The
development of silk fibroin hydrogels with a suitable gelation
rate and mechanical strength, as well as multifunctional properties
including injectability, antibacterial activity, and adhesiveness,
is of importance for wound healing and skin infection treatment, yet
their design remains challenging. Herein, a multifunctional hydrogel
from silk fibroin and tannic acid is developed, relying on the favorable
interactions between them. The hybrid hydrogel (SF-TA) exhibits numerous
advantages, such as short gelation time, low gelation concentrations,
good adhesiveness, and shear-thinning and self-recovery properties.
Moreover, the incorporation of tannic acid endows the hybrid hydrogel
with remarkable bioactivity, including antimicrobial and antioxidant
activities, beneficial to improving wound healing. In vivo experiments
verify that the designed hybrid hydrogel can significantly accelerate
the wound healing process in a full-thickness skin defect model on
mice.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.