Expression of Myc target gene mina53 in subtypes of human lymphoma

Abstract

Mina53 (mina) was identified as a gene, which is directly induced by the oncogene c-myc. Elevated expression of Mina53 protein was found in >80% of colon cancer and esophageal squamous cell carcinoma (ESCC). Patients with high expression of Mina53 had shorter survival, suggesting the prognostic usefulness of Mina53. We studied Mina53 expression in lymphoma subtypes to examine its diagnostic significance and its possible role in lymphoma-genesis. Surgical cases of 28 lymphoma and 4 non-neoplastic tissues were stained immunochemically using anti-Mina53 monoclonal antibody. Mina53 expression correlated well with c-Myc expression in lymphoma, suggesting that c-Myc is a controlling factor for mina53 expression also in lymphomas. Although the expression of Mina53 as well as c-Myc was less frequent in lymphoma compared with those of colon and ESCC, increased expression of Mina53 was found in Burkitt-like lymphoma (1/1), Hodgkin's lymphoma (3/5), diffuse large B cell lymphoma (DLBCL) (5/13), lymphomas with a transition from follicular to DLBCL (1/2), with none in follicular (0/4) and T cell lymphoma (0/3). Analyses of the data suggested that Mina53 was frequently expressed in aggressive types of B cell lymphoma. To get more information about the expression of Mina53 in DLBCL, which most frequently occurs among lymphomas, we analyzed the expression of Mina53 in another 21 DLBCL specimens, which were in more advanced stages than those described above. The expression level of Mina53 correlated to the international prognostic index (IPI) values with statistical significance (r=0.477, P=0.0275). Notably, in this group, Mina53 expression did not correlate with c-Myc expression, suggesting that other factor(s) besides c-Myc largely affect the expression of Mina53 in advanced DLBCL. These results suggest that although Mina53 expression is not prominent in lymphoma in general, it may be related to tumor progression of B cell lymphoma.

Expression of Mina53, a novel c-Myc target gene, is a favorable prognostic marker in early stage lung cancer

“…Mina53 is detected by immunohistochemistry using anti-Mina53 monoclonal antibody [5][6][7][8][9][10]. To assess the involvement of Mina53 in lung cancer, we examined its expression in lung cancer tissues.…”

Carcinogenic metalloid arsenic induces expression of mdig oncogene through JNK and STAT3 activation

“…Mdig was first identified as a mineral dust-induced gene from patients with occupational lung diseases and further studies suggested its association with a number of human cancers, including lung cancer [12], colon cancer [23], esophageal cell carcinoma [24], renal cell carcinoma [25], hepatocellular carcinoma [26], breast cancer [27], and lymphoma [28]. Other studies also indicated that oncogene c-Myc plays an important role in regulating the expression of mdig and named mdig as a myc-induced nuclear antigen 53 (mina53) [13].…”

Ablation of Mina53 in Mice Reduces Allergic Response in the Airways

“…Specific inhibition of mina53 expression in some cultured tumor cells severely suppressed their proliferation Tsuneoka et al, 2004), and the overexpression of mina53 has oncogenic potential (Komiya et al, 2010b). Mina53 was shown to be highly expressed in tumor cells in several neoplastic tissues Tsuneoka et al, 2004;Kuratomi et al, 2006;Ishizaki et al, 2007;Teye et al, 2007;Bauer et al, 2009;Komiya et al, 2010a, b;Ogasawara et al, 2010). These results indicate that Mina53 is associated with tumorigenesis.…”