Extraction of artemisinin and artemisinic acid from Artemisia annua L. using supercritical carbon dioxide

Köhler, Marcel; Haerdi, W.; Christen, Philippe; Veuthey, Jean‐Luc

doi:10.1016/s0021-9673(97)00403-2

Cited by 86 publications

(61 citation statements)

References 21 publications

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“…This compound is isolated from Artemisia annua L. which is mostly grown in Asia. Artemisinin mainly accumulates in the leaves and flower buds in concentrations in the range 0.01-1% w/w, depending on the plant origin, stage of development, and cultivation conditions [1][2][3][4][5] Due to its antimalarial activity, artemisinin has become available commercially as antimalarial drug [6][7][8][9] . Although this compound has been successfully synthesized, the synthesis is as expensive as the extraction of artemisinin from natural products.…”

Section: Artemisinin (mentioning

confidence: 99%

“…In past decades, even though such extraction techniques of artemisinin have been widely reported, yet no study has been conducted to provide a better understanding on how the compound behaves as different extraction techniques of artemisinin from A. annua are combined. Previous studies are based mainly on a single extraction technique 4,5 . Microwave-assisted extraction 5 or super critical CO 2 extraction procedures 4 have been used without comparing the results with other extraction methods.…”

Section: Artemisinin (mentioning

confidence: 99%

“…Previous studies are based mainly on a single extraction technique 4,5 . Microwave-assisted extraction 5 or super critical CO 2 extraction procedures 4 have been used without comparing the results with other extraction methods.…”

Section: Artemisinin (mentioning

confidence: 99%

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Khalil¹,

Darusman²,

Syafitri³

2011

ScienceAsia

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Fractional factorial design was applied to optimize the extraction process of artemisinin from Artemisia annua L. Three different techniques i.e., Soxhlet, maceration, and microwave-assisted extraction were optimized to determine the optimum extraction conditions. Thin layer chromatography and high performance liquid chromatography were used to determine the yield of artemisinin in the sample. The optimum condition was obtained by immersing 0.5 g of sample in 3 ml of chloroform for 2 min. The amount of artemisinin extracted from the sample was 47.9 ± 0.6 × 10 −3 % w/w. In addition, the predicted values calculated by the model were in good agreement with the experimental values.

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Section: Artemisinin (mentioning

confidence: 99%

Section: Artemisinin (mentioning

confidence: 99%

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Untitled

Khalil¹,

Darusman²,

Syafitri³

2011

ScienceAsia

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“…They showed that the highest selectivity towards artemisinin is reached with US-assisted extraction using hexane at 25 °C thus saving energy costs [21]. Another approach is demonstrated by Quispe-Condori et al [22], and Kohler et al [23]. Both groups extracted artemisinin successfully with supercritical carbon dioxide.…”

Section: Introductionmentioning

confidence: 99%

“…The fluid consisted of carbon dioxide and 3% of methanol at 50 • C and 150 bar. By analyzing the shape of the extraction curves, they concluded, that the extraction is not limited by diffusion but by the elution process [23]. Quispe-Condori et al performed a complete factorial design to optimize the extraction.…”

Section: Introductionmentioning

confidence: 99%

Systematic and Model-Assisted Evaluation of Solvent Based- or Pressurized Hot Water Extraction for the Extraction of Artemisinin from Artemisia annua L.

Sixt

Strube

2017

Processes

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Abstract:In this study, the solvent based extraction of artemisinin from Artemisia annua L. using acetone in percolation mode is compared to the method of pressurized hot water extraction. Both techniques are simulated by a physico-chemical process model. The model as well as the model parameter determination, including the thermal degradation of artemisinin are shown and discussed. For the conventional extraction, a solvent screening is performed considering various organic solvents. A temperature screening is presented for the systematic design of the pressurized hot water extraction. The best temperature with regards to thermal decomposition and high productivity was found to be 80 • C. Both, conventional percolation and Pressurized Hot Water Extraction (PHWE) are suitable for the extraction of artemisinin. The extraction curves show a high conformity with the simulation results.

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Supercritical fluid extraction and chromatography of artemisinin and artemisinic acid. An improved method for the analysis ofArtemisia annua samples

et al. 1997

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Artemisinin and artemisinic acid were extracted from aerial parts of Artemisia annua by supercritical fluid extraction (SFE) with carbon dioxide modified with 3% (v/v) methanol. The quantitative determination of both compounds was carried out by supercritical fluid chromatography (SFC) coupled with an evaporative light scattering detector (SFC‐ELSD). Results obtained by SFE‐SFC‐ELSD show that this method allows mild extraction conditions and quantitative determination without further purification of the plant extract. In all cases, artemisinin and artemisinic acid were extracted in a higher yield with supercritical carbon dioxide than with liquid‐solid extraction. © 1997 John Wiley & Sons, Ltd.

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Extraction of artemisinin and artemisinic acid from Artemisia annua L. using supercritical carbon dioxide

Cited by 86 publications

References 21 publications

Untitled

Untitled

Systematic and Model-Assisted Evaluation of Solvent Based- or Pressurized Hot Water Extraction for the Extraction of Artemisinin from Artemisia annua L.

Supercritical fluid extraction and chromatography of artemisinin and artemisinic acid. An improved method for the analysis ofArtemisia annua samples

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