Fabrication of curcumin-loaded bovine serum albumin (BSA)-dextran nanoparticles and the cellular antioxidant activity

Fan, Yuting; Jiang, Yi; Zhang, Yuzhu; Yokoyama, Wallace

doi:10.1016/j.foodchem.2017.07.075

Cited by 156 publications

(61 citation statements)

References 38 publications

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“…Fan et al . () produced nanoparticles loaded with curcumin into a protein‐based matrix. The authors reported high EE (73·5%) with internalized curcumin values similar to those shown here, despite the difference in capsule size (115 nm).…”

Section: Resultsmentioning

confidence: 99%

“…Despite the relatively higher EE, the nanometric structure of the liposomes led to a low content of curcumin incorporated into the capsules, in the order of nanograms, which highlights the favourable morphological characteristics of the yeast cells as encapsulating agents. Fan et al (2018) produced nanoparticles loaded with curcumin into a protein-based matrix. The authors reported high EE (73Á5%) with internalized curcumin values similar to those shown here, despite the difference in capsule size (115 nm).…”

Section: Increase Of Curcumin Encapsulation Into S Cerevisiae Cellsmentioning

confidence: 99%

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Curcumin and fisetin internalization into Saccharomyces cerevisiae cells via osmoporation: impact of multiple osmotic treatments on the process efficiency

Medeiros

Correia

Dupont

et al. 2018

Lett Appl Microbiol

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For the first time in the literature, a protocol of serial osmoporation stages to enhance the encapsulation efficiency of hydrophobic low molecular weight molecules (curcumin and fisetin) into Saccharomyces cerevisiae cells was determined. By increasing overall efficiency, this protocol empowers the encapsulation process and creates a rational way to reduce waste for future industrial osmoporation applications.

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Section: Resultsmentioning

confidence: 99%

Section: Increase Of Curcumin Encapsulation Into S Cerevisiae Cellsmentioning

confidence: 99%

Curcumin and fisetin internalization into Saccharomyces cerevisiae cells via osmoporation: impact of multiple osmotic treatments on the process efficiency

Medeiros

Correia

Dupont

et al. 2018

Lett Appl Microbiol

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show abstract

“…During the last few decades, inorganic nanoparticles have been successfully evaluated for their antioxidant properties, and most recently nanoantioxidants have shown the capability of attenuating oxidative stress with greater sensitivity, cellular antioxidant activity, least cytotoxic effects, and targeted delivery. In this context, covalent attachment or encapsulation of antioxidants with nanospheres of different origins, such as inorganic nanoparticles, metal nanoparticles, natural polymer-based nanoparticles, liposomes, protein-polysaccharide-based nanoparticles, and many more combinations have been tested, and are under consideration for various applications [31,140]. However, to obtain the highest benefits in terms of catalytic and biological activity from the nanoantioxidant composites, the nature, physicochemical properties, as well as mechanism of actions need to be well understood.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Nanoantioxidants: Recent Trends in Antioxidant Delivery Applications

et al. 2019

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Antioxidants interact with free radicals, terminating the adverse chain reactions and converting them to harmless products. Antioxidants thus minimize the oxidative stress and play a crucial role in the treatment of free radicals-induced diseases. However, the effectiveness of natural and/or synthetic antioxidants is limited due to their poor absorption, difficulties to cross the cell membranes, and degradation during delivery, hence contributing to their limited bioavailability. To address these issues, antioxidants covalently linked with nanoparticles, entrapped in nanogel, hollow particles, or encapsulated into nanoparticles of diverse origin have been used to provide better stability, gradual and sustained release, biocompatibility, and targeted delivery of the antioxidants with superior antioxidant profiles. This review aims to critically evaluate the recent scientific evaluations of nanoparticles as the antioxidant delivery vehicles, as well as their contribution in efficient and enhanced antioxidant activities.

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“…It has been found that CUR derivatives inhibit the accumulation of heavy metals in AD [152]. A study conducted by Fan et al [153] analyzed the role of different antioxidants in foods, including CUR, in AD. The result showed that due to its chelating action, CUR prevents the accumulation of heavy metals in the brain.…”

Section: Antioxidant Mechanism Of Curcumin In Alzheimer'smentioning

confidence: 99%

Curcumin’s Nanomedicine Formulations for Therapeutic Application in Neurological Diseases

Salehi

Calina

Docea

et al. 2020

JCM

139

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The brain is the body’s control center, so when a disease affects it, the outcomes are devastating. Alzheimer’s and Parkinson’s disease, and multiple sclerosis are brain diseases that cause a large number of human deaths worldwide. Curcumin has demonstrated beneficial effects on brain health through several mechanisms such as antioxidant, amyloid β-binding, anti-inflammatory, tau inhibition, metal chelation, neurogenesis activity, and synaptogenesis promotion. The therapeutic limitation of curcumin is its bioavailability, and to address this problem, new nanoformulations are being developed. The present review aims to summarize the general bioactivity of curcumin in neurological disorders, how functional molecules are extracted, and the different types of nanoformulations available.

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Fabrication of curcumin-loaded bovine serum albumin (BSA)-dextran nanoparticles and the cellular antioxidant activity

Cited by 156 publications

References 38 publications

Curcumin and fisetin internalization into Saccharomyces cerevisiae cells via osmoporation: impact of multiple osmotic treatments on the process efficiency

Curcumin and fisetin internalization into Saccharomyces cerevisiae cells via osmoporation: impact of multiple osmotic treatments on the process efficiency

Nanoantioxidants: Recent Trends in Antioxidant Delivery Applications

Curcumin’s Nanomedicine Formulations for Therapeutic Application in Neurological Diseases

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