Expression of prolactin receptors in the duodenum, kidneys and skeletal system during physiological and sulpiride-induced hyperprolactinaemia

Radojkovic, Danijela; Pešić, Milica; Radojković, Milan; Dimic, Dragan; Nikolić, M; Stoimenov, Tatjana Jevtović; Radenković, Saša; Golubović, Mlađjan; Petković, Tatjana; Antić, Slobodan

doi:10.1007/s12020-018-1730-1

Cited by 4 publications

(15 citation statements)

References 61 publications

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“…PRLR has been identified in the gastrointestinal tract, kidneys, and skeletal system except for mammary glands, the uterus, and ovaries ( 18 – 21 ). The gastrointestinal tract, kidneys, and skeletal system are involved in calcium metabolism ( 22 ). Therefore, PRL may act as a calcium-regulating hormone and affect BMD ( 22 ).…”

Section: Discussionmentioning

confidence: 99%

“…The gastrointestinal tract, kidneys, and skeletal system are involved in calcium metabolism ( 22 ). Therefore, PRL may act as a calcium-regulating hormone and affect BMD ( 22 ). PRL and PRLR play roles in bone formation and affect BMD.…”

Section: Discussionmentioning

confidence: 99%

“…25(OH)VD levels were slightly higher in the NP than in the HP group in all subjects, women, and men without a statistical difference (46. 22…”

Section: Comparison Of Bone Turnover Markers Between Patients With Or...mentioning

confidence: 99%

“…Knockout of PRLR in mice leads to decreased bone formation and reduced BMD ( 21 ). Therefore, PRL may affect BMD by acting as a calcium-regulating hormone ( 22 ).…”

Section: Introductionmentioning

confidence: 99%

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Prolactin is associated with bone mineral density in subjects with type 2 diabetes mellitus

Chen

et al. 2022

Front. Endocrinol.

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PurposeProlactin (PRL) exerts actions in the bone besides lactation and reproduction. This study aimed to investigate whether PRL is related to bone mineral density (BMD) in type 2 diabetes mellitus (T2DM).MethodsA total of 642 patients with T2DM were divided into two groups with age and body mass index (BMI) matched: mildly increased PRL (HP group, n = 101) or normal PRL (NP group, n = 541). BMD was measured by dual-energy X-ray absorptiometry and compared.Results1) BMD, T score at lumbar spine L1–4, right hip and femur neck, and Z score at the femur neck were significantly higher in the HP than in the NP group (0.96 ± 0.16 vs. 0.92 ± 0.15g/cm2, p = 0.019; 0.88 ± 0.15vs. 0.84 ± 0.14 g/cm2, p = 0.007; 0.75 ± 0.17 vs.0.70 ± 0.13 g/cm2, p = 0.001; -0.90 (-1.85, -0.20) vs. -1.40 (-2.20, -0.40), p = 0.018; -0.80 (-1.50, -0.30) vs. -1.10 (-1.80, -0.53), p = 0.026; -1.30 (-2.00, -0.60) vs. -1.70 (-2.20, -1.00), p = 0.001; -0.20 (-0.70, 0.30) vs. -0.40 (-0.90, 0.10), p = 0.026). In men, T and Z scores at the right hip and femur neck were significantly higher in the HP than in the NP group (-0.70 (-1.32, 0.20) vs. -0.90 (-1.50, -0.40), p = 0.038; -0.20 (-0.80, 0.20) vs. -0.50 (-0.10, 0.10), p = 0.027; -0.30 (-0.60, -0.30) vs. -0.40 (-0.90, 0.20), p = 0.038) but not in women. Bone turnover markers have no significant difference between groups (all p > 0.05). 2) BMD at the right hip and Z score at the right hip and femur neck were significantly positively associated with PRL (r = 0.087, p = 0.029; r = 0.089, p = 0.024; r = 0.087, p = 0.029). In men, BMD at L1–4 and the right hip; T score at L1–4, the right hip, and the femur neck; and Z score at the right hip and the femur neck were significantly positively associated with PRL (r = 0.122, p = 0.007; r = 0.105, p = 0.041; r = 0.123, p = 0.016; r = 0.110, p = 0.032; r = 0.115, p = 0.025; r = 0.121, p = 0.018; r = 0.138, p = 0.007) but not significant in women. 3) In men divided into two groups according to T score (T score at the right hip>-1 or T score at the right hip≤-1) or the median BMD at L1–4, the right hip or the femur neck, PRL was significantly higher in the higher BMD than in the lower BMD group (16.32 ± 6.12 vs. 14.78 ± 5.68 ng/ml, p = 0.012; 16.20 ± 6.21 vs. 14.73 ± 5.40 ng/ml, p = 0.014; 16.10 ± 6.01 vs. 14.80 ± 5.77 ng/ml, p = 0.032; 16.17 ± 6.04 vs. 14.76 ± 5.77 ng/ml, p = 0.02; 16.48 ± 6.05 vs. 14.98 ± 5.81 ng/ml, p = 0.020; 16.10 ± 5.98 vs. 14.80 ± 5.87 ng/ml, p = 0.035).ConclusionIncreased PRL was associated with better BMD in patients with T2DM, especially in men. PRL within the biologically normal range may play a protective role in the BMD of T2DM.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…25(OH)VD levels were slightly higher in the NP than in the HP group in all subjects, women, and men without a statistical difference (46. 22…”

Section: Comparison Of Bone Turnover Markers Between Patients With Or...mentioning

confidence: 99%

“…Knockout of PRLR in mice leads to decreased bone formation and reduced BMD ( 21 ). Therefore, PRL may affect BMD by acting as a calcium-regulating hormone ( 22 ).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prolactin is associated with bone mineral density in subjects with type 2 diabetes mellitus

Chen

et al. 2022

Front. Endocrinol.

