Extract of Rhodiola rosea Radix Reduces the Level of C-Reactive Protein and Creatinine Kinase in the Blood

Абидов, М. Т.; Грачев, С. В.; Сейфулла, Р. Д.; Ziegenfuss, Tim N.

doi:10.1023/b:bebm.0000046940.45382.53

Cited by 39 publications

(40 citation statements)

References 8 publications

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“…Furthermore, rhodiola may act as a stimulant to optimize serotonin and dopamine levels [86]. Acute supplementation (i.e., 2 days) has been shown to increase time to exhaustion and VO 2 peak by acting as an antioxidant and reducing the perception of fatigue [87-90]. Together these ingredients may have positively influenced CV and training volume, however, this speculation cannot be proven in the current study.…”

Section: Discussionmentioning

confidence: 89%

The effects of a pre-workout supplement containing caffeine, creatine, and amino acids during three weeks of high-intensity exercise on aerobic and anaerobic performance

Smith

Fukuda

Kendall

et al. 2010

Journal of the International Society of Sports Nutrition

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BackgroundA randomized, single-blinded, placebo-controlled, parallel design study was used to examine the effects of a pre-workout supplement combined with three weeks of high-intensity interval training (HIIT) on aerobic and anaerobic running performance, training volume, and body composition.MethodsTwenty-four moderately-trained recreational athletes (mean ± SD age = 21.1 ± 1.9 yrs; stature = 172.2 ± 8.7 cm; body mass = 66.2 ± 11.8 kg, VO2max = 3.21 ± 0.85 l·min-1, percent body fat = 19.0 ± 7.1%) were assigned to either the active supplement (GT, n = 13) or placebo (PL, n = 11) group. The active supplement (Game Time®, Corr-Jensen Laboratories Inc., Aurora, CO) was 18 g of powder, 40 kcals, and consisted of a proprietary blend including whey protein, cordyceps sinensis, creatine, citrulline, ginseng, and caffeine. The PL was also 18 g of powder, 40 kcals, and consisted of only maltodextrin, natural and artificial flavors and colors. Thirty minutes prior to all testing and training sessions, participants consumed their respective supplements mixed with 8-10 oz of water. Both groups participated in a three-week HIIT program three days per week, and testing was conducted before and after the training. Cardiovascular fitness (VO2max) was assessed using open circuit spirometry (Parvo-Medics TrueOne® 2400 Metabolic Measurement System, Sandy, UT) during graded exercise tests on a treadmill (Woodway, Pro Series, Waukesha, WI). Also, four high-speed runs to exhaustion were conducted at 110, 105, 100, and 90% of the treadmill velocity recorded during VO2max, and the distances achieved were plotted over the times-to-exhaustion. Linear regression was used to determine the slopes (critical velocity, CV) and y-intercepts (anaerobic running capacity, ARC) of these relationships to assess aerobic and anaerobic performances, respectively. Training volumes were tracked by summing the distances achieved during each training session for each subject. Percent body fat (%BF) and lean body mass (LBM) were assessed with air-displacement plethysmography (BOD POD®, Life Measurement, Inc., Concord, CA).ResultsBoth GT and PL groups demonstrated a significant (p = 0.028) increase in VO2max from pre- to post-training resulting in a 10.3% and 2.9% improvement, respectively. CV increased (p = 0.036) for the GT group by 2.9%, while the PL group did not change (p = 0.256; 1.7% increase). ARC increased for the PL group by 22.9% and for the GT group by 10.6%. Training volume was 11.6% higher for the GT versus PL group (p = 0.041). %BF decreased from 19.3% to 16.1% for the GT group and decreased from 18.0% to 16.8% in the PL group (p = 0.178). LBM increased from 54.2 kg to 55.4 kg (p = 0.035) for the GT group and decreased from 52.9 kg to 52.4 kg in the PL group (p = 0.694).ConclusionThese results demonstrated improvements in VO2max, CV, and LBM when GT is combined with HIIT. Three weeks of HIIT alone also augmented anaerobic running performance, VO2max and body composition.

