Fabrication and evaluation of electrospun nanofibrous antimicrobial nylon 6 membranes

Tan, Kuitian; Obendorf, S. Kay

doi:10.1016/j.memsci.2007.08.015

Cited by 115 publications

(73 citation statements)

References 30 publications

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“…These N-halamine precursors have respectively different number of amide, imide and amine groups. It is reported that the antibacterial power of N-halamine is in an order of imide > amide > amine halamine [19]. To improve the antibacterial activity, developing the N-halamine precursor with more imide groups in structure is axiomatic.…”

Section: Introductionmentioning

confidence: 99%

Bactericidal evaluation of N-halamine-functionalized silica nanoparticles based on barbituric acid

Dong

Xue

Lan

et al. 2014

Colloids and Surfaces B: Biointerfaces

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Section: Introductionmentioning

confidence: 99%

Bactericidal evaluation of N-halamine-functionalized silica nanoparticles based on barbituric acid

Dong

Xue

Lan

et al. 2014

Colloids and Surfaces B: Biointerfaces

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“…26 Electrospun fiber mats carrying various antimicrobial agents, carbon nanotubes, N-halamines, vitamin A, and vitamin E have been reported. [27][28][29][30][31][32] However, the in vitro efficacy of antifungal drugs incorporated into electrospun fibers against yeasts/filamentous fungi has not yet been demonstrated. 33 In terms of mechanism of action, the available antifungals can be grouped into three categories: 1) polyene, azole, and allylamine antifungals that target ergosterol or ergosterol biosynthetic pathways; 2) echinocandins, which are β-glucan synthase inhibitors; and 3) fluoropyrimidines, which target RNA synthesis.…”

Section: Introductionmentioning

confidence: 99%

Interaction of gelatin with polyenes modulates antifungal activity and biocompatibility of electrospun fiber mats

Lakshminarayanan

Sridhar

Loh

et al. 2014

IJN

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Topical application of antifungals does not have predictable or well-controlled release characteristics and requires reapplication to achieve therapeutic local concentration in a reasonable time period. In this article, the efficacy of five different US Food and Drug Administration-approved antifungal-loaded (amphotericin B, natamycin, terbinafine, fluconazole, and itraconazole) electrospun gelatin fiber mats were compared. Morphological studies show that incorporation of polyenes resulted in a two-fold increase in fiber diameter and the mats inhibit the growth of yeasts and filamentous fungal pathogens. Terbinafine-loaded mats were effective against three filamentous fungal species. Among the two azole antifungals compared, the itraconazole-loaded mat was potent against Aspergillus strains. However, activity loss was observed for fluconazole-loaded mats against all of the test organisms. The polyene-loaded mats displayed rapid candidacidal activities as well. Biophysical and rheological measurements indicate strong interactions between polyene antifungals and gelatin matrix. As a result, the polyenes stabilized the triple helical conformation of gelatin and the presence of gelatin decreased the hemolytic activity of polyenes. The polyene-loaded fiber mats were noncytotoxic to primary human corneal and sclera fibroblasts. The reduction of toxicity with complete retention of activity of the polyene antifungal-loaded gelatin fiber mats can provide new opportunities in the management of superficial skin infections.

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“…The microbead/nanofiber structure might be caused by the low concentration of PLLA (8% w/v). [46,47] When PNIPAAm was added into PLLA, the number and size of the microbeads were reduced. The average bead sizes of PNIPAAm/PLLA films with 5, 10, 15, and 20 wt.-% PNIPAAm were 4.50, 4.43, 4.14, and 3.51 mm, respectively.…”

Section: Resultsmentioning

confidence: 99%

Switchable Wettability of Thermo‐Responsive Biocompatible Nanofibrous Films Created by Electrospinning

Wang

et al. 2010

Macro Materials & Eng

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Thermo‐responsive PNIPAAm/PLLA nanofibrous films with tunable surface morphologies and better biocompatibility were prepared by electrospinning technique. The electrospun composite films possessed a “bead‐on‐string” structure. The wettability of nanofibrous films was observed by water CA measurements. The results showed that the electrospinning process and addition of PLLA did not change the thermo‐sensitivity of PNIPAAm. The wettability of electrospun PNIPAAm/PLLA composite films could switch from superhydrophilic to superhydrophobic when the temperature increased from 20 to 50 °C. Electrospinning is a promising way to create stimuli‐responsive surfaces with potential application in the design and tactics of controllable drug delivery system.

show abstract

Fabrication and evaluation of electrospun nanofibrous antimicrobial nylon 6 membranes

Cited by 115 publications

References 30 publications

Bactericidal evaluation of N-halamine-functionalized silica nanoparticles based on barbituric acid

Bactericidal evaluation of N-halamine-functionalized silica nanoparticles based on barbituric acid

Interaction of gelatin with polyenes modulates antifungal activity and biocompatibility of electrospun fiber mats

Switchable Wettability of Thermo‐Responsive Biocompatible Nanofibrous Films Created by Electrospinning

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