2014
DOI: 10.1186/1756-6606-7-25
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Extracellular signal-regulated kinase (ERK) activation is required for itch sensation in the spinal cord

Abstract: BackgroundItch, chronic itch in particular, can have a significant negative impact on an individual’s quality of life. However, the molecular mechanisms underlying itch processing in the central nervous system remain largely unknown.ResultsWe report here that activation of ERK signaling in the spinal cord is required for itch sensation. ERK activation, as revealed by anti-phosphorylated ERK1/2 immunostaining, is observed in the spinal dorsal horn of mice treated with intradermal injections of histamine and com… Show more

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Cited by 35 publications
(66 citation statements)
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“…This is most likely due to reduced transactivation of the epidermal growth factor receptor by SP/NK1R (data not shown) that has also been reported by others . Our data are in line with previous reports as the importance of ERK1/2 activation in the spinal cord for itch sensations has been already demonstrated . But, to the best of our knowledge we are the first to show that it may be an important factor for itch perception in the skin, too.…”
Section: Discussionsupporting
confidence: 93%
“…This is most likely due to reduced transactivation of the epidermal growth factor receptor by SP/NK1R (data not shown) that has also been reported by others . Our data are in line with previous reports as the importance of ERK1/2 activation in the spinal cord for itch sensations has been already demonstrated . But, to the best of our knowledge we are the first to show that it may be an important factor for itch perception in the skin, too.…”
Section: Discussionsupporting
confidence: 93%
“…We validated the reliability of the microarray results by RT- (22). These data were consistent with our results describing Sgk1was markedly up-regulated in mouse responding to compound 48/80.…”
Section: Discussionsupporting
confidence: 90%
“…DNFB treatment was previously established as a model of contact dermatitis [36] that has been utilized to produce acute itch [30,38] and allergic pruritus [39] in mice. We recorded scratching behavior for 30 min at progressive time points following the cessation of DNFB treatment in mice receiving DNFB painting with and without intrathecal administration of the microglial inhibitor minocycline (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Because pain and itch are closely related somatosensory sensations processed by second-order neurons in the dorsal root ganglion [30], microglial cells may act as neuroimmune regulators of both sensations [20]. In our study, we examined the potential role of microglia as mediators of chronic pruritus in a mouse model using repeated applications of DNFB to produce prolonged scratching for at least 7 d beyond the last pruritogenic application.…”
Section: Discussionmentioning
confidence: 99%
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