Fabrication of gelatin–siloxane fibrous mats via sol–gel and electrospinning procedure and its application for bone tissue engineering

Ren, Lei; Wang, Jūn; Yang, Fangyu; Wang, Lin; Wang, Dong; Wang, Tianxiao; Tian, Miaomiao

doi:10.1016/j.msec.2009.12.013

Cited by 36 publications

(13 citation statements)

References 44 publications

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“…10 These organic/inorganic hybrids can be prepared by mixing a polymer solution and an inorganic sol, followed by hydrolysis and condensation. 11 In addition, several manufacturing methods have been developed to produce porous hybrid scaffolds directly from polymer/inorganic sol mixtures, [12][13][14][15] for example, porous gelatin-siloxane scaffolds that demonstrated great potential for tissue regeneration. However, it is still a challenge to explore new ways of tightly controlling the porous structure of porous hybrid scaffolds for improved mechanical properties and biological functions in vitro and in vivo.…”

Section: Introductionmentioning

confidence: 99%

Porous gelatin–siloxane hybrid scaffolds with biomimetic structure and properties for bone tissue regeneration

et al. 2014

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We produced highly porous gelatin-siloxane (GLA-S) hybrid scaffolds with biomimetic anisotropic porous structure, physiochemical properties, mechanical behaviors and biological functions by treating gelatin-siloxane hybrid gels in an ammonium hydroxide solution. The siloxane used as an inorganic phase could effectively crosslink the gelatin polymer, which allowed for the unidirectional enlargement of ammonia vacuoles during ammonium hydroxide treatment. This created aligned pores in an axial direction when the siloxane contents (10 and 20 wt %) were high. In addition, the gelatin polymer could be uniformly hybridized with the siloxane phase at the molecular level, while intense interaction between these two phases could be achieved. This resulted in a significant increase in mechanical properties. The GLA-S hybrid scaffold with a siloxane content of 10 wt % showed reasonably high compressive yield strength of 4.2 ± 0.1 MPa and compressive modulus of 84 ± 5 MPa at a porosity of 86 vol %, which would be comparable to those of natural cancellous bone. In addition, the GLA-S hybrid scaffold had good biocompatibility assessed by in vitro cell tests using pre-osteoblast MC3T3-E1 cells.

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Section: Introductionmentioning

confidence: 99%

Porous gelatin–siloxane hybrid scaffolds with biomimetic structure and properties for bone tissue regeneration

et al. 2014

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“…Ren et al used gelatin and silicone to prepare composite nanofiber scaffolds as bone repairing material incorporating Ca 2+ ions. Their results indicated that these composite materials could promote accumulation of bone apatite and the differentiation and proliferation of osteoblasts [99] (Figure 5). Li et al used electrospinning to prepare composite nanofiber scaffolds from polyaniline and gelatin, whose properties were dependent on the amount of polyaniline present.…”

Section: Lee Et Al Utilized Electrospinning Techniques To Prepare Pcmentioning

confidence: 99%

Electrospinning of Collagen and Its Derivatives for Biomedical Applications

Lü¹,

Guo²

2018

Novel Aspects of Nanofibers

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Collagen, gelatin and their derived polypeptides can act as multifunctional natural polymers with excellent physicochemical properties for biomedical applications. The use of electrospinning technology can convert collagen materials into nanofibrous materials that exhibit porous micro-nanostructures with good mechanical properties and excellent biocompatibility profiles. In this chapter, a systematic review of collagen electrospinning is presented and related applications are introduced including tissue engineering (e.g., artificial skin, artificial vasculature, cartilage repair, etc.), drug delivery, hemostatic dressings, periodontal restoration, biofilms, and wound dressings will now be discussed.

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“…In addition to lignin, gelatin has also found use in forming copolymers with siloxanes. This area has mostly focused on developing scaffolds for applications as a biomimetic/bioactive in bone tissue engineering (Ren et al 2001(Ren et al , 2010Xue et al 2014). Gelatin itself is a good scaffold material for tissue growth; however, its lack of bioactivity vs. Si-OH groups limits bone development.…”

Section: Lignin and Gelatin Based Siloxane Copolymersmentioning

confidence: 99%

Green routes to silicon-based materials and their environmental implications

Furgal

Lenora

2019

Physical Sciences Reviews

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Abstract The “greening” of silicon chemistry is fundamentally important for the future of the field. Traditional methods used to make silicon-based materials rely on carbon rich processes that are highly energy intensive, cause pollution, and are unsustainable. Researchers have taken up the challenge of developing new chemistries to circumvent the difficulties associated with traditional silicon material synthesis. Most of this work has been in the conversion of the “green” carbon neutral biogenic silica source rice hull ash (RHA, ~85 % silica) into useful silicon building blocks such as silica’s, silicon, and alkoxysilanes by using the inherently higher surface area and reactivity of RHA to sidestep the low reactivity of mined silica sources. This is a review of the work that has been done in the area of developing more environmentally benign methods for the synthesis and use of silicon containing materials to eliminate the negative impact on the environment.

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Fabrication of gelatin–siloxane fibrous mats via sol–gel and electrospinning procedure and its application for bone tissue engineering

Cited by 36 publications

References 44 publications

Porous gelatin–siloxane hybrid scaffolds with biomimetic structure and properties for bone tissue regeneration

Porous gelatin–siloxane hybrid scaffolds with biomimetic structure and properties for bone tissue regeneration

Electrospinning of Collagen and Its Derivatives for Biomedical Applications

Green routes to silicon-based materials and their environmental implications

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