Fabrication and Physico-Chemical Properties of Antifungal Samarium Doped Hydroxyapatite Thin Films

Ciobanu, Carmen Steluţa; Predoi, Daniela; Chapon, Patrick; Predoi, Mihai Valentin; Iconaru, Simona Liliana

doi:10.3390/coatings11121466

Cited by 9 publications

(2 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The antifungal assays also suggested that the 5EuHAp suspensions exhibited better antifungal activity compared to 5EuHAp coatings. These results are also in good agreement with previously reported studies regarding coatings that almost completely retain the antifungal effects of the suspensions used for their depositions [40,49]. The preliminary results obtained from the in vitro antifungal assays highlighted that both 5EuHAp suspensions and coatings present strong antifungal properties that are correlated with the incubation time.…”

Section: Resultssupporting

confidence: 91%

Physicochemical Characterization of Europium-Doped Hydroxyapatite Thin Films with Antifungal Activity

et al. 2022

Self Cite

View full text Add to dashboard Cite

Owing to its unique biological and physicochemical properties, hydroxyapatite (HAp) represents one of the most extensively studied biomaterials for biomedical applications. It is well known that Candida is currently one of the fungi frequently involved in the onset and development of post-implant infections and, owing to the appearance of antifungal resistance, it is quite difficult to treat despite all the tremendous efforts made in this regard by the scientific world. Therefore, in this context, we report for the first time in this paper, the development and characterization of europium-doped thin films (5EuHAp, xEu = 0.05) on a Si substrate by a spin-coating method. The results of ultrasound (US), zeta (ζ) potential, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), scanning electron microscopy (SEM), and Fourier-transform infrared spectroscopy (FTIR) studies are presented. The XRD studies conducted on 5EuHAp suspension revealed the nanometric dimensions of the particles and sample purity. In addition, a moderate stability of the 5EuHAp suspension was observed. XPS measurements revealed the presence of Eu 3d in the 5EuHAp thin films. In the SEM micrographs, the surface uniformity and the absence of the surface defects could be observed. Moreover, the results of the FTIR studies showed the presence of the vibrational bands specific to the HAp structure in the studied sample. The antifungal activity of the HAp and 5EuHAp suspensions and coatings was evaluated using the Candida albicans ATCC 10231 (C. albicans) fungal strain. The qualitative assays of the antifungal properties of HAp and 5EuHAp coatings were also visualized by SEM and CLSM. The antifungal studies revealed that both 5EuHAp suspensions and coatings exhibited noticeable antifungal activity against C. albicans cells.

show abstract

Section: Resultssupporting

confidence: 91%

Physicochemical Characterization of Europium-Doped Hydroxyapatite Thin Films with Antifungal Activity

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…The antifungal activity was also obtained with the 0.05Sm-HAp NPs in suspension and not only with the coatings [ 112 ]. In fact, increasing the molar concentration of Sm up to 0.5 preserved antifungal activity against C. albicans when the coating was prepared and as a NPs suspension [ 113 ].…”

Section: Biological Role Of Hap and Its Substitution Ionsmentioning

confidence: 99%

Lanthanides-Substituted Hydroxyapatite for Biomedical Applications

Lama-Odría

Valle

Puiggalı́

2023

IJMS

View full text Add to dashboard Cite

Lately, there has been an increasing demand for materials that could improve tissue regenerative therapies and provide antimicrobial effects. Similarly, there is a growing need to develop or modify biomaterials for the diagnosis and treatment of different pathologies. In this scenario, hydroxyapatite (HAp) appears as a bioceramic with extended functionalities. Nevertheless, there are certain disadvantages related to the mechanical properties and lack of antimicrobial capacity. To circumvent them, the doping of HAp with a variety of cationic ions is emerging as a good alterative due to the different biological roles of each ion. Among many elements, lanthanides are understudied despite their great potential in the biomedical field. For this reason, the present review focuses on the biological benefits of lanthanides and how their incorporation into HAp can alter its morphology and physical properties. A comprehensive section of the applications of lanthanides-substituted HAp nanoparticles (HAp NPs) is presented to unveil the potential biomedical uses of these systems. Finally, the need to study the tolerable and non-toxic percentages of substitution with these elements is highlighted.

show abstract

Analysing the impact of Dy dopants on Zn-based hydroxyapatites: modelling and characterization perspectives

BÜYÜK,

BULUT,

TEMUZ

et al. 2024

Bull Mater Sci

View full text Add to dashboard Cite

Fabrication and Physico-Chemical Properties of Antifungal Samarium Doped Hydroxyapatite Thin Films

Cited by 9 publications

References 59 publications

Physicochemical Characterization of Europium-Doped Hydroxyapatite Thin Films with Antifungal Activity

Physicochemical Characterization of Europium-Doped Hydroxyapatite Thin Films with Antifungal Activity

Lanthanides-Substituted Hydroxyapatite for Biomedical Applications

Analysing the impact of Dy dopants on Zn-based hydroxyapatites: modelling and characterization perspectives

Contact Info

Product

Resources

About