Expression signature of lysosomal-associated transmembrane protein 4B in hepatitis C virus-induced hepatocellular carcinoma

Roy, Gaurav; Roy, Prodyot Kumar; Bhattacharjee, Atanu; Shahid, Mudassar; Misbah, Mohammad; Gupta, Subash; Husain, Mohammad

doi:10.1177/1724600818773631

Cited by 3 publications

(3 citation statements)

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“…LAPTM4B (the lysosome-associated protein transmembrane-4b gene) is considered as an oncogene, and its overexpression has been proven to promote the proliferation of various tumor cells, boost invasion and metastasis, resist apoptosis, initiate autophagy, and assist drug resistance. [35][36][37][38] Overexpression of LAPTM4B in breast cancer cells results in resistance to anthracycline, and its knockdown can sensitize the drug response. 39 NGFRAP1 (nerve growth factor receptor-associated protein 1) is an apoptosisrelated gene, and its expression is downregulated in some solid organ malignancies and chronic lymphocytic leukemia.…”

Section: Discussionmentioning

confidence: 99%

A 4-gene leukemic stem cell score can independently predict the prognosis of myelodysplastic syndrome patients

Wang

Lin

Yao³

et al. 2020

Blood Advances

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Myelodysplastic syndrome (MDS) comprised a heterogeneous group of diseases. The prognosis of patients varies even in the same risk groups. Searching for novel prognostic markers is warranted. Leukemic stem cells (LSCs) are responsible for chemoresistance and relapse in leukemia. Recently, expressions of 17 genes related to stemness of LSCs were found to be associated with prognosis in acute myeloid leukemia patients. However, the clinical impact of LSC genes expressions in MDS, a disorder arising from hematopoietic stem cells, remains unclear. We analyzed expression profile of the 17 stemness-related genes in primary MDS patients and identified expression of 4 genes (LAPTM4B, NGFRAP1, EMP1, and CPXM1) were significantly correlated with overall survival (OS). We constructed an LSC4 scoring system based on the weighted sums of the expression of 4 genes and explored its clinical implications in MDS patients. Higher LSC4 scores were associated with higher revised International Prognostic Scoring System (IPSS-R) scores, complex cytogenetics, and mutations in RUNX1, ASXL1, and TP53. High-score patients had significantly shorter OS and leukemia-free survival (LFS), which was also confirmed in 2 independent validation cohorts. Subgroup analysis revealed the prognostic significance of LSC4 scores for OS remained valid across IPSS-R lower- and higher-risk groups. Furthermore, higher LSC4 score was an independent adverse risk factor for OS and LFS in multivariate analysis. In summary, LSC4 score can independently predict prognosis in MDS patients irrespective of IPSS-R risks and may be used to guide the treatment of MDS patients, especially lower-risk group in whom usually only supportive treatment is given.

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Section: Discussionmentioning

confidence: 99%

A 4-gene leukemic stem cell score can independently predict the prognosis of myelodysplastic syndrome patients

Wang

Lin

Yao³

et al. 2020

Blood Advances

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“…LAPTM4B is a newly identified oncogene (NM_018407, Gene ID: 55353) and was first cloned in human hepatocellular carcinoma (HCC) in 2000 12 . It is a recently discovered gene that has been mapped to chromosome 8q22.1; it contains seven exons and six introns, spans ~50 kb, and is an essential factor in maintaining cellular homeostasis 13 . LAPTM4B exists as two alleles: LAPTM4B*1 with one 19 bp segment (GenBank accession no.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have demonstrated that LAPTM4B polymorphisms were associated with susceptibility to multiple types of cancer, including lung, breast, gastric, colon, ovarian and primary liver cancer, which suggested that LAPTM4B*2 may be associated with a significantly increased risk of developing these types of cancer 14 . Studies have illustrated that LAPTM4B promotes tumorigenesis by inhibiting apoptosis, up regulating autophagy and rendering resistance to chemotherapy 13 . Also overexpression of LAPTM4B was significantly correlated with poor prognosis in breast cancer, gallbladder cancer, ovarian cancer, HCC, gastric cancer and cervical cancer etc 12 .…”

Section: Introductionmentioning

confidence: 99%

Study of Association of Lysosomal Associated Protein Trans Membrane 4 Beta (Laptm4b) Gene Polymorphism With Prostate Cancer

Chobok¹,

Mohammed²

2019

Int Res J Pharm

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Background: According to Annual Report Iraqi Cancer Registry, prostate cancer were classified within top ten cancers in Iraqi male and composed 6.5 % of all cancer cases. Worldwide studies have shown relationship between LAPTM4B gene polymorphism and risk of prostate cancer. Aim: To study the association of LAPTM4B gene polymorphism with prostate cancer in Iraqi population. Methods: This case control study consisted of 80 prostate cancer patients and 80 healthy individuals as control group. Genotyping of LAPTM4B gene polymorphism is carried out by PCR. DNA was extracted from whole blood and genotyping was achieved with specific primers to amplify gene fragments followed by electrophoresis on agarose gel. Various statistical analyses were applied to analyze the data. Results: The LAPTM4B gene polymorphism was associated with decreased risk of Pca in codominant (OR= 49 %, CI = 0.24 _0.99, P = 0.049, *1/2 versus *1/1) and dominant (OR = 47 %, CI = 0.24 _0.90, P = 0.024, *1/2+*2/2 versus *1/1) inheritance models. Conclusion: Our findings suggest that The LAPTM4B*2 allele significantly decreased the risk of Pca compared to LAPTM4B*1 and consider as protective factor in Iraqi population.

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Illustration of missing data handling technique generated from hepatitis C induced hepatocellular carcinoma cohort study

Jose

Vishwakarma

Bhattacharjee

2021

Journal of King Saud University - Science

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Expression signature of lysosomal-associated transmembrane protein 4B in hepatitis C virus-induced hepatocellular carcinoma

Abstract: Together, our results illustrate the LAPTM4B gene as a diagnostic biomarker in patients with hepatocellular carcinoma having documented evidence of chronic hepatitis C virus infection.

Cited by 3 publications

References 36 publications

A 4-gene leukemic stem cell score can independently predict the prognosis of myelodysplastic syndrome patients

A 4-gene leukemic stem cell score can independently predict the prognosis of myelodysplastic syndrome patients

Study of Association of Lysosomal Associated Protein Trans Membrane 4 Beta (Laptm4b) Gene Polymorphism With Prostate Cancer

Illustration of missing data handling technique generated from hepatitis C induced hepatocellular carcinoma cohort study

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