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Section: Discussionmentioning

confidence: 89%

The effects of a pre-workout supplement containing caffeine, creatine, and amino acids during three weeks of high-intensity exercise on aerobic and anaerobic performance

Smith

Fukuda

Kendall

et al. 2010

Journal of the International Society of Sports Nutrition

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“…Twelve (12) individuals expressed interest in the study and took part in an initial telephone screen. Seventeen percent (17%) (n ϭ 2) of those screened by telephone were deemed ineligible to participate.…”

Section: Resultsmentioning

confidence: 99%

“…[11][12][13][14] Many of these reports mention reduction in overall stress, fatigue, and irritability-symptoms frequently associated with anxiety disorders, and in particular generalized anxiety disorder (GAD). GAD is a disabling and relatively common condition, with a lifetime prevalence between 5% and 7%.…”

Section: Introductionmentioning

confidence: 99%

A Pilot Study of Rhodiola rosea (Rhodax^®) for Generalized Anxiety Disorder (GAD)

Bystritsky

Kerwin²,

Feusner³

2008

The Journal of Alternative and Complementary Medicine

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“…It has long been known to have adaptogenic properties (Brekhman & Dardymov, 1969). Recently, researchers have found that it can elevate concentrations of norepinephrine, dopamine, and serotonin in the brain, act as a nicotinic cholinergic agonist in the central nervous system, reduce the level of C-reactive protein and creatinine kinase in the blood, increase the ATP content in the muscle mitochondria, and has antiarrhythmic activity, anti-prostate cancer activity, and antibacterial activity (Maslov et al, 1998;Abidov et al, 2003Abidov et al, , 2004Ming et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Salidroside on Hypoxia/Reoxygenation Injury by Sodium Hydrosulfite in PC12 Cells

Chen

Lü

Wang

et al. 2007

Pharmaceutical Biology

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Hypoxia=reoxygenation causes cellular injury and death associated with many pathophysiologic conditions, including respiratory disorders, myocardial ischemia, and tumour progression diseases. Neuronal pheochromocytoma (PC12) cells are widely used as a model system for neurologic research and are subject to chemical hypoxia induced with sodium hydrosulfite (Na 2 S 2 O 4 ), a common oxygen-consuming agent. Salidroside, which is the main active component of the famous traditional Chinese herb Rhodiola rosea L. (Crassulaceae), has been proved to possess many bioactivities. In this article, we studied the protective effects of salidroside on hypoxia= reoxygenation injury in PC12 cells induced by Na 2 S 2 O 4 . Cultures of PC12 cells were exposed for 1 h to 10 mM Na 2 S 2 O 4 for hypoxia, followed by reoxygenation for 2 h. The results showed that salidroside was very stable in medium and was not harmful to PC12 cells at the experimental concentrations of 0 $ 200 mg=mL. The cytoprotection by salidroside was dose-dependent, and the cell viability was 41.8 AE 5.7%, 62.4 AE 4.1%, and 92.2 AE 3.7% at 0, 50, and 100 mg=mL of salidroside, respectively. The level of released LDH significantly decreased from 513.5 AE 5.5% (without salidroside) to 258.1 AE 6.3% (with 100 mg=mL salidroside). Flow cytometry was performed to measure apoptotic rate. The results of flow cytometry assay indicated that the apoptotic rate was 17.0 AE 1.2% after hypoxia=reoxygenation injury. When the cells were treated with salidroside 12.5, 50 and 100 mg=mL, the apoptotic rate was 9.5 AE 0.9%, 7.4 AE 0.5%, and 4.5 AE 0.4%, respectively. In addition, our results were confirmed by inspection of cell morphology of PC12 cells. Treatment with salidroside (12.5, 50, 100 mg=mL) significantly prevented the cells from morphologic changes. All the above results showed salidroside could effectively protect PC12 cell against hypoxia=reoxygenation injury.

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Extract of Rhodiola rosea Radix Reduces the Level of C-Reactive Protein and Creatinine Kinase in the Blood

Cited by 39 publications

References 8 publications

The effects of a pre-workout supplement containing caffeine, creatine, and amino acids during three weeks of high-intensity exercise on aerobic and anaerobic performance

The effects of a pre-workout supplement containing caffeine, creatine, and amino acids during three weeks of high-intensity exercise on aerobic and anaerobic performance

A Pilot Study of Rhodiola rosea (Rhodax^®) for Generalized Anxiety Disorder (GAD)

Protective Effects of Salidroside on Hypoxia/Reoxygenation Injury by Sodium Hydrosulfite in PC12 Cells

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Extract of Rhodiola rosea Radix Reduces the Level of C-Reactive Protein and Creatinine Kinase in the Blood

Cited by 39 publications

References 8 publications

The effects of a pre-workout supplement containing caffeine, creatine, and amino acids during three weeks of high-intensity exercise on aerobic and anaerobic performance

The effects of a pre-workout supplement containing caffeine, creatine, and amino acids during three weeks of high-intensity exercise on aerobic and anaerobic performance

A Pilot Study of Rhodiola rosea (Rhodax®) for Generalized Anxiety Disorder (GAD)

Protective Effects of Salidroside on Hypoxia/Reoxygenation Injury by Sodium Hydrosulfite in PC12 Cells

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A Pilot Study of Rhodiola rosea (Rhodax^®) for Generalized Anxiety Disorder (GAD)