Expression of Survivin in Oral Squamous Cell Carcinoma

Jinbu, Yoshinori; Tsukinoki, Keiichi; Miyagi, Norito; Senna, Tomohiro; Obi, Yuri; Matsumoto, Koichí; Noguchi, Tadahide; Kusama, Mikio

doi:10.3353/omp.11.41

Cited by 9 publications

(7 citation statements)

References 8 publications

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“…Increased survivin expression is commonly associated with reduced levels of apoptosis and survival rate, increased proliferative index, recurrence rate, and resistance to chemotherapy and radiotherapy, thereby identifying it as a significant independent prognostic indicator of the poor outcome in patients with most tumor types. The immunopositivity for survivin was completely negative in normal oral epithelium, as observed in other studies by Gayathri et al, 10 Lin et al, 11 Khan et al, 12 Li et al, 13 and Jinbu et al 14 Survivin is generally expressed at high levels in embryonic tissues, but present at lower or non-detectable levels in normal adult tissues due to the presence of differentiated cells. 11 In contrast to our findings, few studies have reported mild nuclear and cytoplasmic expression among sporadic cells of basal and parabasal layers.…”

Section: Discussionsupporting

confidence: 78%

“…20 The present study reported a predominant nuclear positivity for survivin in all grades of OSCC though cytoplasmic and nuclear distribution was observed in few cases. Conversely, studies by Jinbu et al, 14 Lippert et al, 21 Li et al, 22 and Pannone et al 23 have demonstrated greater expression of survivin in both cytoplasmic and nuclear regions of keratinocytes in OSCC. It was suggested that the nuclear pool of survivin is involved in promoting cell proliferation, 23 whereas the cytoplasmic pool participates in controlling cell survival.…”

Section: Discussionmentioning

confidence: 92%

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Prognostic Implication of Survivin Expression in Oral Squamous Cell Carcinoma—An Immunohistochemical Study

Ajithkumar¹,

Murali²,

Vani³

2019

The Journal of Contemporary Dental Practice

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Aim: Immunohistochemical expression of survivin was analyzed among the three histological grades (well differentiated, moderately differentiated, and poorly differentiated) of oral squamous cell carcinoma (OSCC). Materials and methods:The study material consisted of 60 formalin-fixed paraffin-embedded tissue samples: 15 cases each of well, moderate, and poorly differentiated OSCC and normal oral mucosal (NOM) tissues as the control. Survivin expression was evaluated immunohistochemically and statistical analysis of data was performed using Fisher's Chi-square and analysis of variance (ANOVA) tests. Results: Survivin was expressed in all grades of OSCC, but absent in normal oral tissue samples. Poorly differentiated OSCC exhibited 51 to 75% immunopositivity (53.3%) and severe staining intensity (46.7%) for survivin, predominantly in nuclear areas. While moderately differentiated OSCC had 26 to 50% immunopositivity (40%) and moderate staining intensity (80%), 5 to 25% immunopositivity (40%) with moderate staining intensity (86.7%) was observed in well-differentiated OSCC. Overall, there was a statistically significant difference among the three grades of OSCC in relation to survivin immunopositivity and immunoreactivity (p < 0.01). Conclusion:This study supports the use of survivin as a potent diagnostic and prognostic marker for OSCC. Clinical significance: Increased survivin expression and its nuclear localization appeared to correlate with a higher grade of malignancy suggesting unfavorable prognosis.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 92%

Prognostic Implication of Survivin Expression in Oral Squamous Cell Carcinoma—An Immunohistochemical Study

Ajithkumar¹,

Murali²,

Vani³

2019

The Journal of Contemporary Dental Practice

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“…Survivin positivity in OSCC cell lines in hamster oral carcinogenesis model expressed 100% and showed that OSCC patients with high survivin expression in the tumor mass had a shorter survival [26]. Likewise many other studies have reported survivin presence in higher rates [13,22,27,28].…”

Section: Discussionmentioning

confidence: 93%

Immunohistochemical evaluation of survivin in oral lichen planus and oral squamous cell carcinoma - a retrospective study

Lingam

Swetha

Manyam

2021

Medicine and Pharmacy Reports

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Introduction. Oral cancer is a multistep process involving enhanced activation of proto-oncogenes. Survivin (anti-apoptotic protein) is one of such proto-oncogenes that contribute to the carcinogenesis by deregulating cell proliferation. Expression of these proteins in cancerous and pre-cancerous lesions helps a better understanding of the etiology, treatment and prognosis. Aim. To evaluate qualitative and quantitative expression of survivin in healthy mucosa, oral lichen planus (OLP) and oral squamous cell carcinoma (OSCC). Methods. A total of 70 cases of formalin fixed paraffin embedded blocks, of which 20 healthy mucosa, 20 OSCC and 30 OLP were included in the study and stained immunohistochemically using antibodies against survivin monoclonal antibody. 4μm sections were stained immunohistochemically, both nuclear and cytoplasmic staining was considered as positive for survivin. Positive and negative stained cells were counted with the help of Olympus BX51 rarefaction microscope and were analyzed quantitatively using image analysis pro plus software. Representative fields were randomly selected at 40X high power magnification. Values obtained were evaluated and tabulated for statistical analysis. Results. There was a statistically significant relation between the expressions of survivin among healthy mucosa, OLP, OSCC with a p value of 0.001. Conclusion. Presence of survivin expression in healthy mucosa, OLP and OSCC, which is an inhibitor of apoptosis protein, can be identified as a useful diagnostic tool for the identification of precancerous lesions and conditions which are at higher risk for progression into invasive carcinoma.

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“…Low survivin expression correlated statistically significantly with better survival rates but not with age, sex, tumor size, the presence of lymph node, or distant metastases [105]. Survivin was found to be preferentially expressed in nonadvanced, nonmetastatic, and chemotherapy-sensitive OSCC [106]. On the contrary, increased expression of survivin was found in high-grade tumors suggesting its contribution to apoptosis resistance in response to therapy [107].…”

Section: Apoptosis and Oral Squamous Cell Carcinomamentioning

confidence: 99%

Apoptosis and Its Significance in Oral Diseases: An Update

Jain

Kasetty

Sridhara

et al. 2013

Journal of Oral Diseases

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Apoptosis is a well defined mode of cell death which plays an imperative role in the development, regulation, and maintenance of the cell populations in multicellular organisms. Apoptosis is implicated in both health and diseases. Errors in apoptotic mechanisms have been allied to a wide range of pathologies including oral diseases. This review presents an update focused on the role and significance of apoptosis in various oral diseases ranging from reactive to benign and malignant pathologies.

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Expression of Survivin in Oral Squamous Cell Carcinoma

Cited by 9 publications

References 8 publications

Prognostic Implication of Survivin Expression in Oral Squamous Cell Carcinoma—An Immunohistochemical Study

Prognostic Implication of Survivin Expression in Oral Squamous Cell Carcinoma—An Immunohistochemical Study

Immunohistochemical evaluation of survivin in oral lichen planus and oral squamous cell carcinoma - a retrospective study

Apoptosis and Its Significance in Oral Diseases: An Update

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