Extra-virgin olive oil-enriched diet modulates DSS-colitis-associated colon carcinogenesis in mice

Influence of extra virgin olive oil diet enriched with hydroxytyrosol in a chronic DSS colitis model

“…Our results are also coherent with studies from our investigation group that demonstrated that EVOO prevents the development of dysplasia and cancer after chronic inflammation [7]. In addition, although there are few designs of phenolic compounds at intestine level, the anti-inflammatory effects observed may be due to its antioxidant properties, since reactive oxygen species are significantly involved in this pathology.…”

“…Minor components, present in a small amount (about 2% of oil weight), include more than 230 chemical compounds such as aliphatic and triterpenic alcohols, sterols, hydrocarbons, volatile compounds and antioxidants represented by polyphenols [5]. Most of the work has focused on the health benefits of EVOO showing important effects as antioxidant, anti-inflammatory, chemopreventive and anticancer [5][6][7]. Many of these benefits are due, in addition to its high proportion of oleic acid, to the high content of phenolic compounds, which have mainly antioxidant [8], anti-inflammatory and anticancer activities, among others [7,9].…”

“…Most of the work has focused on the health benefits of EVOO showing important effects as antioxidant, anti-inflammatory, chemopreventive and anticancer [5][6][7]. Many of these benefits are due, in addition to its high proportion of oleic acid, to the high content of phenolic compounds, which have mainly antioxidant [8], anti-inflammatory and anticancer activities, among others [7,9]. Among the olive oil phenolic compounds, hydroxytyrosol is considered one of the most abundant and representative olive oil phenols; indeed, studies have demonstrated that it has cardioprotective, antiinflammatory, antiplatelet aggregation effects, antimicrobial and anticancer activities [10].…”

Nicotinic Acetylcholine Receptor Expression and Susceptibility to Cholinergic Immunomodulation in Human Monocytes of Smoking Individuals

“…data). Moreover, an extra-virgin olive oil-enriched diet (10%) showed protective effects in experimental mouse models of dextran sulfate sodium colitis and endotoxic shock [38,39]. In our study, olive oil administration reduced LPS-induced TNF production in whole blood samples of 4 healthy subjects, while it enhanced TNF production in 3 other volunteers.…”

Role of Fatty Acids in the Resolution of Autoimmune and Inflammatory Diseases

“…Another study has described a beneficial effect of extra virgin olive oil in colitis associated colon carcinogenesis. A reduction on colonic inflammation, proinflammatory cytokines and less incident and multiplicity of tumours have been reported in rats fed with extra virgin olive oil versus sunflower oil (Sanchez-Fidalgo et al, 2010). Generally animal models have shown a beneficial effect of n-3 and n-9 fatty acids in the development of IBD.…”