2007
DOI: 10.1186/1471-2407-7-5
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Expression of the Na+/l-symporter (NIS) is markedly decreased or absent in gastric cancer and intestinal metaplastic mucosa of Barrett esophagus

Abstract: Background: The sodium/iodide symporter (NIS) is a plasma membrane glycoprotein that mediates iodide (I -) transport in the thyroid, lactating breast, salivary glands, and stomach. Whereas NIS expression and regulation have been extensively investigated in healthy and neoplastic thyroid and breast tissues, little is known about NIS expression and function along the healthy and diseased gastrointestinal tract.

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Cited by 45 publications
(46 citation statements)
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“…There is significant enrichment of mRNA coding for gastric intrinsic factor, which binds cobalamin (vitamin B12) and of the sodium iodide symporter (Slc5a5), confirming immunohistochemical detection of the latter in the gastric mucosa (2,13,76). Whether this represents the principal transporter of dietary iodine uptake, given the relative absence of expression in the rest of the gut, is not known but probable.…”
Section: Digestion and Absorptionmentioning
confidence: 96%
“…There is significant enrichment of mRNA coding for gastric intrinsic factor, which binds cobalamin (vitamin B12) and of the sodium iodide symporter (Slc5a5), confirming immunohistochemical detection of the latter in the gastric mucosa (2,13,76). Whether this represents the principal transporter of dietary iodine uptake, given the relative absence of expression in the rest of the gut, is not known but probable.…”
Section: Digestion and Absorptionmentioning
confidence: 96%
“…The Na + /I 2 symporter (NIS) is a plasma membrane glycoprotein that mediates the active transport of I 2 into the thyroid gland and other tissues, such as salivary glands, gastric mucosa, small intestine and lactating breast (Altorjay et al, 2007;Nicola et al, 2009;Nicola et al, 2012;Tazebay et al, 2000;Wapnir et al, 2003). In the thyroid, I…”
Section: Introductionmentioning
confidence: 99%
“…Other anions, such as perrhenate (ReO 4 − ) (5) and the environmental pollutant perchlorate (ClO 4 − ) (6), are also transported by NIS, but, surprisingly, with an electroneutral (1 Na + : 1 anion) stoichiometry. Besides the thyroid, NIS mediates active I − transport in several other tissues, including the lactating breast (7), salivary glands (7,8), stomach (9), and small intestine (10,11). The function of NIS appears to be an evolutionary adaptation to the scant amount of I − in the environment (12,13).…”
mentioning
confidence: 99%