External and circadian inputs modulate synaptic protein expression in the visual system of Drosophila melanogaster

Krzeptowski, Wojciech; Górska-Andrzejak, Jolanta; Kijak, Ewelina; Görlich, Andrzej; Guzik, E.; Moore, Gareth; Pyza, Elżbieta

doi:10.3389/fphys.2014.00102

Cited by 14 publications

(8 citation statements)

References 57 publications

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“…It suggests that many cellular processes in neurons and glial cells might be controlled over time by the cyclic activity of the sodium pump. In addition to cellular processes in neurons and glia, synaptic transmission is also controlled by the clock, since expression of brp and level of BRP (Górska-Andrzejak et al, 2013 ) as well as other genes and their proteins in synapses, oscillate during a 24 h period (Krzeptowski et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Clock and clock-controlled genes are differently expressed in the retina, lamina and in selected cells of the visual system of Drosophila melanogaster

Damulewicz

Łoboda

Bukowska-Straková

et al. 2015

Front. Cell. Neurosci.

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The retina and the first optic neuropil (lamina) of Drosophila show circadian rhythms in various processes. To learn about the regulation of circadian rhythms in the retina and lamina and in two cell types, glial and the lamina L2 interneurons, we examined expression of the following clock genes; per, tim, clk, and cry and clock-controlled genes (ccgs); Atpα, nrv2, brp, Pdfr. We found that the expression of gene studied is specific for the retina and lamina. The rhythms of per and tim expression in the retina and glial cells are similar to that observed in the whole head and in clock neurons, while they differ in the lamina and L2 cells. In both the retina and lamina, CRY seems to be a repressor of clk expression. In L2 interneurons per expression is not cyclic indicating the other function of PER in those cells than in the circadian molecular clock. In contrast to per and tim, the pattern of clk and cry expression is similar in both the retina and lamina. The retina holds the autonomous oscillators but the expression of cry and ccgs, Atpα and nrv2, is also regulated by inputs from the pacemaker transmitted by PDF and ITP neuropeptides.

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Section: Discussionmentioning

confidence: 99%

Clock and clock-controlled genes are differently expressed in the retina, lamina and in selected cells of the visual system of Drosophila melanogaster

Damulewicz

Łoboda

Bukowska-Straková

et al. 2015

Front. Cell. Neurosci.

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“…The structural changes are reflected by measurable changes in protein abundance. Already a short light stimulation significantly increases the level of BRP, Synapsin and Dlg proteins in the Drosophila lamina even just for 15 min exposure to light [ 103 ]. In addition to these rapid changes, late-onset modifications alter synaptic composition by prolonged light exposure.…”

Section: Plasticity During Adult Life and Ageingmentioning

confidence: 99%

Structural aspects of plasticity in the nervous system of Drosophila

2018

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Neurons extend and retract dynamically their neurites during development to form complex morphologies and to reach out to their appropriate synaptic partners. Their capacity to undergo structural rearrangements is in part maintained during adult life when it supports the animal’s ability to adapt to a changing environment or to form lasting memories. Nonetheless, the signals triggering structural plasticity and the mechanisms that support it are not yet fully understood at the molecular level. Here, we focus on the nervous system of the fruit fly to ask to which extent activity modulates neuronal morphology and connectivity during development. Further, we summarize the evidence indicating that the adult nervous system of flies retains some capacity for structural plasticity at the synaptic or circuit level. For simplicity, we selected examples mostly derived from studies on the visual system and on the mushroom body, two regions of the fly brain with extensively studied neuroanatomy.

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“…The presynaptic profiles of tetrad synapses exhibit a bimodal rhythm, with two peaks in the morning and in the evening, whereas the feedback synapse frequency peaks at night (Woźnicka et al, 2015 ). Remodeling of these synaptic contacts is correlated with daily or circadian fluctuations in synaptic protein levels, such as Bruchpilot (Górska-Andrzejak et al, 2013 ), Synapsin and Disc large (Krzeptowski et al, 2014 ).…”

Section: Drosophila Melanogaster As a Model Species To Studymentioning

confidence: 99%

Circadian Plasticity in the Brain of Insects and Rodents

Krzeptowski

Hess

Pyza

2018

Front. Neural Circuits

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In both vertebrate and invertebrate brains, neurons, glial cells and synapses are plastic, which means that the physiology and structure of these components are modified in response to internal and external stimuli during development and in mature brains. The term plasticity has been introduced in the last century to describe experience-dependent changes in synapse strength and number. These changes result from local functional and morphological synapse modifications; however, these modifications also occur more commonly in pre- and postsynaptic neurons. As a result, neuron morphology and neuronal networks are constantly modified during the life of animals and humans in response to different stimuli. Nevertheless, it has been discovered in flies and mammals that the number of synapses and size and shape of neurons also oscillate during the day. In most cases, these rhythms are circadian since they are generated by endogenous circadian clocks; however, some rhythmic changes in neuron morphology and synapse number and structure are controlled directly by environmental cues or by both external cues and circadian clocks. When the circadian clock is involved in generating cyclic changes in the nervous system, this type of plasticity is called circadian plasticity. It seems to be important in processing sensory information, in learning and in memory. Disruption of the clock may affect major brain functions.

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External and circadian inputs modulate synaptic protein expression in the visual system of Drosophila melanogaster

Cited by 14 publications

References 57 publications

Clock and clock-controlled genes are differently expressed in the retina, lamina and in selected cells of the visual system of Drosophila melanogaster

Clock and clock-controlled genes are differently expressed in the retina, lamina and in selected cells of the visual system of Drosophila melanogaster

Structural aspects of plasticity in the nervous system of Drosophila

Circadian Plasticity in the Brain of Insects and Rodents

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