Extract and compounds obtained from mandevilla velutina inhibit arachidonic acid-induced ear oedema in mice, but not rat stomach contraction

Calixto, João B.; Zanini, JC Júnior; Ab, Cruz; Ra, Yunes; Ys, Medeiros

doi:10.1016/0090-6980(91)90057-m

Cited by 25 publications

(6 citation statements)

References 16 publications

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“…As negative control, the contralateral paw received 20 mL PBS. At several times after injection of serotonin or CFA, edema was measured by use of an analytical balance and expressed in grams as the difference between the test and control paws [11].…”

Section: Serotonin-and Cfa-induced Paw Edema Assaysmentioning

confidence: 99%

Evaluation of the Analgesic and Anti-Inflammatory Effects of a Brazilian Green Propolis

et al. 2006

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Phamacological activities of a standard ethanol extract G1 from Brazilian green propolis, typified as BRP1, was evaluated in mouse models of pain and inflammation. Intraperitoneal injection ( I. P.) of G1 inhibited acetic acid-induced abdominal constrictions with an ID (50) = 0.75 +/- 0.05 mg/kg, and in the formalin test the ID (50) values were 0.85 +/- 0.07 mg/kg and 13.88 +/- 1.12 mg/kg, respectively, for the neurogenic and inflammatory phases. The extract was ineffective when assessed in the hot-plate assay. In serotonin-induced paw edema, G1 led to a maximal inhibition (MI) of 51.6 % after 120 min when administered I. P. and of 36 % after 15 min by the oral route ( O. R.). When the inflammatory agent was complete Freund's adjuvant, inhibition of paw edema was also observed after administration of the extract by both routes. In the capsaicin-induced ear edema the ID (50) values were 1.09 +/- 0.08 mg/kg ( I. P.) and 10.00 +/- 0.90 mg/kg ( O. R.). In the acute carrageenan-induced inflammatory reaction induced by carrageenan, G1 reduced the number of neutrophils in the peritoneal cavity with IC (50) values of 0.72 +/- 0.08 mg/kg and 4.17 +/- 0.50 mg/kg, by I. P. or O. R. administration, with a preferential migration of polymorphonuclear neutrophils. IN VITRO, G1 decreased nitric oxide production in LPS-stimulated RAW 264.7 cells (IC (50) = 41.60 microg/mL), and also the luciferase activity in TNF-alpha-stimulated HEK 293 cells transfected with NF-kappaB-luciferase reporter gene driven by the nuclear factor kappaB (NF-kappaB) (IC (50) = 200 microg/mL). This extract, which at low concentrations induces anti-inflammatory and analgesic effects in mouse models, presents a high content of flavonoids, known to inhibit inducible NOS (iNOS) activity. These data taken together led us to reinforce the hypothesis in the literature that the anti-inflammatory effect of propolis may be a due to inhibition of iNOS gene expression, through interference with NF-kappaB sites in the iNOS promoter.

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Section: Serotonin-and Cfa-induced Paw Edema Assaysmentioning

confidence: 99%

Evaluation of the Analgesic and Anti-Inflammatory Effects of a Brazilian Green Propolis

et al. 2006

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“…The micrometer was applied near the tip of the ear, slightly distal to the cartilaginous ridges, and the thickness was recorded in µm (Calixto et al, 1991).…”

Section: Croton Oil-induced Ear Edemamentioning

confidence: 99%

Topical anti-inflammatory activity of semisolid containing standardized Aleurites moluccana L. Willd (Euphorbiaceae) leaves extract

Hoepers

Souza

Quintão

et al. 2015

Journal of Ethnopharmacology

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This study demonstrated for the first time the mechanisms involved in the topical anti-inflammatory effect presented by the semisolid containing A. moluccana dried extract pointing as the main mechanism is the reduction in the leukocyte migration and consequently resulting in diminished levels of cytokins and chemokines, indicating this herbal product as a promissor anti-inflammatory phytomedicine to treat skin inflammatory diseases.

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“…Ear thickness was measured before and after induction of the inflammatory response, using a micrometer (Mitutoyo Series 293). The micrometer was applied near the tip of the ear, slightly distal to the cartilaginous ridges, and the thickness was recorded in mm (Calixto et al, 1991).…”

Section: Croton Oil-induced Ear Oedemamentioning

confidence: 99%

Antinociceptive, anti-inflammatory and wound healing features in animal models treated with a semisolid herbal medicine based on Aleurites moluccana L. Willd. Euforbiaceae standardized leaf extract

Cesca

Faqueti

Rocha

et al. 2012

Journal of Ethnopharmacology

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Extract and compounds obtained from mandevilla velutina inhibit arachidonic acid-induced ear oedema in mice, but not rat stomach contraction

Cited by 25 publications

References 16 publications

Evaluation of the Analgesic and Anti-Inflammatory Effects of a Brazilian Green Propolis

Evaluation of the Analgesic and Anti-Inflammatory Effects of a Brazilian Green Propolis

Topical anti-inflammatory activity of semisolid containing standardized Aleurites moluccana L. Willd (Euphorbiaceae) leaves extract

Antinociceptive, anti-inflammatory and wound healing features in animal models treated with a semisolid herbal medicine based on Aleurites moluccana L. Willd. Euforbiaceae standardized leaf extract

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