Extractive-spectrophotometric methods for determination of anti-Parkinsonian drug in pharmaceutical formulations and in biological samples using sulphonphthalein acid dyes

Omara, Hany A.; Amin, Alaa S.

doi:10.1016/j.jscs.2010.11.001

Cited by 12 publications

(7 citation statements)

References 38 publications

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“…[6] High performance liquid chromatographic methods coupled with fluorescence detection have been reported in the literature for the quantification of MEM in rat plasma, [7,8] human plasma. [9][10][11] Determination of memantine in human plasma by liquid chromatography with mass spectrometry (LC-MS), [12][13][14][15] gas chromatography with mass spectrometry (GC-MS) [16] and micellar electro kinetic chromatography (MEKC) [17], extractive-Spectrophotometric [18] oxidation-reduction reaction-spectrophotometric [19] or Potentiometrically [20,21].…”

Section: Scheme 1 Structure Of Memantine Hydrochloride (Mem)mentioning

confidence: 99%

Spectrophotometric Determination of Alzheimer’s Drug, Memantine Hydrochloride in Biological Samples Using Ninhydrin and Ferric Chloride

Omara¹

2017

IOSR JAC

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Section: Scheme 1 Structure Of Memantine Hydrochloride (Mem)mentioning

confidence: 99%

Spectrophotometric Determination of Alzheimer’s Drug, Memantine Hydrochloride in Biological Samples Using Ninhydrin and Ferric Chloride

Omara¹

2017

IOSR JAC

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“…Bromothymol blue (BTB) ( Figure 1(d) ) is an anionic dye and that can be protonated or deprotonated to form yellow or blue, respectively. The BTB was used to make ion-pair complex, which was applied to determine many pharmaceutical compounds by extractive spectrophotometric methods [ 21 – 30 ]. However, the ion-pair complex between BTB and FQs has not been studied.…”

Section: Introductionmentioning

confidence: 99%

Determination of Fluoroquinolones in Pharmaceutical Formulations by Extractive Spectrophotometric Methods Using Ion-Pair Complex Formation with Bromothymol Blue

Dung

Dong

et al. 2018

Journal of Analytical Methods in Chemistry

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In this paper, we reported a new, simple, accurate, and precise extractive spectrophotometric method for the determination of fluoroquinolones (FQs) including ciprofloxacin (CFX), levofloxacin (LFX), and ofloxacin (OFX) in pharmaceutical formulations. The proposed method is based on the ion-pair formation complexes between FQs and an anionic dye, bromothymol blue (BTB), in acidic medium. The yellow-colored complexes which were extracted into chloroform were measured at the wavelengths of 420, 415, and 418 nm for CFX, LFX, and OFX, respectively. Some effective conditions such as pH, dye concentration, shaking time, and organic solvents were also systematically studied. Very good limit of detection (LOD) of 0.084 µg/mL, 0.101 µg/mL, and 0.105 µg/mL were found for CFX, LFX, and OFX, respectively. The stoichiometry of the complexes formed between FQs and BTB determined by Job's method of continuous variation was 1 : 1. No interference was observed from common excipients occurred in pharmaceutical formulations. The proposed method has been successfully applied to determine the FQs in some pharmaceutical products. A good agreement between extractive spectrophotometric method with high-performance liquid chromatography mass spectrometry (HPLC-MS) for the determination of FQs in some real samples demonstrates that the proposed method is suitable to quantify FQs in pharmaceutical formulations.

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“…The chemical structure of AMN, Figure , shows that it lacks the minimal double bond conjugation necessary for adequate UV/visible absorbance above 200 nm, which was the main reason behind the absence of a direct spectrophotometric methods or HPLC methods coupled to the commonly used spectrophotometric detectors; therefore, derivatization procedures were mandatory for its spectrophotometric determination, − HPLC-fluorescence − and HPLC-UV detection. Amantadine was also determined in plasma using liquid chromatography–mass spectrometry , and by gas chromatography .…”

Section: Introductionmentioning

confidence: 99%

Green in-Line Ion Selective Electrode Potentiometric Method for Determination of Amantadine in Dissolution Media and in Pharmaceutical Formulations

Elzanfaly

Saad

2017

ACS Sustainable Chem. Eng.

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Amantadine HCl (AMN) is a well-known antiviral agent. Chemically, AMN chromophore privation leads to the absence of UV-absorbance, a condition that hinders direct spectrophotometric or simple chromatographic determination using common detectors without prior derivatization steps. In this work, an environmentally friendly ion selective electrode (ISE) method was developed for the determination of AMN, and measurements were carried out directly in the aqueous solution of the sample without pretreatment or derivatization steps. PVC-membranes were fabricated using nitrophenyl octyl ether as a plasticizer along with different cation exchangers, responses were compared, and that containing phosphomolybdic acid proved to have the best near-Nernstian slope through a wide linear range (4.57 × 10–7)–(1.0 × 10–2) M. The ion pair was obtained by soaking the membrane sensor in a 1 × 10–2 M solution of AMN. The sensor was able to determine AMN in colored and turbid solutions of its tablets and capsules without prior extraction, pretreatment, filtration, or derivatization steps. Additionally, the sensor was successfully applied as a benchtop real-time inline analyzer in dissolution monitoring experiments from its capsules and tablets formulations as per the recommended USP and FDA regulations, respectively, where no sample withdrawal, pretreatment, or filtration was required. Sensor response was validated as per IUPAC recommendations. The proposed technique provided a green eco-friendly method that saves cost, time, and effort and consumes the least amount of chemicals.

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Extractive-spectrophotometric methods for determination of anti-Parkinsonian drug in pharmaceutical formulations and in biological samples using sulphonphthalein acid dyes

Cited by 12 publications

References 38 publications

Spectrophotometric Determination of Alzheimer’s Drug, Memantine Hydrochloride in Biological Samples Using Ninhydrin and Ferric Chloride

Spectrophotometric Determination of Alzheimer’s Drug, Memantine Hydrochloride in Biological Samples Using Ninhydrin and Ferric Chloride

Determination of Fluoroquinolones in Pharmaceutical Formulations by Extractive Spectrophotometric Methods Using Ion-Pair Complex Formation with Bromothymol Blue

Green in-Line Ion Selective Electrode Potentiometric Method for Determination of Amantadine in Dissolution Media and in Pharmaceutical Formulations

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