Extragastrointestinal stromal tumor of lesser omentum: a challenging radiological and histological diagnosis

Trombatore, Claudia; Palmucci, Stefano; Angelico, Giuseppe; Vasquez, Enrico; Petrillo, Giuseppe; Puleo, Stefano; Cataldo, Antonio Di

doi:10.1016/j.clinimag.2015.07.007

Cited by 11 publications

(9 citation statements)

References 17 publications

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“…Literature search of MEDLINE was performed for all articles in English published from 1998 through 2015. MEDLINE search resulted in 47 case reports 8 9 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 including 57 patients and 6 case series 61 62 63 64 65 66 including 40 cases. As a result, a total of 99 omental GISTs patients were identified.…”

Section: Methodsmentioning

confidence: 99%

Clinicopathological features and prognosis of omental gastrointestinal stromal tumor: evaluation of a pooled case series

Feng

Tian

Liu

et al. 2016

Sci Rep

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Clinicopathological features and prognosis of omental GISTs are limited due to the extremely rare incidence. Therefore, the aim of the present study was to investigate the clinicopathological features and prognosis of omental GISTs. Omental GISTs cases were obtained from our center and from case reports and clinical studies extracted from MEDLINE. Clinicopathological features and survivals were analyzed. A total of 99 cases of omental GISTs were enrolled in the present study. Omental GISTs occurred predominantly in greater omentum (78/99, 78.8%). The majority of tumors exceeded 10 cm in diameter (67/98, 68.3%) and were high risk (88/96, 91.7%). Histological type was correlated with tumor location and mutational status. The five year DFS and DSS was 86.3% and 80.6%, respectively. Mitotic index was risk factor for prognosis of omental GISTs. Prognosis of omental GISTs was worse than that of gastric GISTs by Kaplan-Meier analysis. However, multivariate analysis showed that the prognosis was comparable between the two groups. The majority of omental GISTs were large and high risk. Mitotic index was risk factor for prognosis of omental GISTs. The prognosis was comparable between omental and gastric GISTs.

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Section: Methodsmentioning

confidence: 99%

Clinicopathological features and prognosis of omental gastrointestinal stromal tumor: evaluation of a pooled case series

Feng

Tian

Liu

et al. 2016

Sci Rep

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“…As Table 1 shows, four cases of GIST of the lesser omentum, including our case, were misdiagnosed as extramucosal tumors of the stomach [3–5]. Additionally, two cases of GIST of the lesser omentum were followed up as a diagnosis of benign hepatic tumor without surgery [6, 7]. Trombatore et al [7] reported a case with rapid growth on CT and MRI after a 16-month follow-up period.…”

Section: Discussionmentioning

confidence: 97%

“…[10]79FTumor of the pancreas110SpindleNoneTrombatore et al . [7]69FHepatic hemangioma110EpithelioidNonePresent case72FGIST of the stomach35SpindleNoneNA = not applicable; GIST = gastrointestinal stromal tumor.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, two cases of GIST of the lesser omentum were followed up as a diagnosis of benign hepatic tumor without surgery [6, 7]. Trombatore et al [7] reported a case with rapid growth on CT and MRI after a 16-month follow-up period. Therefore, we should also include GIST of the lesser omentum in the differential diagnosis of abdominal masses when the lesion shows features that are uncommon for GIST, such as a location in the lesser omentum but outside the gastrointestinal tract.…”

Section: Discussionmentioning

confidence: 99%

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Gastrointestinal stromal tumor of the lesser omentum: a case report and review of the literature

Ninomiya¹,

Hiroishi²,

Shiromizu³

et al. 2019

Journal of Surgical Case Reports

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A 72-year-old woman visited our hospital for a routine health examination and underwent abdominal ultrasonography, which revealed an intra-abdominal tumor. Abdominal computed tomography and magnetic resonance imaging showed a well-defined solid mass of ~3 cm in diameter lying adjacent to the stomach. The mass was preoperatively diagnosed as gastrointestinal stromal tumor of the stomach. At laparotomy, a well-encapsulated tumor was found in the lesser omentum. It was slightly adherent to the stomach wall but was removed without difficulty. Therefore, only enucleation of the tumor was performed. The excised tumor, which was 35 × 30 × 25 mm3 in size, had a white cut surface without necrosis or hemorrhage. According to the pathological findings, the tumor was classified as a very low-risk gastrointestinal stromal tumor originating in the lesser omentum. Gastrointestinal stromal tumor of the lesser omentum is very rare, and surgical resection is the only effective treatment modality.

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“…EGISTs are extremely rare neoplasm, which account for less than 5% in large series of stromal tumors. Although EGISTs seem to have morphological and immunohistochemical similarities with GISTs, their pathogenesis, incidence, and prognosis are not completely known because they are very rare [8]. Recently, Yamamoto et al [2] reported mutational status of EGISTs, that the pattern of KIT and PDGFRA mutations in EGISTs were similar to that in GIST.…”

Section: Discussionmentioning

confidence: 99%

Primary Extragastrointestinal Stromal Tumor of Retroperitoneum: Poor Response to Tyrosine Kinase Inhibitor

Lee

2018

Soonchunhyang Med Sci

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Gastrointestinal stromal tumors (GIST) are the most common sarcomas arising in the gastrointestinal tract. Stromal tumors arising outside the gastrointestinal tract are known as extragastrointestinal stromal tumors (EGIST). EGISTs may occur in omentum, mesentery, or retroperitoneum and are histologically and immunophenotypically similar to that in GISTs. EGISTs are very rare, so pathogenesis, incidence, and prognosis of EGISTs are not defined yet. In particular, there are a few reported literatures on the treatment of metastatic EGISTs. I report a case of a primary EGIST of the retroperitoneum with lung metastasis surgically removed and treated with tyrosine kinase inhibitor.

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Extragastrointestinal stromal tumor of lesser omentum: a challenging radiological and histological diagnosis

Cited by 11 publications

References 17 publications

Clinicopathological features and prognosis of omental gastrointestinal stromal tumor: evaluation of a pooled case series

Clinicopathological features and prognosis of omental gastrointestinal stromal tumor: evaluation of a pooled case series

Gastrointestinal stromal tumor of the lesser omentum: a case report and review of the literature

Primary Extragastrointestinal Stromal Tumor of Retroperitoneum: Poor Response to Tyrosine Kinase Inhibitor

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