Extramammary Paget's disease arising in a mature cystic teratoma of the ovary

Extramammary Paget's disease arising in a mature cystic teratoma of the ovary: Immunohistochemical expression of androgen receptor

“…and Zaino 6 respectively showed undifferentiated carcinoma and invasive adenocarcinoma in the underlying tissue, the cases reported by Shimizu et al 4 . and Monteagudo et al ., 5 as well as our case, did not have components of invasive adenocarcinoma.…”

“…3-5 An example of a similar lesion arising in retroperitoneal teratoma was also described by Zaino. 6 Whereas the cases reported by Randall et al 3 and Zaino 6 respectively showed undifferentiated carcinoma and invasive adenocarcinoma in the underlying tissue, the cases reported Pathology International 2011; 61: 498-500 doi:10.1111/j.1440-1827.2011.02692.x by Shimizu et al 4 and Monteagudo et al, 5 as well as our case, did not have components of invasive adenocarcinoma. The expression of sex hormone receptors has not been investigated to date in extramammary Paget's disease arising in teratoma.…”

“…Recent evidence has indicated that extramammary Paget's disease without underlying adenocarcinoma originates from intraepidermal cells of apocrine gland ducts or from pluripotent keratinocyte stem cells 2 . To our knowledge, there have been only three case reports describing extramammary Paget's disease arising in mature cystic teratoma of the ovary 3–5 . An example of a similar lesion arising in retroperitoneal teratoma was also described by Zaino 6 .…”

Extramammary Paget Disease in a Retrorectal Dermoid Cyst

“…21,32 The most common malignancies to arise from mature teratomas in other sites are squamous carcinoma, carcinoid tumor, and adenocarcinoma. 5,14,18 Three cases of EMP have been reported within mature cystic (monodermal) teratomas of the ovary 24,27,30 and one case has been reported in a retroperitoneal teratoma, 35 but none to our knowledge within monodermal teratomas in the retrorectal/presacral area.…”