External otitis caused by infection with Pseudomonas aeruginosa or Candida albicans cured by use of a topical group III steroid, without any antibiotics

Abstract

It was possible to cause P. aeruginosa and C. albicans infections in an animal model. In the P. aeruginosa-infected animals, only the group III steroid treatment cured all the animals. In the C. albicans-infected animals, group III steroid treatment resolved external otitis faster than the other treatment modalities.

The Role of Topical Thymoquinone in the Treatment of Acute Otitis Externa; an Experimental Study in Rats

“…Similar rates of bacteria eradication were determined in the group administered with saline. In our study, the bacteria eradication rates of the group administered with topical steroid were lower than those reported in the Emgard et al [9] study with the use of budesonide, which may be explained by topical dexamethasone not exhibiting as potent anti-inflammatory property as budesonide and that the content did not have isopropanol with which the environment developed an acidic pH. In the current study, the similar rates of culture positivity obtained in Groups II and VI can be attributed to the steroid showing a similar effect to that of saline.…”

“…This indicates that a 0.4% dose of TQ has a strong anti-inflammatory effect. In a rat model study by Emgard et al [9] , 100% efficacy of budesonide was determined on Days 10 and 20 of treatment with respect to bacteria eradication. Budesonide alone was stated to have cured the experimental AOE more effectively than a weak steroid combined with an antibiotic hydrocortisone acetate combined with oxytetracycline and polymixin B (HCPB), and this was attributed to the fact that inflammation is a major mechanism in the development of AOE, irrespective of the presence of either bacteria or fungi.…”

“…Approximately 1 minute after the trauma, 0.1 mL P. aeruginosa (1.5×10 7 colony-forming units (CFU)/ mL] drops were administered. The standard strain of P. aeruginosa ATCC 27853 was used [9] . The external otitis model was applied to 40 of the 48 rats in the study.…”

“…Sections of 4 µm in thickness were cut, stained with hematoxylin and eosin, and evaluated in a random order by a pathologist blinded to the groups using an Olympus BX53 microscope ((ZA 3262, U-OCMC, 24 mm diameter, 10/100X); the modified Emgard et al [9,10] classification was used. The thicknesses of the stroma, keratin layer, and epithelium in the EAC were measured using an occulometer.…”

Tube associated otorrhea in children with recurrent acute otitis media; results of a prospective randomized study on bacteriology and topical treatment with or without systemic antibiotics

“…This type of topical preparation also seems to have the advantage of not causing any significant bacterial resistance [8]. The action of the hydrocortisone component alone is not sufficiently studied to comment on, but there are evidence collected for other steroids and their effectiveness in treatment of infections of the EAC (external otitis) [9,10]. It also seems to be more effective to use a combination of topical antibiotics and a steroid in treatment of tube otorrhea than to use topical antibiotics alone [11].…”