Extraneous Lymphocytic Hl-a Antigens in Severe Combined Immunodeficiency Disease

Terasaki, Paul I.; Miyajima, T; Sengar, D. P. S.; Stiehm, E. Richard

doi:10.1097/00007890-197203000-00009

Cited by 22 publications

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“…In this hypothesis, after gene duplication the membrane-bound HL-A antigens would have evolved in an autorecognition or immune surveillance function, while immunoglobulins evolved as a defense against invading microorganisms. Reported changes in the expression of HL-A antigens in malignancy (2)(3)(4), in continuous cell line cultures (5)(6)(7)(8)(9), and in immune deficiency diseases (10) ulated lymphocytes (PHAL's) were generated by culture of PBL's with phytohemagglutinin (Difco, PHA-P) for variable periods of time and PHA concentration. These cells were cultured at 2 X 106 cells per ml in RPMI 1640 medium with 10% fetal calf serum, penicillin, and streptomycin (ABS), and a 5% CO2 environment.…”

mentioning

confidence: 99%

Enhanced representation of HL-A antigens on human lymphocytes after mitogenesis induced by phytohemagglutinin or Epstein-Barr virus.

McCune¹,

Humphreys²,

Yocum³

et al. 1975

Proc. Natl. Acad. Sci. U.S.A.

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The amount of HL-A antigens present on the peripheral blood lymphocytes of a single human donor was increased about 11-fold after stimulation with phytohemagglutinin and 36-fold after transformation with Epstein-Barr virus. This increase applied to all four HL-A specificities of these cells. The response to phytohemagglutinin was dependent on dose and was first observed at 12 hr of incubation. Measurements of the amount of surface membranes by geometry, by radioiodinatable surface proteins, and by 5'-nucleotidase (5'-ribonucleotide phosphohydrolase, EC 3.1.3.5) assay all indicated that the enhanced representation of HL-A antigens after stimulation by phytohemagglutinin or transformation by Epstein-Barr virus must be due to an increase in the density of these antigens on the cell surface.

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confidence: 99%

Enhanced representation of HL-A antigens on human lymphocytes after mitogenesis induced by phytohemagglutinin or Epstein-Barr virus.

McCune¹,

Humphreys²,

Yocum³

et al. 1975

Proc. Natl. Acad. Sci. U.S.A.

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“…28, and At the present time any discussion concerning the mechanism of formation of these antibodies can only be speculative. It is pertinent to recall that lymphocytotoxic antibodies, related or not to HL-A, have been reported in nontransfused, nulliparous human subjects with a variety of diseases (Mittal et al 1970, Mottironi & Terasaki 1970, Waters et al 1971. However, some of these antibodies are more reactive at 15' C ("cold" antibodies) than at room temperature (Mottironi & Terasaki 1970), while normal rabbit lymphocytotoxins appear to be more reactive at room temperature.…”

Section: Table 2 Coeficients Of Correlation ( R ) Between Lymphocytotmentioning

confidence: 99%

Specificity of Lymphocytotoxic Anti‐Human Antibodies in Normal Rabbit Sera

et al. 1973

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Forty‐nine of 127 normal sera from New Zealand white rabbits were found to contain cytotoxic antibodies against human lymphocytes. Reactions with these sera did not correlate with those of known HL–A or ABO specificities. However, four distinct specificities were found in 18 sera. These antibodies are labile upon prolonged storage at −20°C and heating at 56°C for 30 min and have low avidity. Since rabbit serum is the most efficient source of complement in the cytotoxic reaction with human lymphocytes, the quantity as well as the specificity of these natural antibodies in rabbit serum have to be considered when selecting this reagent for the lymphocytotoxic test.

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“…(2) Lymphocyte polyreactivity, i.e. the lymphocytes display a positive cytotoxic reaction with a number of different HLA specificities so that the former are shown as carriers of more than four HLAantigens (Davey et al, 1974;Delmas-Marsalet et al, 1974;Evans & Pegrum, 1973;Majsky et al, 1975a;Terasaki et al, 1972;Walford et al, 1973Walford et al, , 1975.…”

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confidence: 99%

“…The alterations of HLA antigens are most frequently observed in acute and chronic leukaeniias of various types, in lyrnphogranuloma, reticulosis, lymphosarcoma, malignant tumours, as well as in immunodeficiency disease (Terasaki et al, 1972). glomerulonephritis and urzemia (Nelson et al, 1974).…”

mentioning

confidence: 99%

Chemotherapy—one of the Causes of Transient Loss of Hla Antigens and Lymphocyte Polyreactivity in Patients With Blood Diseases and Malignancies

Májský

Jakoubková

Abrahámová

1976

Int J Immunogenetics

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SUMMARY Modifications of HLA antigens (transient loss or polyreactivity) were found in thirty‐two of fifty‐five examined patients with blood diseases (leukaemia, reticulosis, reticulo‐ and lymphosarcoma, lymphogranuloma, erythroblastoma) and malignant tumours. In two cases of acute myelosis transient alteration of HLA‐A 2 antigen in HLA‐A 28 was demonstrated. The relationship of HLA antigenic modification to chemotherapy was established, both by analysis of individual cases and by statistical evaluation of serological results in patients with or without chemotherapy (0.01 < P < 0.001). Chemotherapy is thus one of the causes for the development of HLA antigen modifications in blood diseases and malignant tumours.

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Extraneous Lymphocytic Hl-a Antigens in Severe Combined Immunodeficiency Disease

Cited by 22 publications

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Enhanced representation of HL-A antigens on human lymphocytes after mitogenesis induced by phytohemagglutinin or Epstein-Barr virus.

Enhanced representation of HL-A antigens on human lymphocytes after mitogenesis induced by phytohemagglutinin or Epstein-Barr virus.

Specificity of Lymphocytotoxic Anti‐Human Antibodies in Normal Rabbit Sera

Chemotherapy—one of the Causes of Transient Loss of Hla Antigens and Lymphocyte Polyreactivity in Patients With Blood Diseases and Malignancies

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