Expression of the chemokine receptor CCR1 in human renal allografts

Mayer, Verena; Hudkins, Kelly L.; Heller, F; Schmid, Holger; Kretzler, Matthias; Brandt, Ulrike; Anders, Hans‐Joachim; Regele, Heinz; Nelson, Peter J.; Alpers, Charles E.; Schlöndorff, Detlef; Segerer, Stephan

doi:10.1093/ndt/gfm007

Cited by 19 publications

(11 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…BDCA-1 + , BDCA-2 (CD303) + , and DC-LAMP (DC-lysosomal associated membrane protein 3, CD208) + cells have also been identified with in acutely rejecting renal allografts168. CCR1 + DC-SIGN + DC are also evident following transplantation169. A recent publication demonstrated increased CD141 hi CLEC9A + and CD1c + CD1a - DCSIGN - mDC170, as well as pDC in human allograft biopsies with histological evidence of fibrosis.…”

Section: Renal DC and Mac In Human Health And Diseasementioning

confidence: 99%

Dendritic cells and macrophages in the kidney: a spectrum of good and evil

et al. 2014

View full text Add to dashboard Cite

Renal dendritic cells (DC) and macrophages (Mac) represent a constitutive, extensive and contiguous network of innate immune cells that provide sentinel and immune intelligence function. They induce and regulate inflammatory responses to freely-filtered antigenic material and protect the kidney from infection. Tissue–resident or infiltrating DC and Mac are key to the initiation and propagation of renal disease, as well as essential contributors to subsequent tissue regeneration regardless of its etiology and pathogenesis. Their identification, functional and phenotypic distinction, interplay and relationship with effector and regulatory adaptive immune cells is complex and incompletely understood. This review discusses both the common and distinct characteristics of these cells, as well as recent key advances in the field that have identified renal-specific functions of DC and Mac that enable these important, phagocytic, antigen-presenting, cells to mediate or mitigate intrinsic kidney disease. We also identify priority areas for further investigation and prospects for translational and therapeutic application of acquired knowledge.

show abstract

Section: Renal DC and Mac In Human Health And Diseasementioning

confidence: 99%

Dendritic cells and macrophages in the kidney: a spectrum of good and evil

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Recipient-derived B cells and B cell clusters (along with B cell transcripts) have been found in acute and chronically rejecting solid organ allografts where they can contribute to both humoral and cellular allograft rejection ( 53 – 56 ). Chemokines and chemokine receptors are critical in leukocyte recruitment, activation, and differentiation, with CXCL10 ligand and its receptor CXCR3 ( 57 ) as well as CXCL13 and CXCR5 ( 58 ) and chemokine receptor CCR1 ( 59 ) governing the recruitment of B cells. Gene expression profiling of renal allograft biopsies has shown that expression of these chemokines plus their corresponding receptors is strongly correlated with rejection than with stable allograft function ( 60 ).…”

Section: Induction and Formation Of Tlos—the Playersmentioning

confidence: 99%

Spoiling for a Fight: B Lymphocytes As Initiator and Effector Populations within Tertiary Lymphoid Organs in Autoimmunity and Transplantation

2017

View full text Add to dashboard Cite

Tertiary lymphoid organs (TLOs) develop at ectopic sites within chronically inflamed tissues, such as in autoimmunity and rejecting organ allografts. TLOs differ structurally from canonical secondary lymphoid organs (SLOs), in that they lack a mantle zone and are not encapsulated, suggesting that they may provide unique immune function. A notable feature of TLOs is the frequent presence of structures typical of germinal centers (GCs). However, little is known about the role of such GCs, and in particular, it is not clear if the B cell response within is autonomous, or whether it synergizes with concurrent responses in SLOs. This review will discuss ectopic lymphoneogenesis and the role of the B cell in TLO formation and subsequent effector output in the context of autoimmunity and transplantation, with particular focus on the contribution of ectopic GCs to affinity maturation in humoral immune responses and to the potential breakdown of self-tolerance and development of humoral autoimmunity.

show abstract

“…Immunohistochemistry and double-immunofluorescence was performed as previously described. 73,74 Anti-human LTb mAb (Clone B27, Biogen), anti-human LTbR (RPA481Hu, Hölzel Diagnostika, Köln, Germany), anti-human CD20 mAb (clone L26, DakoCytomation, Dako Deutschland, Hamburg, Germany), CD3 (CD3-12, Serotec, Oxford, UK), anti-Aquaporin-1 (Millipore, Temecula, CA), and secondary reagents from Alexa Fluor (Life Technologies, Carlsbad, CA) were used. Archival biopsies were included from patients with pauci-immune cGN (n ¼ 10), IgA nephropathy (n ¼ 8), lupus nephritis (n ¼ 8), and membranous nephropathy (n ¼ 10).…”

Section: Immunohistochemistry On Human Tissuementioning

confidence: 99%

The lymphotoxin β receptor is a potential therapeutic target in renal inflammation

Seleznik

Seeger

Bauer

et al. 2016

Kidney International

View full text Add to dashboard Cite

Accumulation of inflammatory cells in different renal compartments is a hallmark of progressive kidney diseases including glomerulonephritis (GN). Lymphotoxin β receptor (LTβR) signaling is crucial for the formation of lymphoid tissue, and inhibition of LTβR signaling has ameliorated several non-renal inflammatory models. Therefore, we tested whether LTβR signaling could also have a role in renal injury. Renal biopsies from patients with GN were found to express both LTα and LTβ ligands, as well as LTβR. The LTβR protein and mRNA were localized to tubular epithelial cells, parietal epithelial cells, crescents, and cells of the glomerular tuft, whereas LTβ was found on lymphocytes and tubular epithelial cells. Human tubular epithelial cells, mesangial cells, and mouse parietal epithelial cells expressed both LTα and LTβ mRNA upon stimulation with TNF in vitro. Several chemokine mRNAs and proteins were expressed in response to LTβR signaling. Importantly, in a murine lupus model, LTβR blockade improved renal function without the reduction of serum autoantibody titers or glomerular immune complex deposition. Thus, a preclinical mouse model and human studies strongly suggest that LTβR signaling is involved in renal injury and may be a suitable therapeutic target in renal diseases.

show abstract

Expression of the chemokine receptor CCR1 in human renal allografts

Cited by 19 publications

References 48 publications

Dendritic cells and macrophages in the kidney: a spectrum of good and evil

Dendritic cells and macrophages in the kidney: a spectrum of good and evil

Spoiling for a Fight: B Lymphocytes As Initiator and Effector Populations within Tertiary Lymphoid Organs in Autoimmunity and Transplantation

The lymphotoxin β receptor is a potential therapeutic target in renal inflammation

Contact Info

Product

Resources

About