Extragonadal Effects of Follicle-Stimulating Hormone on Osteoporosis and Cardiovascular Disease in Women during Menopausal Transition

Zhu, Dongxing; Li, Xiaosa; MacRae, Vicky; Simoncini, Tommaso; Fu, Xiaodong

doi:10.1016/j.tem.2018.06.001

Cited by 56 publications

(50 citation statements)

References 82 publications

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“…Although the FSH ( β = −10.81, p = 0.037) and estradiol ( β = 46.23, p = 0.043) levels were statistically different, all values remained normal ranges for peri- or post-menopausal women (lower part of Table 2 ). We note that, the FSH level rises above 40 mIU/mL during menopause [ 30 ], while estradiol level decreases from 30 to 400 pg/mL to 0–30 pg/mL [ 31 ]. We also note that the changes were opposite in the placebo and KM groups, indicating a potential protective capacity KM to suppress the hormonal changes in menopause.…”

Section: Resultsmentioning

confidence: 99%

Efficacy and Safety of Kudzu Flower–Mandarin Peel on Hot Flashes and Bone Markers in Women during the Menopausal Transition: A Randomized Controlled Trial

et al. 2020

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This randomized controlled study aimed to assess the efficacy and safety of an extract mixture of kudzu flower and mandarin peel (KM) on hot flashes (HFs) and markers of bone turnover in women during the menopausal transition. Healthy women aged 45–60 years with the menopausal HFs were randomly assigned in a 1:1 ratio to either KM (1150 mg/day) or placebo arms for 12 weeks (n = 84). The intent-to-treat analysis found that compared with the placebo, the KM significantly attenuated HF scores (p = 0.041) and HF severities (p < 0.001), with a mean difference from baseline to week 12. The KM also improved bone turnover markers, showing a significant reduction in bone resorption CTx (p = 0.027) and a tendency of increasing bone formation OC relative to the placebo. No serious adverse events and hormonal changes were observed in both groups. These findings suggest that KM consumption may improve the quality of life in ways that are important to symptomatic menopausal women.

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Section: Resultsmentioning

confidence: 99%

Efficacy and Safety of Kudzu Flower–Mandarin Peel on Hot Flashes and Bone Markers in Women during the Menopausal Transition: A Randomized Controlled Trial

et al. 2020

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“…Natural menopause causes altered expression of progesterone, testosterone and estrogen, while these hormones, such as estrogen can regulate the expression of certain lncRNAs [16,17]. In addition, the development of osteoporosis after menopause is also affected by dysregulated expression of hormones [18]. Therefore, the down-regulated SNHG1 after menopause and during the development of osteoporosis may be also caused by the changed levels of hormones.…”

Section: Discussionmentioning

confidence: 99%

LncRNA SNHG1 was down-regulated after menopause and participates in postmenopausal osteoporosis

et al. 2019

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The functions of long (>200 nt) non-coding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) have only been investigated in cancer biology. We found that plasma LncRNA SNHG1 was down-regulated in postmenopausal than in premenopausal females. Among postmenopausal females, the ones with postmenopausal osteoporosis showed much lower expression levels of plasma lncRNA SNHG1. A 6-year follow-up study on postmenopausal females revealed that plasma lncRNA SNHG1 decreased in females with postmenopausal osteoporosis but not in healthy postmenopausal females. Levels of plasma lncRNA SNHG1 at 12 months before diagnosis is sufficient to distinguish postmenopausal osteoporosis patients from healthy controls. After treatment, plasma lncRNA SNHG1 were significantly up-regulated. Therefore, lncRNA SNHG1 was down-regulated after menopause and plasma level of lncRNA SNHG1 may serve as a biomarker for the diagnosis and treatment of postmenopausal osteoporosis.

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“…It is possible that the accelerated rise in FSH across the menopause transition may have independent adverse effects on the vasculature (Zhu et al. ). A recent study demonstrated that administration of FSH increased atherosclerotic lesions and serum concentrations of vascular cell adhesion molecule‐1 (VCAM‐1) in ovariectomized ApoE knockout mice, which was independent of estrogen deficiency.…”

Section: Discussionmentioning

confidence: 99%

Retrograde and oscillatory shear increase across the menopause transition

et al. 2019

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Declines in endothelial function can take place rapidly across the menopause transition, placing women at heightened risk for atherosclerosis. Disturbed patterns of conduit artery shear, characterized by greater oscillatory and retrograde shear, are associated with endothelial dysfunction but have yet to be described across menopause. Healthy women, who were not on hormone therapy or contraceptives, were classified into early perimenopausal, late perimenopausal, and early postmenopausal stage. Resting antegrade, retrograde, and oscillatory shear were calculated from blood velocity and diameter measured in the brachial and common femoral artery using Doppler ultrasound. Serum was collected for measurements of estradiol, follicle‐stimulating hormone (FSH), and luteinizing hormone. After adjusting for age, brachial artery oscillatory shear was significantly higher in early postmenopausal women (n = 15, 0.17 ± 0.08 a.u.) than both early (n = 12, 0.08 ± 0.05 a.u., P < 0.05) and late (n = 8, 0.08 ± 0.04 a.u) perimenopausal women, and retrograde shear was significantly greater in early postmenopausal versus early perimenopausal women (−19.47 ± 12.97 vs. −9.62 ± 6.11 sec−1, both P < 0.05). Femoral artery oscillatory and retrograde shear were greater, respectively, in early postmenopausal women (n = 15, 0.19 ± 0.08 a.u.; −13.57 ± 5.82 sec−1) than early perimenopausal women (n = 14, 0.11 ± 0.08 a.u.; −8.13 ± 4.43 sec−1, P < 0.05). Further, Pearson correlation analyses revealed significant associations between FSH and both retrograde and oscillatory shear, respectively, in the brachial (r = −0.40, P = 0.03; r = 0.43, P = 0.02) and common femoral artery (r = −0.45, P = 0.01; r = 0.56, P = 0.001). These results suggest menopause, and its associated changes in reproductive hormones, adversely influences conduit arterial shear rate patterns to greater oscillatory and retrograde shear rates.

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Extragonadal Effects of Follicle-Stimulating Hormone on Osteoporosis and Cardiovascular Disease in Women during Menopausal Transition

Cited by 56 publications

References 82 publications

Efficacy and Safety of Kudzu Flower–Mandarin Peel on Hot Flashes and Bone Markers in Women during the Menopausal Transition: A Randomized Controlled Trial

Efficacy and Safety of Kudzu Flower–Mandarin Peel on Hot Flashes and Bone Markers in Women during the Menopausal Transition: A Randomized Controlled Trial

LncRNA SNHG1 was down-regulated after menopause and participates in postmenopausal osteoporosis

Retrograde and oscillatory shear increase across the menopause transition

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