Fabrication of Hybrid Hydrogels from Silk Fibroin and Tannic Acid with Enhanced Gelation and Antibacterial Activities

Jiang, Juan; Liang, Shufeng; Yan, Yufei; Tian, Xin; Li, Xinming

doi:10.1021/acsbiomaterials.9b00604

Cited by 126 publications

(98 citation statements)

References 55 publications

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“…For example, the injectable, biodegradable and biocompatible hydrogels, which can respond to both pH and physiological temperature, are more suitable for the tumor treatment by the targeted drug release 110 . The hydrogels with optimal mechanical strength, injectability, antibacterial activity and adhesion are the ideal choice for wound healing and skin infection treatment 81 .…”

Section: Discussionmentioning

confidence: 99%

“…In addition to the use of growth factors, cytokines and drugs to biologically functionalize the SF hydrogels 5 , the development of the hydrogels with specific adhesion with the wound is also an effective method to improve the functionality of the SF-based wound dressings 112 . In a related study, Juan Jing et al 81 reported a SF hydrogel with adhesive properties. The hydrogel possessed both antibacterial and antioxidant activity.…”

Section: Wound Healingmentioning

confidence: 96%

“…Tannic acid (TA) is also rich in catechol and pyrogallol groups. LinJuan Jing et al 81 mixed SF and TA and observed that the introduction of TA effectively induced the gelation of SF. The adhesion performance of the SF/TA hydrogel was tested by the lap shear test.…”

Section: Adhesionmentioning

confidence: 99%

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Functional silk fibroin hydrogels: preparation, properties and applications

2021

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Section: Discussionmentioning

confidence: 99%

Section: Wound Healingmentioning

confidence: 96%

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Functional silk fibroin hydrogels: preparation, properties and applications

2021

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“…Tannic acid was used to form a complex with silk by non-covalent interactions. Gel-like forms based on silk fibroin cross-linked by tannic acid showed improved wet-adhesive properties and stability [ 71 , 72 ]. TA and silk sericin may be conjugated via hydrogen bonding interactions.…”

Section: Tannic Acid-based Biomaterialsmentioning

confidence: 99%

Tannic Acid with Antiviral and Antibacterial Activity as A Promising Component of Biomaterials—A Minireview

2020

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As a phenolic acid, tannic acid can be classified into a polyphenolic group. It has been widely studied in the biomedical field of science because it presents unique antiviral as well as antibacterial properties. Tannic acid has been reported to present the activity against Influeneza A virus, Papilloma viruses, noroviruses, Herpes simplex virus type 1 and 2, and human immunodeficiency virus (HIV) as well as activity against both Gram-positive and Gram-negative bacteria as Staphylococcus aureus, Escherichia coli, Streptococcus pyogenes, Enterococcus faecalis, Pseudomonas aeruginosa, Yersinia enterocolitica, Listeria innocua. Nowadays, compounds of natural origin constitute fundaments of material science, and the trend is called “from nature to nature”. Although biopolymers have found a broad range of applications in biomedical sciences, they do not present anti-microbial activity, and their physicochemical properties are rather poor. Biopolymers, however, may be modified with organic and inorganic additives which enhance their properties. Tannic acid, like phenolic acid, is classified into a polyphenolic group and can be isolated from natural sources, e.g., a pure compound or a component of a plant extract. Numerous studies have been carried out over the application of tannic acid as an additive to biopolymer materials due to its unique properties. On the one hand, it shows antimicrobial and antiviral activity, while on the other hand, it reveals promising biological properties, i.e., enhances the cell proliferation, tissue regeneration and wound healing processes. Tannic acid is added to different biopolymers, collagen and polysaccharides as chitosan, agarose and starch. Its activity has been proven by the determination of physicochemical properties, as well as the performance of in vitro and in vivo studies. This systematics review is a summary of current studies on tannic acid properties. It presents tannic acid as an excellent natural compound which can be used to eliminate pathogenic factors as well as a revision of current studies on tannic acid composed with biopolymers and active properties of the resulting complexes.

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“…Jing et al . [ 13 ] reported a (Tannins Acid) TA gelatin-enhanced SF–TA hybrid hydrogel based on a chemical crosslinking method which exhibited remarkable antimicrobial and antioxidant activities for improving wound healing.…”

Section: Introductionmentioning

confidence: 99%

Photocrosslinking silver nanoparticles–aloe vera–silk fibroin composite hydrogel for treatment of full-thickness cutaneous wounds

Liu

Fan

et al. 2021

Regenerative Biomaterials

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Damage to the skin causes physiological and functional issues. The most effective treatment approach is the use of wound dressings. Silk fibroin (SF) is a promising candidate biomaterial for regulating wound healing; however, its antibacterial properties and biological activity must be further improved. In this study, a photocrosslinking hydrogel was developed to treat full-thickness cutaneous wounds. The composite hydrogel (Ag-AV-SF-hydrogel) was prepared by introducing the silver nanoparticles (AgNPs) and aloe vera (AV) as the modifiers. In vitro study, it exhibited great antibacterial ability, biocompatibility, and cell-proliferation and -migration-promoting capacities. It also showed the pH-response releasing properties which release more AgNPs in a simulated chronic infection environment. The healing effect evaluation in vivo showed the healing-promoting ability of the Ag-AV-SF-hydrogel was stronger than the single-modifiers groups, and the healing rate of the it reached 97.02% on day 21, higher than the commercial wound dressing, silver sulfadiazine cream (SS) on sale. Additionally, the histological and protein expression results showed that the Ag-AV-SF-hydrogel has a greater effect on the pro-healing regenerative phenotype with M2 macrophages at the early stage, reconstructing the blood vessels networks and inhibiting the formation of scars. In summary, the Ag-AV-SF-hydrogel developed in this study had good physical properties, overwhelming antibacterial properties, satisfactory biocompatibility and significantly promoting effect on cell proliferation, migration and wound healing. Overall, our results suggest that the Ag-AV-SF-hydrogel we developed has great potential for improving the wound healing in clinical treatment.

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Fabrication of Hybrid Hydrogels from Silk Fibroin and Tannic Acid with Enhanced Gelation and Antibacterial Activities

Cited by 126 publications

References 55 publications

Functional silk fibroin hydrogels: preparation, properties and applications

Functional silk fibroin hydrogels: preparation, properties and applications

Tannic Acid with Antiviral and Antibacterial Activity as A Promising Component of Biomaterials—A Minireview

Photocrosslinking silver nanoparticles–aloe vera–silk fibroin composite hydrogel for treatment of full-thickness cutaneous wounds

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