Extracorporeal shock waves: From lithotripsy to anti-inflammatory action by NO production

Mariotto, Sofia; Cavalieri, Elisabetta; Amelio, Ernesto; Ciampa, Anna Rosa; Prati, Alessandra Carcereri de; Marlinghaus, Ernst; Russo, Sergio; Suzuki, Hisanori

doi:10.1016/j.niox.2004.12.005

Cited by 215 publications

(181 citation statements)

References 39 publications

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“…Finally we are evaluating whether a modification in skin thickness is detectable by ultrasonography in a longer period of observation. patients is in accordance with literature [6,7,17], but further studies are needed.…”

Section: Discussionsupporting

confidence: 91%

“…During the last 10 years this tecnique was found to induce an immediate anthalgic and anti-inflammatory effect and a long-term tissue regeneration together with increase of angiogenesis [5][6][7][8][9]16]. One of the possible mechanisms of action of the anti-inflammatory effect of ESWT may be related to the ability of ESW to keep local NO contents at a physiological level in the early phase of inflammatory response, enhancing either a non-enzymatic or enzymatic production of NO [15].…”

Section: Discussionmentioning

confidence: 99%

“…One of the possible mechanisms of action of the anti-inflammatory effect of ESWT may be related to the ability of ESW to keep local NO contents at a physiological level in the early phase of inflammatory response, enhancing either a non-enzymatic or enzymatic production of NO [15]. Therefore induction of NO 9 synthesis has been suggested to be one of the most important mechanism implicated in the anti-inflammatory effect of ESWT, while increased expression of VEGF and the consequent mobilization of endothelial progenitor cells can explain the proangiogenic action [6][7][8]17]. It has been recently demonstrated that, in addition to angiogenesis due to migration and proliferation of endothelial cells in situ, EPCs contribute to neovascularization in ischemic tissue through a vasculogenetic mechanism and through secretion of a variety of angiogenic factors [18][19].…”

Section: Discussionmentioning

confidence: 99%

“…First applied in 1980 for the treatment of kidney stones, during the last 10 years this tecnique was found to induce an immediate anthalgic and antiinflammatory effect and a long-term tissue regeneration together with increase of angiogenesis [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

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Effects of shock wave therapy in the skin of patients with progressive systemic sclerosis: a pilot study

et al. 2010

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Results: After ESWT we observed a rapid and persistent reduction of RSS and decrease of VAS. There was no difference in skin thickness before and after ESWT; however we observed a more regular skin structure and an improvement in skin vascularization 90 days after treatment. EPCs and CECs increased 60 and 90 days after treatment, while serological biomarkers showed no variation before and after therapy. Conclusions: ESWT resulted in an improvement of VAS, RSS and of skin vascularscore. An increase of CECs and EPCs was also observed after therapy.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of shock wave therapy in the skin of patients with progressive systemic sclerosis: a pilot study

et al. 2010

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“…Total cellular RNA was purified as described above and reverse transcribed into cDNA, using MMLV reverse transcriptase and oligo dT (12)(13)(14)(15)(16)(17)(18) as primers. cDNA was amplified for the iNOS gene (450 bp) or TNF-a gene (200 bp) using specific primers (iNOS forward: 5 0 -TCCTTGCATCCTCATCGGGCC-3 0 , iNOS reverse: 5 0 -TCGTGA-TAGCGCTTCTGGCTCT-3 0 ; TNFa forward: GAGCTGAGAGA-TAACCAGCTGGTG-3 0 , TNFa reverse 5 0 -CAGATAGATGGGC-TCATACCAGGG-3 0 ).…”

Section: Rt-pcrmentioning

confidence: 99%

Nitric oxide mediates anti‐inflammatory action of extracorporeal shock waves

et al. 2005

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Here, we show that extracorporeal shock waves (ESW), at a low energy density value, quickly increase neuronal nitric oxide synthase (nNOS) activity and basal nitric oxide (NO) production in the rat glioma cell line C6. In addition, the treatment of C6 cells with ESW reverts the decrease of nNOS activity and NO production induced by a mixture of lipopolysaccharides (LPS), interferon-c (IFN-c) plus tumour necrosis factor-a (TNF-a). Finally, ESW treatment efficiently downregulates NF-jB activation and NF-jB-dependent gene expression, including inducible NOS and TNF-a. The present report suggests a possible molecular mechanism of the anti-inflammatory action of ESW treatment.

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The effect of shock wave lithotripsy on nitric oxide and malondialdehyde levels in plasma and urine samples

Aksoy

Turhan

et al. 2006

Cell Biochemistry & Function

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Shock wave lithotripsy (SWL) is accepted as the first treatment choice for most urinary stones, but it has adverse effects on the kidneys. The mechanisms underlying shock wave-induced renal injury have been discussed and include shear stress, thermal and cavitation effects and free radical formation. We investigated the effects of SWL on plasma and urinary nitrite, a stable metabolite of nitric oxide (NO), and malondialdehyde (MDA) concentrations. Between February and October 2004, 12 men and 8 women with renal calculi were treated using a Dornier MPL-9000 lithotriptor. The ages ranged from 22 to 45 years (average age: 33.7 years). Plasma and urinary NO and MDA levels were analysed before, immediately after, 30 and 60 min and 24 h after SWL. Plasma NO levels were higher than baseline levels immediately, and at 30, 60 min and 24 h after treatment (p = 0.016, p = 0.031, p = 0.033 and p = 0.045, respectively). Simultaneously, the mean urinary NO levels also showed significant elevation after SWL compared with baseline values, except for 24 h (p = 0.021, p = 0.023 and p = 0.048, respectively). The mean levels of plasma MDA showed statistically significant elevation immediately, and 30 and 60 min after SWL termination compared with pre-SWL values (p = 0.012, p = 0.008 and p = 0.012, respectively). Urinary MDA levels obtained immediately (p = 0.035), and 30 (p = 0.006) and 60 (p = 0.045) min after SWL were increased compared to pre-SWL values. We speculate that SWL treatment causes oxidative stress caused by renal ischemia-reperfusion (I/R) injury. Additionally, the increase of NO production may have prevented renal damage caused by vasoconstriction.

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Extracorporeal shock waves: From lithotripsy to anti-inflammatory action by NO production

Cited by 215 publications

References 39 publications

Effects of shock wave therapy in the skin of patients with progressive systemic sclerosis: a pilot study

Effects of shock wave therapy in the skin of patients with progressive systemic sclerosis: a pilot study

Nitric oxide mediates anti‐inflammatory action of extracorporeal shock waves

The effect of shock wave lithotripsy on nitric oxide and malondialdehyde levels in plasma and urine samples

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