Extraction of triterpenoids and phenolic compounds from <i>Ganoderma lucidum</i>: optimization study using the response surface methodology

Taofiq, Oludemi; Barros, Lillian; Prieto, Miguel A.; Heleno, Sandrina A.; Barreiro, María Filomena; Ferreira, Isabel C.F.R.

doi:10.1039/c7fo01601h

Cited by 62 publications

(39 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Other negative effects such as those between T or P and S may suggest that the further use of lower P , in combination with higher S , will avoid the anthocyanin degradation. The results are in accordance with others recently reported by other authors [19,20,21], in which inclined surfaces to the side of T or P may increase the solubility of target compounds by using stronger energies, and consequently improve their release from the sample matrix, while destroying the integrity of connective and structural tissues.…”

Section: Resultssupporting

confidence: 93%

Ultrasound as a Rapid and Low-Cost Extraction Procedure to Obtain Anthocyanin-Based Colorants from Prunus spinosa L. Fruit Epicarp: Comparative Study with Conventional Heat-Based Extraction

et al. 2019

Self Cite

View full text Add to dashboard Cite

An ultrasound rapid and low-cost procedure for anthocyanin-based colorants from Prunus spinosa L. fruit epicarp was developed, and the advantages were compared with conventional heat-based extraction. To obtain the conditions that maximize anthocyanins’ extraction, a response surface methodology was applied using the variables of time, temperature, and ethanol content, in the case of heat extraction, whereas for ultrasound assisted extraction, temperature was replaced by ultrasound power. Two anthocyanin compounds were identified by HPLC-DAD-ESI/MS—namely, cyanidin 3-rutinoside and peonidin 3-rutinoside. The responses used were the extraction yield and the content of the identified anthocyanins. Ultrasound extraction was the most effective method at 5.00 ± 0.15 min, 400.00 ± 32.00 W, and 47.98% ± 2.88% of ethanol obtaining 68.60% ± 2.06% of extracted residue, with an anthocyanin content of 18.17 mg/g (extract-basis) and 11.76 mg/g (epicarp-basis). Overall, a viable green process was achieved that could be used to support pilot-scale studies for industrial production of anthocyanin-based colorants from P. spinosa fruit epicarp.

show abstract

Section: Resultssupporting

confidence: 93%

Ultrasound as a Rapid and Low-Cost Extraction Procedure to Obtain Anthocyanin-Based Colorants from Prunus spinosa L. Fruit Epicarp: Comparative Study with Conventional Heat-Based Extraction

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…In general, the solvent extraction process is of great importance to conduct qualitative and quantitative analysis of active ingredients from plants or herbs. However, the composition of the extraction products and the extraction rate of the target products are affected by many factors, particularly extraction factors including method, solvent, time, temperature and liquid–solid ratio [27]. Usually, the traditional liquid–solid extraction methods such as percolation, impregnation, decoction, reflux and Soxhlet extraction consume large amounts of solvents and energy.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Optimization of Ultrasound-Assisted Extraction for Flavonoids and Antioxidant Activity of Angelica keiskei Using Response Surface Methodology (RSM)

et al. 2019

View full text Add to dashboard Cite

Angelica keiskei Koidzumi (A. keiskei), as a Japanese edible herbal plant, enjoys a variety of biological activities due to the presence of numerous active compounds, especially flavonoids. This study aims for the optimization of ultrasound-assisted extraction (UAE) for flavonoids in A. keiskei and their antioxidant activity by using the response surface methodology (RSM). Single-factor experiments and a four-factor three-level Box–Behnken design (BBD) were performed to explore the effects of the following parameters on flavonoid extraction and antioxidant activity evaluation: ultrasonic temperature (X1), ultrasonic time (X2), ethanol concentration (X3) and liquid–solid ratio (X4). The optimum conditions of the combination of total flavonoid content (TFC), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capacity (DPPH-RSC) and ferric-reducing antioxidant power (FRAP) were as follows: X1 = 80 °C, X2 = 4 min, X3 = 78%, X4 = 35 mL/g, respectively. The experimental results provide a theoretical basis for the extensive utilization of A. keiskei and flavonoids extraction from A. keiskei as a potential source of antioxidants.

show abstract

“…We are the first to optimize extraction conditions for the maximum in vitro antioxidant activity of AAE using RSM studies. As described by Box and Wilson, RSM is a statistical tool employed to predict an optimum response against several input process variables (Oludemi et al., 2018). Optimization results of current investigation revealed that maximum in vitro antioxidant activity can be achieved up to the extraction temperature of 60 °C and extraction time of 36 hr.…”

Section: Resultsmentioning

confidence: 99%

Optimization of extraction conditions of Angelica archangelica extract and activity evaluation in experimental fibromyalgia

Kaur

Singh

Bhatti

2020

Journal of Food Science

View full text Add to dashboard Cite

The plant Angelica archangelica, owing to its magnificent therapeutic effectiveness in folklore medicine system, has been regarded as an “angel plant.” The current investigation was aimed to optimize extraction conditions of A. archangelica roots and to investigate in vivo role of optimized extract in fibromyalgia. Plant material (dried roots) was subjected to methanol extraction at variable temperature (40 to 60 °C) and time (12 to 36 hr) conditions as per two‐factorial design strategy, and responses in terms of antioxidant activity were determined. The optimized extraction conditions were found to be temperature of 60 °C and time of 36 hr. HPLC fingerprinting indicated the presence of coumarins in extract. To induce fibromyalgia, the mice were administered reserpine at a dose of 0.5 mg/kg. Mice were orally treated with 100, 200, and 400 mg/kg extract, and magnitude of fibromyalgia was quantified. In comparison to reserpine group, the extract treatment attenuated pain as shown by significant increase in paw withdrawal threshold against mechanical stimuli (P < 0.05), improved motor ability indicated by increase in fall‐off time in inclined plane test (P < 0.05), improved locomotion indicated by increased square crossings in open field test (P < 0.05), and improved cognition as shown by significant reduction in time to reach platform in Morris water maze test and passive avoidance task test (P < 0.05). Extract treatment significantly halted reserpine‐induced rise in serum cytokine level (P < 0.05) and brain oxidative stress (P < 0.05). Angelica archangelica extract exerted its beneficial effects in fibromyalgia possibly through the attenuation of oxidative stress‐mediated inflammatory cascade. Practical Application Leads from natural products have become an integral part of drug designing processes and have high acceptability due to their better tolerance. The optimization of extraction conditions of plant yields better results and could reduce the processing time, thus increasing its industrial value.

show abstract

Extraction of triterpenoids and phenolic compounds from Ganoderma lucidum: optimization study using the response surface methodology

Cited by 62 publications

References 46 publications

Ultrasound as a Rapid and Low-Cost Extraction Procedure to Obtain Anthocyanin-Based Colorants from Prunus spinosa L. Fruit Epicarp: Comparative Study with Conventional Heat-Based Extraction

Ultrasound as a Rapid and Low-Cost Extraction Procedure to Obtain Anthocyanin-Based Colorants from Prunus spinosa L. Fruit Epicarp: Comparative Study with Conventional Heat-Based Extraction

Simultaneous Optimization of Ultrasound-Assisted Extraction for Flavonoids and Antioxidant Activity of Angelica keiskei Using Response Surface Methodology (RSM)

Optimization of extraction conditions of Angelica archangelica extract and activity evaluation in experimental fibromyalgia

Contact Info

Product

Resources

About