Fabrication of Biodegradable Nanofibers of Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) via Electrospinning

Abstract

For the first time, poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) nanofibrous membrane has been fabricated via electrospinning method. To improve the electrospinnability and reduce the diameter of fibers, the solvent and salt additives were used that affected on the parameters including such as the viscosity and the conductivity of the electrospinning solution for poly(3-hydroxybutyrate-co-3-hydroxyhexanoate). Since the additional salts should be removed, it could be inferred that the co-solvent system was predominant to prepare the nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) membrane. This biodegradable nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) membrane has a great potential to be used in the various application fields such as tissue engineering, implants, packaging materials, agriculture, and so on.

Fabrication of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) Fibers Using Centrifugal Fiber Spinning: Structure, Properties and Application Potential

“…A polymer concentration of 10 wt.% seems effective to form continuous PHBHHx fibers with CFS (under the processing conditions used in the study). These trends correlate well with those of electrospun PHBHHx fibers, where bead-free and continuous fibers with increased diameters in a similar concentration range of 8-12 wt.% (chloroform solvent) were observed (PHBHHx M w = 4.5 × 10 5 g/mol) [25].…”

“…A variety of synthetic and natural polymers have been electrospun into fibers [17]. In addition, electrospun fibers fabricated from PHAs [18] such as PHB [19], PHBV [20][21][22][23], PHBHHx [24][25][26][27][28][29][30], poly(3hydroxybutyrate-co-4-hydroxybutyrate) (P3HB4HB) [31] and blends thereof [32] have been reported in the literature. After the spinning process, fibers can undergo several thermal posttreatments, including annealing and heat pressing, to produce transparent or translucent films or multilayer structures with excellent mechanical, barrier, and optical properties for food packaging applications [33].…”

Hybrid Systems Biomolecule-Polymeric Nanoparticle: Synthesis, Properties and Biotechnological Applications

“…Electrospun nanofiber matrices show morphological similarities to the natural extra-cellular matrix (ECM), characterized by ultrafine continuous fibers, high surface-to-volume ratio, high porosity and variable pore-size distribution. Efforts have been made to modify nanofiber surfaces with several bioactive molecules to provide cells with the necessary chemical cues and a more in vivo like environment [237][238][239].…”