Expression of Neuropilin-2 in salivary adenoid cystic carcinoma: Its implication in tumor progression and angiogenesis

Cai, Yu; Wang, Rong; Zhao, Yi‐Fang; Jia, Jun; Sun, Zhi‐Jun; Chen, Xinming

doi:10.1016/j.prp.2010.08.001

Cited by 23 publications

(23 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Using the cell line ACC-3, inhibition of Nrp2 function with antibody resulted in decreased cell migration, invasion and angiogenesis promotion without influence on the cell proliferation. It was suggested that Nrp2 expression may be correlated with tumor progression and angiogenesis in ACC [71].…”

Section: Other Factorsmentioning

confidence: 99%

Angiogenesis in salivary gland tumors: from clinical significance to treatment

Theocharis

Gribilas

Giaginis

et al. 2015

Expert Opinion on Therapeutic Targets

View full text Add to dashboard Cite

The available data suggest that microvessel density (MVD) evaluation may be capable of discriminating between benign and malignant SGTs, while the use of CD105 antibody seems to be the most suitable. Substantial evidence also suggests that MVD and VEGF expression could be used as prognostic factors in malignant SGTs. Although several agents have shown antiangiogenic activities in adenoid cystic carcinoma cells and xenograft tumors, limited effectiveness in the existing clinical trials was noted. Further studies are strongly recommended for the validation of already well-known and the identification of novel prognostic and predictive angiogenic markers. There is also a strong demand for relatively larger cohorts, homogenous samples referring to same histological SGT subtypes and including an equivalent number of low- and high-grade SGTs.

show abstract

Section: Other Factorsmentioning

confidence: 99%

Angiogenesis in salivary gland tumors: from clinical significance to treatment

Theocharis

Gribilas

Giaginis

et al. 2015

Expert Opinion on Therapeutic Targets

View full text Add to dashboard Cite

show abstract

“…39–40,43 Patients with distant metastasis have a 5-year survival rate as low as 20%. 38 Overall low survival is primarily due to the persistence of tumor growth, late recurrence after initial treatment, perineural invasion, hematogenous spread and invasion to distant and neighboring tissues. 44–47 …”

Section: Introductionmentioning

confidence: 99%

Salivary gland cancer stem cells

2013

View full text Add to dashboard Cite

Emerging evidence suggests the existence of a tumorigenic population of cancer cells that demonstrate stem cell-like properties such as self-renewal and multipotency. These cells, termed cancer stem cells (CSC), are able to both initiate and maintain tumor formation and progression. Studies have shown that CSC are resistant to traditional chemotherapy treatments preventing complete eradication of the tumor cell population. Following treatment, CSC are able to re-initiate tumor growth leading to patient relapse. Salivary gland cancers are relatively rare but constitute a highly significant public health issue due to the lack of effective treatments. In particular, patients with mucoepidermoid carcinoma or adenoid cystic carcinoma, the two most common salivary malignancies, have low long-term survival rates due to the lack of response to current therapies. Considering the role of CSC in resistance to therapy in other tumor types, it is possible that this unique sub-population of cells is involved in resistance of salivary gland tumors to treatment. Characterization of CSC can lead to better understanding of the pathobiology of salivary gland malignancies as well as to the development of more effective therapies. Here, we make a brief overview of the state-of-the-science in salivary gland cancer, and discuss possible implications of the cancer stem cell hypothesis to the treatment of salivary gland malignancies.

show abstract

“…As an additional example, Nrp2 expression has been reported in gastrointestinal cancer cells but not in the normal surrounding mucosa and Nrp2 knockdown leads to decreased migration and invasion in vitro (116). Nrp2 expression is also observed in salivary adenoid cystic carcinoma and is highly correlated with microvessel density, tumor size, invasion and metastasis (117). A number of factors make Nrp2 a particularly promising target for therapeutic intervention (Figure 4).…”

Section: Nrp In Tumor Metastasismentioning

confidence: 99%

“…Specifically, Nrp2 expression is seen in a significant number of tumors where it contributes to tumor metastasis and progression. Indeed, use of a Nrp2 monoclonal antibody has been reported to decrease tumor metastasis (73, 117). Additionally, Nrp2 knockout does not result in embryonic lethality, indicating that therapeutic inhibition of Nrp2 function may be well tolerated in vivo .…”

Section: Nrp In Tumor Metastasismentioning

confidence: 99%

Control of cellular motility by neuropilin-mediated physical interactions

Parker

Kooi

2014

Biomolecular Concepts

View full text Add to dashboard Cite

The Neuropilin (Nrp) family are multi-functional cell surface receptors with critical roles in a number of different cell and tissue types. A core aspect of Nrp function is in ligand-dependent cellular migration, where it controls the multi-step process of cellular motility through integration of ligand binding and receptor signaling. At a molecular level, Nrp’s role in migration is intimately connected to control of adhesive interactions and cytoskeletal reorganization. Here we review the physiological role of Nrp in cellular adhesion and motility in the cardiovascular and nervous systems. We also discuss the emerging pathological role of Nrp in tumor cell migration and metastasis, providing motivation for continued efforts towards developing Nrp inhibitors.

show abstract

Expression of Neuropilin-2 in salivary adenoid cystic carcinoma: Its implication in tumor progression and angiogenesis

Cited by 23 publications

References 25 publications

Angiogenesis in salivary gland tumors: from clinical significance to treatment

Angiogenesis in salivary gland tumors: from clinical significance to treatment

Salivary gland cancer stem cells

Control of cellular motility by neuropilin-mediated physical interactions

Contact Info

Product

Resources

About