performed subgroup, meta-regression, sensitivity, and small-study effects analyses. Twenty-one studies (1698 patients) met inclusion criteria. TERT protein overexpression was significantly associated with worse overall survival (hazard ratio [HR] = 3.01, 95% CI = 1.70–5.35, p < 0.001), disease-free survival (HR = 4.03, 95% CI = 1.80–9.05, p = 0.001), and higher histological grade OSCC (odds ratio [OR] = 3.20, 95% CI = 1.83–5.62, p < 0.001). These large effect sizes were consistently obtained by homogeneous subgroups (p > 0.10, I2 = 0.0, respectively), which reflects a high quality of evidence. On the other hand, TERT gene mutations obtained constantly nonsignificant null effect sizes for all outcomes investigated, evidencing no prognostic or clinicopathological value. In conclusion, our findings indicate that TERT upregulation is a prognostic indicator of poor survival in oral cancer. Our findings support the immunohistochemical assessment of TERT overexpression, which could probably be incorporated into the prognostic evaluation of OSCC.

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“…This is achieved through the mediation of a DNA polymerase enzyme, telomerase, which binds hexanucleotide fragments to telomeres. It is now known that telomerase is expressed in most tumor cells, including oral cancer [ 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 , 156 , 157 , 158 , 159 , 160 , 161 , 162 , 163 , 164 , 165 ], conferring resistance to apoptosis and survival. Some evidence in breast cancer has reported that tumor cells may be able to late-activate telomerase for their own benefit.…”

Section: Discussionmentioning

confidence: 99%

Hallmarks of Cancer Expression in Oral Lichen Planus: A Scoping Review of Systematic Reviews and Meta-Analyses

González‐Moles

Pino

Ramos‐García

2022

IJMS

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Oral lichen planus (OLP) is a common chronic inflammatory disease of unknown etiology and likely autoimmune nature that is currently considered an oral potentially malignant disorder, implying that patients suffering from this process are at risk of developing oral cancer in their lifetime. The molecular alterations that develop in OLP and that make the affected oral epithelium predisposed to malignancy are unknown, although, as in other autoimmune diseases (ulcerative colitis, primary biliary cirrhosis, etc.), they may be linked to oncogenesis-promoting effects mediated by the inflammatory infiltrate. So far there is no in-depth knowledge on how these hallmarks of cancer are established in the cells of the oral epithelium affected by OLP. In this scoping review of systematic reviews and meta-analyses the state of evidence based knowledge in this field is presented, to point out gaps of evidence and to indicate future lines of research. MEDLINE, Embase, Cochrane Library and Dare were searched for secondary-level studies published before October 2022. The results identified 20 systematic reviews and meta-analyses critically appraising the hallmarks tumor-promoting inflammation (n = 17, 85%), sustaining proliferative signaling (n = 2, 10%), and evading growth suppressors (n = 1, 5%). No evidence was found for the other hallmarks of cancer in OLP. In conclusion, OLP malignization hypothetically derives from the aggressions of the inflammatory infiltrate and a particular type of epithelial response based on increased epithelial proliferation, evasion of growth-suppressive signals and lack of apoptosis. Future evidence-based research is required to support this hypothesis.

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Expression of hTERT in Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma – an Immunohistochemical Analysis

Cited by 14 publications

References 45 publications

Immunohistochemical biomarkers in oral submucous fibrosis: A scoping review

Immunohistochemical biomarkers in oral submucous fibrosis: A scoping review

Prognostic and Clinicopathological Significance of Telomerase Reverse Transcriptase Upregulation in Oral Cancer: A Systematic Review and Meta-Analysis

Hallmarks of Cancer Expression in Oral Lichen Planus: A Scoping Review of Systematic Reviews and Meta-Analyses

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