Expression of the Dominant-Negative Regulator Id4 Is Induced during Adipocyte Differentiation

Chen, Heping; Weng, Yi Chinn; Schatteman, Gina C.; Sanders, Laura; Christy, Robert J.; Christy, Barbara A.

doi:10.1006/bbrc.1999.0386

Cited by 22 publications

(18 citation statements)

References 22 publications

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“…In apparent contrast to this inhibitory role for the Id family of genes, a more limited number of observations have suggested a role for ID family members in supporting lineage-specific differentiation (18,22,34,36,37). Both ID2 and ID4 have been shown to be induced in various cell culture systems during adipocyte differentiation in vitro (18,22).…”

Section: Discussionmentioning

confidence: 99%

“…In addition to its role in adipocyte differentiation, ID2 also is known to contribute to the circadian regulation of lipid metabolism in vivo (21). The expression of another member of this family of proteins, ID4, increases in response to hormone-induced adipocyte differen-tiation, although its role in adipogenesis and adipose tissue formation is unknown (22). We therefore sought to determine whether ID4 contributes to adipogenesis in vitro and in vivo, and if so what effect it might have on adipose tissue formation.…”

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confidence: 99%

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Inhibitor of DNA Binding 4 (ID4) Regulation of Adipocyte Differentiation and Adipose Tissue Formation in Mice

Murad

Place

Ran

et al. 2010

Journal of Biological Chemistry

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Inhibitor of DNA Binding 4 (ID4) Regulation of Adipocyte Differentiation and Adipose Tissue Formation in Mice

Murad

Place

Ran

et al. 2010

Journal of Biological Chemistry

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“…Probably, this can still be considered the rule. However,`exceptions' have now been described for a number of cell types in which high levels of Id proteins were found in di erentiated cells that have exited the cell cycle (Chen et al, 1999;Cooper et al, 1997;Ishiguro et al, 1996;Jen et al, 1997;Neuman et al, 1993). This behavior typically concerns Id2 and Id4 that are expressed by a variety of di erentiating cell types from the neuroectodermal lineage.…”

Section: Id In Development and Cancer Of The Nervous Systemmentioning

confidence: 99%

Id proteins at the cross-road of development and cancer

2001

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“…Similarly, inhibitor of DNA binding-3 (Id3) can heterodimerize with ADD1/SREBP1, avoiding its binding on E-box [69]. However, the expression of Id4 is increased during 3T3-L1 differentiation, suggesting that it plays a role during this process [47]. In the same cell line, Tang et al [230] showed that Sp1, a retinoblastoma control protein, binds the C/EBPα promoter early during the adipose conversion program, prior to the stimulation of differentiation and then to post-confluent mitoses.…”

Section: The Inhibitors Of the Adipogenic Transcription Factorsmentioning

confidence: 99%

The adipose conversion process: regulation by extracellular and intracellular factors

Boone

Mourot

Gregoire³

et al. 2000

Reprod. Nutr. Dev.

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-White adipose tissue regulates lipid metabolism and acts as a secretory organ. Because of its importance for human health and animal production, many studies have attempted to better understand its development at the cellular and molecular levels by culturing preadipose cells in vitro. This synthesis article describes our current knowledge, acquired by this approach, concerning the regulation of the different steps of the adipocyte differentiation program by extracellular (hormones, cytokines, growth factors, retinoids and fatty acids) and intracellular agents (second messengers and transcription factors). The discrepant effects that have been observed for some of these factors are also discussed. This information is very important in the perspective of a better control of fat deposits in human and breeding species.preadipocyte / differentiation / hormonal agent / second messenger / transcription factor Résumé -Le processus d'adipoconversion : sa régulation par des facteurs extracellulaires et intracellulaires. Le tissu adipeux blanc régule le métabolisme lipidique et agit comme un organe de sécrétion. Étant donné son importance pour la santé humaine et la production animale, de nombreuses études ont tenté de mieux comprendre son développement aux niveaux cellulaire et moléculaire en utilisant des cultures de préadipocytes. Cet article de synthèse décrit notre connaissance actuelle, issue de cette approche, concernant la régulation des différentes étapes du programme de la diffé-renciation adipocytaire par des facteurs extracellulaires (hormones, cytokines, facteurs de croissance, rétinoïdes et acides gras) et intracellulaires (seconds messagers et facteurs de transcription). Les effets divergents observés pour certains de ces facteurs sont également discutés. Ces informations sont très importantes dans la perspective d'un meilleur contrôle des dépôts adipeux chez l'humain et les espèces d'élevage.préadipocyte / différenciation / hormone / second messager / facteur de transcription Reprod. Nutr. Dev. 40 (2000) 325-358 325

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Expression of the Dominant-Negative Regulator Id4 Is Induced during Adipocyte Differentiation

Cited by 22 publications

References 22 publications

Inhibitor of DNA Binding 4 (ID4) Regulation of Adipocyte Differentiation and Adipose Tissue Formation in Mice

Inhibitor of DNA Binding 4 (ID4) Regulation of Adipocyte Differentiation and Adipose Tissue Formation in Mice

Id proteins at the cross-road of development and cancer

The adipose conversion process: regulation by extracellular and intracellular factors

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