Expression of Sfrp5/Wnt5a in human epicardial adipose tissue and their relationship with coronary artery disease

Tong, Shan; Du, Yu; Ji, Qingwei; Dong, Ran; Cao, Jian; Wang, Zhijian; Li, Wei; Zeng, Min; Chen, Hongying; Zhu, Xiaogang; Zhou, Yujie

doi:10.1016/j.lfs.2020.117338

Cited by 26 publications

(20 citation statements)

References 41 publications

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“…Besides, the serum level of SFRP5 is also lower in CAD patients compared to the healthy subjects and negatively associates with the presence of CAD. SFRP5 is secreted by visceral fat and its local concentration in EAT may greatly exceed that in subcutaneous adipose, indicating that low SFRP5 and high Wnt5a levels are associated with the presence of CAD, independent of other conventional risk factors ( 165 ). Adiposity, the level of c-reactive protein, leptin and C-C motif chemokine ligand 2 are higher in Mexican Americans consuming a diet high in sugar sweetened beverages, however, the expression of SFRP5 is lower in participants with diet rich in fruits, vegetables and includes low sugar sweetened beverages intake, this reveals that diet contributes to adiposity and pro-inflammation ( 166 ).…”

Section: The Effect Of Sfrps On Cardiovascular Diseasementioning

confidence: 99%

Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases

et al. 2021

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Abnormal gene expression and secreted protein levels are accompanied by extensive pathological changes. Secreted frizzled related protein (SFRP) family members are antagonistic inhibitors of the Wnt signaling pathway, and they were recently found to be involved in the pathogenesis of a variety of metabolic diseases, which has led to extensive interest in SFRPs. Previous reports highlighted the importance of SFRPs in lipid metabolism, obesity, type 2 diabetes mellitus and cardiovascular diseases. In this review, we provide a detailed introduction of SFRPs, including their structural characteristics, receptors, inhibitors, signaling pathways and metabolic disease impacts. In addition to summarizing the pathologies and potential molecular mechanisms associated with SFRPs, this review further suggests the potential future use of SFRPs as disease biomarkers therapeutic targets.

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Section: The Effect Of Sfrps On Cardiovascular Diseasementioning

confidence: 99%

Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases

et al. 2021

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“…Obese human subjects had significantly lower serum Sfrp5 levels than lean controls, while they had significantly higher serum Wnt5a levels (49). Similarly, this inverse pattern of expression for Sfrp5 and Wnt5a was detected in the serum of patients with coronary artery disease (50) and the plasma of patients with type 2 diabetes mellitus (51). An in vitro study confirmed that Sfrp5 alleviated the endothelial dysfunction damage mediated by Wnt5a (52).…”

Section: Wnt5a Triggers Proinflammatory Signaling Cascades and Increamentioning

confidence: 80%

Role of Wnt5a in periodontal tissue development, maintenance, and periodontitis: Implications for periodontal regeneration (Review)

Wei¹,

Liu²,

Guo³

et al. 2020

Mol Med Rep

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“…CAD patients have higher plasma WNT5A levels and lower SFRP5 levels compared with those without CAD, independent of the conventional risk factors [177]. An experiment using the mRNA levels of SFRP5 and WNT5A from epicardial adipose tissue biopsies of CAD patients reconfirmed the results [188]. Additionally, the WNT5A concentration is independently correlated with the occurrence and advancement of coronary calcification [177].…”

Section: Human Relevancementioning

confidence: 83%

The Role of Anti-Inflammatory Adipokines in Cardiometabolic Disorders: Moving beyond Adiponectin

Jung

2021

IJMS

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The global burden of obesity has multiplied owing to its rapidly growing prevalence and obesity-related morbidity and mortality. In addition to the classic role of depositing extra energy, adipose tissue actively interferes with the metabolic balance by means of secreting bioactive compounds called adipokines. While most adipokines give rise to inflammatory conditions, the others with anti-inflammatory properties have been the novel focus of attention for the amelioration of cardiometabolic complications. This review compiles the current evidence on the roles of anti-inflammatory adipokines, namely, adiponectin, vaspin, the C1q/TNF-related protein (CTRP) family, secreted frizzled-related protein 5 (SFRP5), and omentin-1 on cardiometabolic health. Further investigations on the mechanism of action and prospective human trials may pave the way to their clinical application as innovative biomarkers and therapeutic targets for cardiovascular and metabolic disorders.

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Expression of Sfrp5/Wnt5a in human epicardial adipose tissue and their relationship with coronary artery disease

Cited by 26 publications

References 41 publications

Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases

Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases

Role of Wnt5a in periodontal tissue development, maintenance, and periodontitis: Implications for periodontal regeneration (Review)

The Role of Anti-Inflammatory Adipokines in Cardiometabolic Disorders: Moving beyond Adiponectin

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