Expression of Macrophage Colony-Stimulating Factor, Scavenger Receptors, and Macrophage Proliferation in the Pregnant Mouse Uterus.

Kyaw, Yadanar; Hasegawa, Go; Takatsuka, Hisakazu; Shimada-Hiratsuka, Motoko; Umezu, Hajime; Arakawa, Masaaki; Naito, Makoto

doi:10.1679/aohc.61.383

Cited by 22 publications

(22 citation statements)

References 51 publications

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“…Actually, uNK cells at day 15 had very poor organelles. In granules, uNK cells have lysosome activities such as β-glucuronidase, acid phosphatase, aryl sulphatase, aminopeptidase and serine esterase [15]. In these periods, lysosome activity would be elevated for autophagy against degenerative organelles and granules.…”

Section: Discussionmentioning

confidence: 99%

“…Apoptotic uNK cells would adhere to neighboring uNK cells and be incorporated for phagocytotic digestion. This phagocytosis may also be due to macrophage, expressing scavenger receptor in mice uterus [15]. Fukasawa et al proposed that in the rat uNK cell, protein synthesis for apoptosis differs according to the stage of pregnancy and at least two different subtypes exist [5].…”

Section: Discussionmentioning

confidence: 99%

“…Peel reported that degenerative changes are observed in uNK cells at day 17 to parturition and that they include pycnotic nucleus like in an apoptotic change [15]. Our previous study using MRL-lpr/lpr mice, genetically lacking Fas, established that necrotic cell death occurred in uNK cells at late pregnancy [4].…”

mentioning

confidence: 93%

“…Cell number of uNK cells in the MG is most frequent in mid-pregnancy. During late pregnancy to parturition, uNK cells decrease dramatically in number and disappear from the MG [15].…”

mentioning

confidence: 99%

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Cell Death of Uterine Natural Killer Cells in Murine Placenta during Placentation and Preterm Periods.

Kusakabe

Okada

Sasaki

et al. 1999

The Journal of Veterinary Medical Science

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ABSTRACT. In the murine uterus granulated metrial gland (GMG) cells appear only during normal pregnancy. GMG cells belong to a member of natural killer (NK) cells and play an important role in fetus survival and placental growth. Our previous study revealed that mouse GMG/uterine NK (uNK) cells in the late pregnancy rapidly disappear from the uterus, due to the degenerative change classified as necrosis. But there are few reports regarding appearance and morphology of uNK cells during late pregnancy. We examined histologically and histochemically how and when uNK cells undergo cell death. The uNK cells in the metrial gland increased in number and reached maximum until day 12 of pregnancy. Sudden disappearance, however, occurred after day 15 and the granules reduced in both number and size. In situ DNA fragmentation detection revealed that DNA fragmented uNK cells increased in number during days 13 to 15 and reached 70.2% at day 15 of pregnancy. From days 13 to 17, uNK cells were positive against anti-perforin antibody. Ultrastructurally, uNK cells at day 15 showed poor organelles and unusual granules in structure. In uNK cells at day 17, condensation of nucleus chromatin, reduction in size and phagocytosis into other uNK cells were observed. These results suggested that uNK cells undergo at least two types of cell death, classified as necrosis and apoptosis, at the different stages of pregnancy, and that perforin is not a mediator for cell death.-

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 93%

“…Cell number of uNK cells in the MG is most frequent in mid-pregnancy. During late pregnancy to parturition, uNK cells decrease dramatically in number and disappear from the MG [15].…”

mentioning

confidence: 99%

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Cell Death of Uterine Natural Killer Cells in Murine Placenta during Placentation and Preterm Periods.

