Extract of the mushroom Mycoleptodonoides aitchisonii induces a series of anti-oxidative and phase II detoxifying enzymes through activation of the transcription factor Nrf2

Kokubo, Takeshi; Taniguchi, Yoshimasa; Kanayama, Masaya; Shimura, Masako; Konishi, Yutaka; Kawagishi, Hirokazu; Yamamoto, Masayuki; Shindo, Kazutoshi; Yoshida, Aruto

doi:10.1016/j.foodchem.2011.04.031

Cited by 14 publications

(9 citation statements)

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“…Compounds 1 , 2 , and 5 were purified from the EtOAc-soluble part, and compounds 3 , 4 , and 6 – 8 were obtained from the CH 2 Cl 2 -soluble part. By comparison of the NMR data, mass spectra, and specific rotation of compounds 2 – 6 and 8 with those reported previously, − the six known compounds were identified as shown. Although 5 and 8 have been synthesized, − this is the first report of the isolation of these compounds from nature.…”

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confidence: 63%

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Endoplasmic Reticulum Stress Suppressive Compounds from the Edible Mushroom Mycoleptodonoides aitchisonii

et al. 2014

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confidence: 63%

“…The stereochemistry of compound 4 has not been previously reported. 12 In this study, the absolute configuration of 4 was determined as 3R, 4R, 1′R by X-ray crystallography analysis of its p-bromobenzoate (Figure 2).…”

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confidence: 93%

Endoplasmic Reticulum Stress Suppressive Compounds from the Edible Mushroom Mycoleptodonoides aitchisonii

et al. 2014

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“…Our results showed that sSCP 1 could not only scavenge DPPH·, hydroxyl radical and ABTS ·+ and antiglycation in vitro, but also elevated SOD and CAT activities and decreased MDA content of serum in vivo, it is a kind of idealer antioxidant. Some reports consider that to defense oxidative stress may be by activating specific, genetic or metabolic upstream signal pathways or down-regulating oxidative stress and cell apoptotic signal pathway to synthetize protein isoforms and lipids which are less sensitive to oxidation [ 45 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Selenylation Modification on Antioxidative Activities of Schisandra chinensis Polysaccharide

et al. 2015

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The selenylation modification of Schisandra chinensis polysaccharide (SCP) was conducted by the HNO3–Na2SeO3 method respectively under nine conditions according to L9(34) orthogonal design. Nine selenizing SCPs, sSCP1–sSCP9, were obtained, and their antioxidant activities were compared. In vitro test, the free radical-scavenging rates of nine sSCPs were determined for DPPH., .OH and ABTS+. sSCP1 presented the most significant effect, and could inhibit the nonenzymatic protein glycation. In vivo test, 14-day-old chickens were injected respectively with sSCP1 and SCP, the serum contents of CAT, SOD and MDA were determined. The result showed that as compared with the SCP group, the SOD and CAT activities were significantly or numerically raised and MDA content was significantly or numerically lowered in the sSCP1 group. These results indicate that selenylation modification can significantly enhance the antioxidant and antiglycative activity of SCP in vitro or in vivo. sSCP1 possesses the best efficacy and its modification conditions can be as optimal modification conditions that were 200 mg of Na2SeO3 for 500 mg of SCP, reaction temperature of 50°C and reaction time of 6 h.

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“…The Py-2-C bearing α- iso -butyl-acetic acid at the N -position was isolated along with 10 other compounds. The chemical structure of this Py-2-C ( 9 ) was determined by spectroscopic analyses [ 12 ]. Pyrrolezanthine ( 10 ) was first isolated from the edible mushroom Leccinum extremiorientale in 2011 [ 13 ].…”

Section: Naturally Occurring Pyrrole-2-carbaldehyde Derivativesmentioning

confidence: 99%

Pyrrole-2-carboxaldehydes: Origins and Physiological Activities

Matsugo

Nakamura

2023

Molecules

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Pyrrole-2-carboxaldehyde (Py-2-C) derivatives have been isolated from many natural sources, including fungi, plants (roots, leaves, and seeds), and microorganisms. The well-known diabetes molecular marker, pyrraline, which is produced after sequential reactions in vivo, has a Py-2-C skeleton. Py-2-Cs can be chemically produced by the strong acid-catalyzed condensation of glucose and amino acid derivatives in vitro. These observations indicate the importance of the Py-2-C skeleton in vivo and suggest that molecules containing this skeleton have various biological functions. In this review, we have summarized Py-2-C derivatives based on their origins. We also discuss the structural characteristics, natural sources, and physiological activities of isolated compounds containing the Py-2-C group.

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Extract of the mushroom Mycoleptodonoides aitchisonii induces a series of anti-oxidative and phase II detoxifying enzymes through activation of the transcription factor Nrf2

Cited by 14 publications

References 29 publications

Endoplasmic Reticulum Stress Suppressive Compounds from the Edible Mushroom Mycoleptodonoides aitchisonii

Endoplasmic Reticulum Stress Suppressive Compounds from the Edible Mushroom Mycoleptodonoides aitchisonii

Effects of Selenylation Modification on Antioxidative Activities of Schisandra chinensis Polysaccharide

Pyrrole-2-carboxaldehydes: Origins and Physiological Activities

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