Expression of Immune‐Inflammatory Markers in Sites of Chronic Periodontitis in Patients With Type 2 Diabetes

Duarte, Poliana Mendes; Miranda, Tamires Szeremeske; Lima, Jadson Almeida; Gonçalves, Tiago Eduardo Dias; Santos, Vanessa Renata; Bastos, Marta Ferreira; Ribeiro, Fernanda Vieira

doi:10.1902/jop.2011.110324

Cited by 59 publications

(79 citation statements)

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“…* Statistically significant differences between well-controlled and poorly controlled diabetic subjects (Student t-test; p < 0.05). findings of Santos et al 11 and Ribeiro et al 20 , which may indicate a possible role of Th17 pattern in periodontitis when correlated to DM 8 . This cytokine is associated with bone loss and with the production of other inflammatory markers such IL-6, increasing the severity of periodontal inflammation.…”

Section: Discussionmentioning

confidence: 80%

“…In general, poorly controlled diabetes mellitus was associated to the production of cytokines, including IL-17, in sites with chronic periodontal disease. Poor glycemic control has been associated to the severity of periodontal diseases [7][8][9] , so it is critical to understand the immune and inflammatory mechanisms that determine the increased susceptibility to periodontitis in patients with diabetes in comparison with individuals without diabetes 20 . Some studies suggest that the relationship between pro-and anti-inflammatory mediators in the periodontal tissues of diabetic patients would be more prone to inflammation, which would lead to further destruction of the periodontal tissues 11,20 .…”

Section: Discussionmentioning

confidence: 99%

“…In diabetic patients, glycemic control was determined by glycosylated haemoglobin levels (HbA1c), measured by high-performance liquid chromatography, were expressed as a percentage. Subjects who had HbA1c values >8% were assigned to the poorly controlled group, whereas subjects who presented HbA1c levels ≤ 8% were assigned to the well-controlled group 8,11 . The study included 40 subjects divided in the following groups:…”

Section: Methodsmentioning

confidence: 99%

“…The relationship between the mechanism of DM and chronic periodontitis has been described as bidirectional 3 , in which DM negatively affects the periodontal condition and periodontal disease negatively influencing glycemic control, increasing the risk of complications in diabetic patients 7 . Other studies have analyzed glycemic control and periodontal disease [8][9][10][11] and they have found a positive relationship between poorly controlled type 2 DM and the severity of periodontal disease 9,12 . However, the mechanisms that may lead to more severe periodontitis in individuals with poorly controlled diabetes in comparison with well-controlled diabetes remain unclear 7 .…”

Section: Introductionmentioning

confidence: 99%

“…Duarte et al 8 observed higher frequency of IL-4 in diabetic patients with chronic periodontitis, irrespective if it was well controlled or poorly controlled, when compared with healthy patients. IL-4 and IL-10 are involved with the Th2 anti-inflammatory immune response, which leads to a B-lymphocyte-dependent humoral response 22 and is related with a decrease in the activities of cytokines produced by cells of the Th1-pattern [22][23] .…”

mentioning

confidence: 97%

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Glycemic control and the production of cytokines in diabetic patients with chronic periodontal disease

Franco

Moraes

Duarte

et al. 2017

RGO, Rev. Gaúch. Odontol.

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ObjectiveTo evaluate the association of glycemic control and cytokine production in type 2 diabetic subjects with chronic periodontitis Methods Gingival biopsies were performed in 40 patients, divided into four groups: systemically healthy subjects without periodontal disease (S); systemically healthy patients with chronic periodontitis (P); patients with well-controlled type 2 diabetes mellitus (DM) with chronic periodontitis (C); poorly controlled type 2 diabetes mellitus with chronic periodontitis (D). The production of interleukin (IL) -4, -6, -10, -17 and interferon (IFN) -γ was quantified by ELISA. Results The production of IL-4, IL-10, IL-17 and INF-γ was higher on group D when compared to other groups (p <0.05), which in turn were similar (p ≥0.05). In addition, there was no difference in the production of IL-6 in any of the evaluated groups (p≥0.05). ConclusionWere observed significantly elevated levels of pro-inflammatory and anti-inflammatory cytokines in patients with poorly controlled type 2 diabetes and chronic periodontitis, demonstrating that glycemic control may be associated to the immune inflammatory response of sites with chronic periodontitis.

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 97%

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Glycemic control and the production of cytokines in diabetic patients with chronic periodontal disease

Franco

Moraes

Duarte

et al. 2017

RGO, Rev. Gaúch. Odontol.

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The interaction among obesity, Type 2 diabetes mellitus, and periodontitis in Vietnamese patients

Pham

Tran

2018

Clinical & Exp Dental Res

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To examine the relationship between obesity, Type 2 diabetes, and periodontal disease in Vietnamese patients. The sample included 712 patients aged 18 years or older who first visited the Institute of Traditional Medicine, Ho Chi Minh City. All participants completed a questionnaire and underwent anthropometric index measurements for obesity (height, weight, waist, and hip circumferences) and had their body fat percentage measured. A full periodontal examination was performed and a fasting glycemic level was determined. Occurrence and risk of periodontal outcomes were compared across 3 different measurements of obesity (body mass index, waist–hip ratio, and body fat percentage). The prevalence of periodontitis in obese group (37.0%, 36.4%, and 24.6% by body mass index, waist–hip ratio, and body fat percentage, respectively) or Type 2 diabetic group (50.7%) was significantly higher than those without these conditions (p < .05). Subjects with obesity or Type 2 diabetes had significantly greater pocket depth and clinical attachment loss than those who are not obese or diabetic (p < .001). Multivariate logistic regression, adjusted for confounding variables, showed that the likelihood (odds ratio, OR) for periodontitis was highest in the obese and Type 2 diabetic group (OR = 4.24, CI [2.29, 7.86]; OR = 4.06, CI [2.24, 7.36]; and OR = 5.44, CI [2.94, 10.03]), followed by the obese and non‐Type 2 diabetic group (OR = 2.28, CI [1.05, 4.95]; OR = 2.02, CI [1.34, 3.56]), and then the nonobese and Type 2 diabetic group (OR = 2.20, CI [1.21, 3.98]; OR = 1.99, CI [0.93, 4.24] and OR = 5.22, CI [2.76, 9.84]) when obesity was defined by body mass index, waist–hip ratio, and body fat percentage, respectively, (p < .05). There was a significant association between obesity, Type 2 diabetes, or those with both systemic conditions and periodontitis in Vietnamese patients.

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Mimicking and in vitro validating chronic inflammation in human gingival fibroblasts

Agger,

Samara,

Geng

et al. 2025

Archives of Oral Biology

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Expression of Immune‐Inflammatory Markers in Sites of Chronic Periodontitis in Patients With Type 2 Diabetes

Abstract: CP, but not type 2 diabetes mellitus, significantly affected the expressions of the evaluated genes related to the innate and adaptive immune responses.

Cited by 59 publications

References 47 publications

Glycemic control and the production of cytokines in diabetic patients with chronic periodontal disease

Glycemic control and the production of cytokines in diabetic patients with chronic periodontal disease

The interaction among obesity, Type 2 diabetes mellitus, and periodontitis in Vietnamese patients

Mimicking and in vitro validating chronic inflammation in human gingival fibroblasts

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