Kusakabe

Okada

Sasaki

et al. 1999

The Journal of Veterinary Medical Science

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“…Chemokine signaling directs cell movement toward tissues, while egress of circulating cells from vessels requires lymphocyte/endothelial cell interactions. Receptors for CC chemokines are found on NK cells (CCR2 for monocyte chemoattractant protein-1, CCR5 for macrophage-inflammatory protein-1␣ and RANTES) (28,29), and these chemokines are up-regulated in pregnant uteri (30,31). L-selectin and ␣ 4 integrin are critical molecules involved in slowing circulating leukocytes and facilitating rolling, tethering, and docking for vessel egress in secondary lymphoid tissues and at extralymphoid sites of inflammation (32).…”

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confidence: 99%

Contributions from Self-Renewal and Trafficking to the Uterine NK Cell Population of Early Pregnancy

Chantakru¹,

Miller

Roach³

et al. 2002

The Journal of Immunology

157

137

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Uterine NK (uNK) cells are abundant in human and murine uteri during decidualization. It is unclear whether precursors of uNK (pre-uNK) cells self-renew or are recruited from other sites. To assess self-renewal of pre-uNK cells, uterine segments from NK cell-competent mice were grafted orthotopically into NK/uNK cell-deficient or wild-type mice. Only in wild-type recipients did decidualized grafts contain uNK cells, indicating that pre-uNK cells do not self-renew in uterus. To identify pre-uNK cell sources, thymus, bone marrow, lymph node, or spleen cells were grafted from virgin or pregnant NK cell-competent donors into mated NK/uNK cell-deficient recipients. Cells from secondary lymphoid tissues of pregnant donors gave high level uNK cell reconstitution, which was independent of chemokine receptors CCR2 or CCR5. Pregnancy-induced changes to lymphocyte-endothelial cell interactions were documented using adhesion of human lymphocytes to frozen mouse tissue sections under shear. A dynamic increase was observed in L-selectin- and α4 integrin-dependent adhesion of CD56bright NK cells to decidualizing uterus and in human PBL adhesion to lymph node endothelium. These data support a model that attributes the dramatic increases in human and murine uNK cells during decidualization to precursor cell recruitment.

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The apparition macrophage and Döderlein bacillus is negatively correlated in class I Papanicolaou smear: A morphological examination

Ikegami

Watanabe

Kumagai

et al. 2020

Diagnostic Cytopathology

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Background: Nonspecific vaginitis, also known as Bacterial vaginosis, unlike genital candidiasis and trichomoniasis, is caused by microbiome breakdown. Döderlein's bacillus are gram-positive bacillus that form a microbiome, reproduce in the female vagina after gaining sexual maturity, secrete lactic acid, and prevent the growth of other vaginitis-causing bacteria. Clue cell are squamous epithelial cells with Gardnerella sp. attached to their cell surface. The presence of clue cell is one of the diagnostic criteria for nonspecific vaginitis. Additionally, although macrophages are reported to protect against candidal vaginitis, there are no reports of studies examining the association between macrophages and clue cell. Materials and Methods: After re-staining 300 class I specimens by cervical cancer screening with Papanicolaou staining, the appearance of Döderlein's bacillus, macrophages, and clue cell was observed. Result: Age group and appearance of Döderlein's bacillus were negatively correlated. The rate of appearance of macrophages was positively correlated with the age group. In people aged 50 years or more, the appearance rate of clue cells was significantly lower in the macrophage appearance group than that in the non-appearance group. Conclusion: This study suggested that macrophages, and not Döderlein's bacillus, may play an important role in defense against nonspecific vaginitis.

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Expression of Macrophage Colony-Stimulating Factor, Scavenger Receptors, and Macrophage Proliferation in the Pregnant Mouse Uterus.

Cited by 22 publications

References 51 publications

Cell Death of Uterine Natural Killer Cells in Murine Placenta during Placentation and Preterm Periods.

Cell Death of Uterine Natural Killer Cells in Murine Placenta during Placentation and Preterm Periods.

Contributions from Self-Renewal and Trafficking to the Uterine NK Cell Population of Early Pregnancy

The apparition macrophage and Döderlein bacillus is negatively correlated in class I Papanicolaou smear: A morphological examination

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