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“…Increased Prlr expression in the intestine during PHP, facilitating calcium absorption, and decreased expression in the vertebrae, preventing calcium extraction from the skeletal system, may act protectively against maternal skeletal demineralization. Conversely, contrasting findings in DIHP, such as decreased Prlr expression in the intestine and increased expression in vertebrae, may contribute to the more severe effects on bone health associated with DIHP [ 15 ]. Unlike PHP, which typically has a limited duration, DIHP, as seen with certain antipsychotics, can persist for years.…”

Section: Introductionmentioning

confidence: 99%

Significance of Duodenal Prolactin Receptor Modulation by Calcium and Vitamin D in Sulpiride-Induced Hyperprolactinemia

Radojkovic,

Pesic,

Radojkovic

et al. 2024

Medicina

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Background and Objectives: Hyperprolactinemia, as a potential side-effect of some antipsychotic medications, is associated with decreased bone density and an increased risk of fractures. This study investigates whether calcium and vitamin D supplementation affects prolactin receptor (Prlr) gene expression in the duodenum, vertebrae, and kidneys of female rats with sulpiride-induced hyperprolactinemia. Materials and Methods: Twenty-one-week-old female Wistar rats were assigned to three groups: Group S consisted of ten rats who received sulpiride injections (10 mg/kg) twice daily for 6 weeks; Group D (10 rats) received daily supplementation of 50 mg calcium and 500 IU vitamin D along with sulpiride for the last 3 weeks; and Group C consisting of seven age-matched nulliparous rats serving as a control group. Real-time PCR was used to assess Prlr gene expression in the duodenum, vertebrae, and kidneys. Results: In Group S, Prlr gene expression was notably decreased in the duodenum (p < 0.01) but elevated in the vertebrae and kidneys compared to Group C. Conversely, Group D exhibited significantly increased Prlr expression in the duodenum (p < 0.01) alongside elevated expression in the vertebrae and kidneys. Conclusions: In sulpiride-induced hyperprolactinemia, decreased Prlr gene expression in the duodenum may lead to reduced intestinal calcium absorption. Consequently, prolactin may draw calcium from the skeletal system to maintain calcium balance, facilitated by increased Prlr gene expression in the vertebrae. However, vitamin D supplementation in sulpiride-induced hyperprolactinemia notably enhances Prlr gene expression in the duodenum, potentially ameliorating intestinal calcium absorption and mitigating adverse effects on bone health.

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Current Insights in Prolactin Signaling and Ovulatory Function in Health and Disease

Szukiewicz

2024

Preprint

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Prolactin (PRL) is a pleiotropic hormone released from lactotrophic cells of the anterior pituitary gland that also originates from extrapituitary sources and plays an important role in regulating lactation in mammals, as well as other actions. Acting in an endocrine and paracrine/autocrine manner, PRL regulates the hypothalamic-pituitary-ovarian axis, thus influencing the maturation of ovarian follicles and ovulation. This review provides a detailed discussion of the current knowledge on the role of PRL in the context of ovulation and ovulatory disorders, particularly with regard to hyperprolactinemia, which is one of the most common causes of infertility in women. Much attention has been given to the PRL structure and the PRL receptor (PRLR), as well as the diverse functions of PRLR signaling under normal and pathological conditions. The hormonal regulation of the menstrual cycle in connection with folliculogenesis and ovulation, as well as the current classifications of ovulation disorders, are also described. Finally, the state of knowledge regarding the importance of TIDA (tuberoinfundibular dopamine), KNDγ (kisspeptin/neurokinin B/dynorphin) and GnRH (gonadotropin-releasing hormone) neurons in PRL- and kisspeptin (KP)-dependent regulation of the hypothalamic-pituitary-gonadal (HPG) axis in women is reviewed. Based on this review, a rationale for influencing PRL signaling pathways in therapeutic activities accompanying ovulation disorders is presented.

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Expression of prolactin receptors in the duodenum, kidneys and skeletal system during physiological and sulpiride-induced hyperprolactinaemia

Cited by 4 publications

References 61 publications

Prolactin is associated with bone mineral density in subjects with type 2 diabetes mellitus

Prolactin is associated with bone mineral density in subjects with type 2 diabetes mellitus

Significance of Duodenal Prolactin Receptor Modulation by Calcium and Vitamin D in Sulpiride-Induced Hyperprolactinemia

Current Insights in Prolactin Signaling and Ovulatory Function in Health and Disease

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