Extramedullary plasmacytoma, a report of five cases diagnosed by FNAC

Abstract

Extramedullary plasmacytoma may occur either as an initial presentation or as a secondary involvement by multiple myeloma. Fine needle aspiration is a reliable technique for its rapid diagnosis.

EBV-Positive Plasmacytoma of the Submandibular Gland—Report of a Rare Case with Molecular Genetic Characterization

“…Our case highlights a potential pitfall that may occur on FNAC examination of plasmacytomas particularly if they arise in unusual sites such as in the case presented herein. Although FNAC of plasma cell neoplasms generally demonstrates typical plasmacytoid cells with abundant finely granular cytoplasm and eccentric nuclei containing fine chromatin and indistinct nucleoli, occasionally numerous bare nuclei are encountered which may give rise to diagnostic difficulties [4], as illustrated in our case. The very occasional plasma cells that were present in our FNAC did not raise a suspicion of a plasma cell neoplasm initially.…”

Plasmacytoid morphology of poorly differentiated thyroid carcinoma: Diagnostic approach with a brief review of the literature

“…Hürthle cell variant of papillary carcinoma may show nuclear irregularity with grooving and inclusions, which help in the categorisation of the tumour. Two other haematolymphoid malignancies that can cause diagnostic confusion with the plasmacytoid PDTC are plasma cell neoplasm in the thyroid or a low‐grade marginal zone lymphoma with plasmacytic differentiation. Plasma cell neoplasm can rarely manifest as extramedullary plasmacytoma of thyroid or the more common myelomatous infiltration of thyroid.…”

“…The chromatin was uniformly distributed and many tumour cells showed distinct nucleoli. No nuclear membrane irregularity or intranuclear inclusions were noted ( Figure 1A Plasma cell neoplasm [10][11][12] Lymphoma (MZL with plasmacytic differentiation/lymphoplasmacytic lymphoma) 13 1 Table 1) may be necessary to arrive at a correct diagnosis and minimise the use of IHC markers.…”

Plasma cell tumors with neurologic symptoms: Cytological findings

“…In cytology, plasma cell tumors should be differentiated from other lesions having plasma cells such as plasma cell granuloma, chronic granulomatous inflammation, Non‐Hodgkin's lymphoma, and mixed cellularity type of Hodgkin's disease 15–18…”

“…Lymphoglandular bodies are frequently seen in the Romanovsky stained cytological smears of high‐grade non‐Hodgkin lymphoma (NHL), but rarely seen in cytological smears of plasmacytoma. NHL B‐cell type is composed of large round immunoblasts with round nuclei, several small nucleoli, and scant cytoplasm 15–18…”