Extremely low frequency electromagnetic field (ELF‐EMF) reduces oxidative stress and improves functional and psychological status in ischemic stroke patients

Abstract

As a result of ischaemia/reperfusion, massive generation of reactive oxygen species occurs, followed by decreased activity of antioxidant enzymes. Extremely low frequency electromagnetic fields (ELF-EMF) can modulate oxidative stress, but there are no clinical antioxidant studies in brain stroke patients. The aim of our study was to investigate the effect of ELF-EMF on clinical and antioxidant status in post-stroke patients. Fifty-seven patients were divided into two groups: ELF-EMF and non-ELF-EMF. Both groups underwent the same 4-week rehabilitation program. Additionally, the ELF-EMF group was exposed to an ELF-EMF field of 40 Hz, 7 mT for 15 min/day for 4 weeks (5 days a week). The activity of catalase and superoxide dismutase was measured in hemolysates, and total antioxidant status (TAS) determined in plasma. Functional status was assessed before and after the series of treatments using Activities of Daily Living (ADL), Mini-Mental State Examination (MMSE), and Geriatric Depression Scale (GDS). Applied ELF-EMF significantly increased enzymatic antioxidant activity; however, TAS levels did not change in either group. Results show that ELF-EMF induced a significant improvement in functional (ADL) and mental (MMSE, GDS) status. Clinical parameters had positive correlation with the level of enzymatic antioxidant protection. Bioelectromagnetics. 38:386-396, 2017. © 2017 Wiley Periodicals, Inc.

Extremely low frequency electromagnetic field reduces oxidative stress during the rehabilitation of post-acute stroke patients

“…Elevated SOD and CAT activities after surgery correlate with improved degrees of physical and mental disability based on the clinical scales used in research (the ADL, the MMSE, and the GDS). 37 A high level of oxidative stress is the cause of complications after stroke and, according to our research as well, it significantly affects the progress of the patient's rehabilitation process. 36,37 In our study, we determined the correlation between the level of markers of protein damage and the degree of clinical effects in patients rehabilitated by EMF.…”

“…37 A high level of oxidative stress is the cause of complications after stroke and, according to our research as well, it significantly affects the progress of the patient's rehabilitation process. 36,37 In our study, we determined the correlation between the level of markers of protein damage and the degree of clinical effects in patients rehabilitated by EMF. In order to define clinical effects, we used clinimetric scales: the ADL, the MMSE, and the GDS.…”

Pterostilbene administration improves the recovery potential of extremely low-frequency magnetic field in acute renal ischemia-reperfusion injury: An FTIR spectroscopic study

“…A pulsed magnetic field was observed to have a role in wound healing by increasing perfusion and vascularization (Pan et al, 2013) and by increasing endogenous fibroblast growth factor release (Callaghan et al, 2008). For the treatment of ischemic injury, the application of a pulsed and static magnetic field was documented to suppress the oxidative stress and thereby be a possible candidate for the treatment of myocardial (Ma et al, 2016), hindlimb (Pan et al, 2013), and ischemic injuries and the rehabilitation of stroke patients (Cichoń et al, 2017).…”

“…Recently, the use of a pulsed magnetic field was suggested to have a role in prevention or treatment of hindlimb (Pan et al, 2013) and myocardial (Ma et al, 2016) I/R injuries. In addition, the application of ELF-MF effectively improved the functional and physiological status of ischemic stroke patients (Cichoń et al, 2017).…”

The Levels of Functional-Vegetative Homeostasis as Criteria for Magnetotherapy Efficacy

“…Therefore, much attention should be paid to the recently discovered 'Functional-vegetative system of a human' (FvS) [12], which has proved the biophysical reality of traditional 'acupuncture channels' as well as their direct relation to the vegetative homeostasis and, in addition, requires defining of its place in the classical physiological system [13,14]. low-frequency magnetotherapy (MT) is widely used in modern physiotherapeutic practice using the magnetic component of lowfrequency electromagnetic fields [15][16][17]. Mt has an impressively wide range of indications (anti-inflammatory, anti-oedematous, trophic, hypocoagulant, vasoactive, anaesthetic, stimulating reparative processes and immuno-modelling) [18][19][20].…”