Fabrication of a magnesium alloy with excellent ductility for biodegradable clips

Ikeo, Naoko; Nakamura, Ryota; Naka, Kosuke; Hashimoto, Toshiaki; Yoshida, Toshihiko; Urade, Takeshi; Fukui, Kenji; Yabuuchi, Hidetake; Fukumoto, Takumi; Ku, Yonson; Mukai, Toshiji

doi:10.1016/j.actbio.2015.10.023

Cited by 42 publications

(27 citation statements)

References 36 publications

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“…Various metallic materials, including stainless steels, cobalt alloys, magnesium alloys, titanium alloys and commercially pure (CP) titanium, have been previously investigated as biomaterials [1][2][3][4][5][6][7] for the replacement of bone tissue. CP titanium is of particular interest in this regard since it exhibits good biocompatibility and high corrosion resistance, and does not contain toxic elements such as Cr, Al or V. However, this material has lower tensile strength and fatigue strength than titanium alloys [1][2][3][4], and so improving the mechanical properties of CP titanium has become an important topic.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of near-threshold fatigue crack propagation in harmonic-structured CP titanium with a bimodal grain size distribution

Kikuchi

Mori

Kubozono

et al. 2017

Engineering Fracture Mechanics

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To examine near-threshold fatigue crack propagation in commercially pure (CP) titanium with a bimodal harmonic structure, which is defined as a coarse grained structure surrounded by a network of fine grains, K-decreasing tests were conducted. The crack growth rates for harmonic-structured CP titanium were higher than those for homogeneous material with coarse grains at comparable stress intensity range, while the threshold stress intensity range was lower. This phenomenon was attributed to a reduction in the extent of crack closure and the effective threshold stress intensity range, resulting from the presence of fine grains in the harmonic structure.

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Section: Introductionmentioning

confidence: 99%

Evaluation of near-threshold fatigue crack propagation in harmonic-structured CP titanium with a bimodal grain size distribution

Kikuchi

Mori

Kubozono

et al. 2017

Engineering Fracture Mechanics

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“…This is primarily due to their attractive properties such as biocompatibility, low density, high specific strength and the ability to degrade and safely be absorbed under physiological conditions123, as well as can be better visualized in CT scans4. Unfortunately, the initial high degradation rate is accompanied by hydrogen evolution and solution alkalization which can delay the healing and cause implant loosening5.…”

mentioning

confidence: 99%

Stimulatory effects of the degradation products from Mg-Ca-Sr alloy on the osteogenesis through regulating ERK signaling pathway

et al. 2016

Sci Rep

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The influence of Mg-1Ca-xwt.% Sr (x = 0.2, 0.5, 1.0, 2.0) alloys on the osteogenic differentiation and mineralization of pre-osteoblast MC3T3-E1 were studied through typical differentiation markers, such as intracellular alkaline phosphatase (ALP) activity, extracellular collagen secretion and calcium nodule formation. It was shown that Mg-1Ca alloys with different content of Sr promoted cell viability and enhanced the differentiation and mineralization levels of osteoblasts, and Mg-1Ca-2.0Sr alloy had the most remarkable and significant effect among all. To further investigate the underlying mechanisms, RT-PCR and Western Blotting assays were taken to analyze the mRNA expression level of osteogenesis-related genes and intracellular signaling pathways involved in osteogenesis, respectively. RT-PCR results showed that Mg-1Ca-2.0Sr alloy significantly up-regulated the expressions of the transcription factors of Runt-related transcription factor 2 (RUNX2) and Osterix (OSX), Integrin subunits, as well as alkaline phosphatase (ALP), Bone sialoprotein (BSP), Collagen I (COL I), Osteocalcin (OCN) and Osteopontin (OPN). Western Blotting results suggested that Mg-1Ca-2.0Sr alloy rapidly induced extracellular signal-regulated kinase (ERK) activation but showed no obvious effects on c-Jun N terminal kinase (JNK) and p38 kinase of MAPK. Taken together, our results demonstrated that Mg-1Ca-2.0Sr alloy had excellent biocompatibility and osteogenesis via the ERK pathway and is expected to be promising as orthopedic implants and bone repair materials.

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“…いものには，Ca などを添加したマグネシウム合金 8) , [14][15][16] や，マグネシウムにリン酸カルシウムを分散／被覆させた材料 11,17) がある．リン酸カルシウムを分散させた複合材料の場合，分散物の体積率などを変化させることによって生体内分解速度が調整できると予想される Fig. 5 Variation of loss factor with strain amplitude in Mg-1Ca-10 vol％HAp composite, pure magnesium processed by powder metallurgy route 23) and Mg-10 vol％HAp composite 23) .…”

Section: リン酸カルシウムの一種である水酸アパタイト (以下，Hapunclassified

Hydroxyapatite Dispersed Magnesium-Based Composite Produced from Pulverized Magnesium Alloy Powder and Its Mechanical Properties

Watanabe

Motoyama

Ikeo

et al. 2018

J. Japan Inst. Metals and Materials

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A magnesium matrix composite made of Mg-1mass％Ca and 10 vol％ hydroxyapatite (HAp) particles was synthesized. The alloy powder was processed by pulverization of the small blocks of the alloy ingot using a high-speed blade grinder. Unreacted composite was successfully produced by extruding the two component powders at a temperature of 538 K. In the extruded composites, the grains of the magnesium matrix were equiaxed and the matrix grain size was 3.9 µm. As for the HAp particles, both thin clustering and severe agglomeration with the size of ~30 µm were observed. The Young＇s modulus, tensile yield strength and tensile strength of the extruded composite were 39 GPa, 101 MPa and 153 MPa, respectively. The damping capacity of the composite was higher than that of extruded magnesium. The composite also showed good forgeability at a temperature of 523 K. However, quite high impurity contents of Fe (0.130 mass％) and Ni (0.010 mass％) were introduced in the magnesium matrix of the composite, probably as a result of contamination that accumulates during the processing (pulverization) of the alloy powder.

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Fabrication of a magnesium alloy with excellent ductility for biodegradable clips

Cited by 42 publications

References 36 publications

Evaluation of near-threshold fatigue crack propagation in harmonic-structured CP titanium with a bimodal grain size distribution

Evaluation of near-threshold fatigue crack propagation in harmonic-structured CP titanium with a bimodal grain size distribution

Stimulatory effects of the degradation products from Mg-Ca-Sr alloy on the osteogenesis through regulating ERK signaling pathway

Hydroxyapatite Dispersed Magnesium-Based Composite Produced from Pulverized Magnesium Alloy Powder and Its Mechanical Properties

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