Fabrication of gelatin-based and Zn2+-incorporated composite hydrogel for accelerated infected wound healing

Multifunctional silicon calcium phosphate composite scaffolds promote stem cell recruitment and bone regeneration

“…As shown in Fig. 5B, the CCK-8 assay 42 confirmed that the absorbance values of all groups increased after 1, 4, and 7 days, indicating that MSCs could proliferate continuously on all scaffolds, and all of samples showed no obvious cytotoxicity. The cell viability of the SiCP group was slightly higher than the SF group at day 1, 4, and 7.…”

Scaffolds in the microbial resistant era: Fabrication, materials, properties and tissue engineering applications

“…Even though zinc-based material scaffolds have been studied much less than silver-based ones, these alternative approaches with zinc are very promising for skin tissue engineering applications. For example, gelatin-based and Zn 2+ -incorporated composite hydrogels have been developed for accelerated infected wound healing [ 292 ]. This hydrogel exhibited sustainable release behavior of Zn 2+ with good biocompatibility toward NIH-3T3 cells and strong antibacterial abilities against E. coli and S. aureus.…”

“…The potential antibacterial mechanism of Zn-embedded biomaterials is also mainly related to the production of ROS [ 428 ]. For example, the antibacterial mechanism of a gelatin-based and Zn 2+ -incorporated composite hydrogel (Gel@Zn) for rapid infected wound healing consisted of reducing the ATP level, generating ROS and leakage of protein [ 292 ] ( Fig. 18 (b)).…”

Aggressive strategies for regenerating intervertebral discs: stimulus-responsive composite hydrogels from single to multiscale delivery systems

“…Currently, stimulus-responsive composite hydrogels have been widely used in wound healing, drug delivery, cancer targeting, immunotherapy, and tissue engineering and are expected to be applied in IVD tissue engineering therapeutic strategies. [19][20][21][22] Next, we discuss the specific response mechanisms and preparation processes currently used to prepare stimulus-responsive composite hydrogel biomaterials and their effects on IVD regeneration.…”