Fabrication and characterization of electrospun curcumin-loaded polycaprolactone-polyethylene glycol nanofibers for enhanced wound healing

Bui, Trung Hieu; Chung, Ok Hee; Cruz, Joseph dela; Park, Jun Seo

doi:10.1007/s13233-014-2179-6

Cited by 126 publications

(77 citation statements)

References 37 publications

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“…In this view, the use of biocompatible, absorbable polymers such as pectin (Ninan et al, 2014), chitin and its derivative chitosan (Muzzarelli, 2009), gelatin (Ulubayram et al, 2001), polycaprolactone (Bui et al, 2014), hyaluronic acid (Estes et al, 1993), and others have been described.…”

Section: Figure 1 Wound Classification (Kyriacos Et Al 2008)mentioning

confidence: 99%

Chitosan as a starting material for wound healing applications

Patrulea

Ostafe

Borchard

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

487

215

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Abstract:Chitosan and its derivatives have attracted great attention due to their properties beneficial for application to wound healing. The main focus of the present review is to summarize studies involving chitosan and its derivatives, especially N,N,N-trimethylchitosan (TMC), N,O-carboxymethyl-chitosan (CMC) and O-carboxymethyl-N,N,Ntrimethyl-chitosan (CMTMC), used to accelerate wound healing. Moreover, formulation strategies for chitosan and its derivatives, as well as their in vitro, in vivo and clinical applications in wound healing are described.

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Section: Figure 1 Wound Classification (Kyriacos Et Al 2008)mentioning

confidence: 99%

Chitosan as a starting material for wound healing applications

Patrulea

Ostafe

Borchard

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

487

215

View full text Add to dashboard Cite

show abstract

“…An alternative approach to bacterial adhesion resistance is to engineer nanofiber surfaces with hydrophilic modifiers such as poly(ethylene glycol), poly(vinyl alcohol), and zwitterionic molecules . Among these, zwitterions containing the pendant groups of phosphobetaine, sulfobetaine, and carboxybetaine have emerged as a promising class of materials for use in the new generation of bacterial anti‐adhesion surfaces, as their performance is comparable to and in some cases better than the other hydrophilic modifiers for resisting bacterial adhesion .…”

Section: Introductionmentioning

confidence: 99%

Engineering silver‐zwitterionic composite nanofiber membrane for bacterial fouling resistance

Ganesh

Kundukad

Cheng

et al. 2019

J of Applied Polymer Sci

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Bacterial attachment and fouling compromise material performance in applications ranging from marine equipment and biomedical devices to water treatment systems. For membrane‐based water treatment systems, bacterial attachment and biofilm formation decrease water purification efficiency and reduces mechanical durability of the membranes. In this work, we present a concurrent electrospinning and copolymerization approach to engineer composite nanofiber membranes comprising of silver nanoparticle containing poly(vinylidene fluoride‐co‐hexafluoropropylene) (PVDF‐HFP‐Ag) nanofibers and [copolymerized zwitterionic sulfobetaine methacrylate‐methacryl polyhedral oligomeric silsesquioxane]‐poly(methyl methacrylate) nanofibers. We characterized the surface morphology, topography, material chemistry, and wettability of the nanofiber membranes with scanning electron microscopy, atomic force microscopy, Fourier transform infrared spectroscopy, and contact angle measurements. We then challenged these nonwoven membranes with two model microbes, Gram‐negative Pseudomonas aeruginosa and Gram‐positive Staphylococcus aureus, and found that the silver‐zwitterionic composite nanofiber membrane exhibited superior bacterial fouling resistance by reducing >90% of bacterial attachment when compared to neat PVDF‐HFP and PVDF‐HFP‐Ag nanofiber membranes. This study demonstrates that concurrent electrospinning enables free‐standing nanofiber membranes with sustained bacterial fouling resistance, with potential in applications in filtration and water treatment technologies for which antifouling strategies are imperative. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47580.

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“…The biomolecule can be easily encapsulated in nanofibers by electrospinning the polymerbiomolecule blend without causing loss of the biomolecule as compared to nanoparticle, nanosphere mode of delivery 20 . It has been widely used in tissue engineering and wound dressing applications owing to its good mechanical properties, low immunogenicity, slow biodegradability, low toxicity, bioresorbability and high biocompatibility [20][21][22][23] . It has been widely used in tissue engineering and wound dressing applications owing to its good mechanical properties, low immunogenicity, slow biodegradability, low toxicity, bioresorbability and high biocompatibility [20][21][22][23] .…”

Section: Introductionmentioning

confidence: 99%

Fabrication of a triiodothyronine incorporated nanofibrous biomaterial: its implications on wound healing

Satish

Korrapati

2015

RSC Adv.

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With rising incidents of non-healing chronic wounds, functional restoration of the organs after a major wound insult is an essential requisite. The delivery of endogenous molecules through nanomaterials for supporting healing of such wounds has gained impetus in the past decade. Triiodothyronine (T 3 ) is a hormone that exerts its activity at various target organs and is reported to play a critical role in repair and regeneration of tissues after injury. The encapsulation of T 3 in nanofibers and its sustained release to enable wound healing has been attempted for the first time in this work. The physico-chemical characterization confirmed the encapsulation and uniform distribution of the hormone in the nanofiber. Functional characterization of the composite nanofibers revealed the significant positive influence of the T 3 -entrapped nanofibers on the proliferation and migration of skin cells. Thus this work reveals the effect of prolonged sustained delivery of T 3 from nanofibers which might promote the healing of chronic wounds.

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Fabrication and characterization of electrospun curcumin-loaded polycaprolactone-polyethylene glycol nanofibers for enhanced wound healing

Cited by 126 publications

References 37 publications

Chitosan as a starting material for wound healing applications

Chitosan as a starting material for wound healing applications

Engineering silver‐zwitterionic composite nanofiber membrane for bacterial fouling resistance

Fabrication of a triiodothyronine incorporated nanofibrous biomaterial: its implications on wound healing

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