Expression of THSD7A in neoplasm tissues and its relationship with proteinuria

Abstract

Background Thrombospondin type 1 domain containing 7A (THSD7A) was recently identified target autoantigen in membranous nephropathy (MN). However, patients with positive THSD7A expression were prone to have malignancies. THSD7A was found to be expressed in a variety of malignant tumors. In this study, we investigated the histologic expression of THSD7A in colorectal or breast cancers, as well as the relationship between THSD7A expression and proteinuria in the patients with cancers. Method A total of 101 patients were enrolled in the study, 81 of them had colorectal cancer and 20 had breast cancer. THSD7A expression was detected by immunohistochemical staining in tumor tissues. The clinical and laboratory parameters of these patients before their tumor resection were collected. Results Positive expression rates of THSD7A in the two types of tumor tissues were very high, 97.5% in colorectal cancer, and 100% in breast cancer. THSD7A expression was also detected in lymph nodes of two patients with lymph node metastasis. Total 11 patients (10.9%) had proteinuria before surgery. Among the 4 patients who had proteinuria and were followed up, the proteinuria of 3 patients disappeared after surgery. Conclusions The positive rate of THSD7A expression was very high in human colorectal cancer or breast cancer. It might be an important link between malignant tumors and kidney diseases. Electronic supplementary material The online version of this article (10.1186/s12882-019-1489-5) contains supplementary material, which is available to authorized users.

RETRACTED: Role of Serum and Urine Biomarkers (PLA2R and THSD7A) in Diagnosis, Monitoring and Prognostication of Primary Membranous Glomerulonephritis

“…In this study, serum anti-THSD7A Ab was positive in four biopsy-proven primary MGN subjects and two secondary MGN subjects (one of which was associated with malignancy and the other was due to lupus nephritis type V). This result may be possible for the fact that anti-THSD7A Ab was associated with malignancy [17][18][19] and we can't also rule out the presence of malignancy or lupus nephritis coexisting with primary MGN. Therefore, malignancy should be suspected among anti-THSD7A Ab positive subjects.…”

Primary Membranous Glomerulonephritis: The Role of Serum and Urine Biomarkers in Patient Management

“…Thus, this finding denoted that THSD7A is associated with malignancy [52]. In another study involving 81 patients with breast cancer and 20 with colorectal cancer, THS7A expression was detected by immunohistochemical stains in 100% and 97.5% of breast cancer and colorectal cancer, respectively [53].…”

Idiopathic Membranous Nephropathy: Glomerular Pathological Pattern Caused by Extrarenal Immunity Activity

“…In a cohort of breast and colorectal tumor patients, THSD7A is also expressed in breast tumor tissues (20/20, 100% patients positive) and colorectal tumor tissues (79/81, 97.5% patients positive). More importantly, in 3 of the 4 tumor patients with proteinuria who were followed up, proteinuria was in complete remission within 6 months after tumor resection without any other interventions ( 36 ). However, the kidney disease of these 4 patients were undiagnosed, even though THSD7A is currently considered only associated with IMN.…”