Fabrication of micro‐patterned titanium dioxide nanotubes thin film and its biocompatibility

Xiang, Li-jie; Li, Chunhui; Yang, Ping; Li, Jingan; Huang, Nan

doi:10.1049/joe.2014.0274

Cited by 8 publications

(5 citation statements)

References 22 publications

(28 reference statements)

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“…1 b ) and a micropatterned TiO 2 nanotube surface prepared according to the method reported by us previously (the samples were labelled as NANO‐GRO, Fig. 1 c ) [21] were used as controls.…”

Section: Methodsmentioning

confidence: 99%

“…However, how to further improve blood compatibility and promote surface endothelialisation as well as inhibit hyperplasia simultaneously on the basis of TiO 2 thin film is still an urgent requirement for the clinical application of cardiovascular implanted devices. In our previous work, a micropatterned nanotube thin film was prepared which possesses anti‐coagulant, pro‐endothelialisation and anti‐hyperplasia simultaneously [21]. With this micro/nanocomposite structure, the nanotubes only distribute on the grooves of the micropattern [21]; thus the micropattern which is completely covered by the nanotubes is anticipated to improve one or more aspects of surface compatibility.…”

Section: Introductionmentioning

confidence: 99%

“…In our previous work, a micropatterned nanotube thin film was prepared which possesses anti‐coagulant, pro‐endothelialisation and anti‐hyperplasia simultaneously [21]. With this micro/nanocomposite structure, the nanotubes only distribute on the grooves of the micropattern [21]; thus the micropattern which is completely covered by the nanotubes is anticipated to improve one or more aspects of surface compatibility.…”

Section: Introductionmentioning

confidence: 99%

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Design and construction of TiO ₂ nanotubes in microarray using two‐step anodic oxidation for application of cardiovascular implanted devices

Xiang

et al. 2015

Micro & Nano Letters

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In recent years, the surface modification of biomaterials has become a hot scientific topic and has rapidly generated huge research interest in several technological areas. The fabrication of titanium dioxide (TiO 2) films and their modification for the purpose of excellent biocompatibility have been widely researched and gradually applied for cardiovascular implanted devices. In this reported work, to obtain a novel TiO 2 film that possesses anticoagulant, anti-hyperplasia and pro-endothelialisation properties simultaneously, TiO 2 nanotubes with 100 nm diameter were prepared on the microarray using a two-step anodic oxidation method. The topography of the micro/ nanocomposite TiO 2 film was investigated by scanning electron microscopy. Whole-blood experiments on the film were conducted. The number, morphology and functional factors release of endothelial cells (ECs) on the film were evaluated, and the number of smooth muscle cells (SMCs) on the film was counted. The experimental results demonstrated that the micro/nanocomposite TiO 2 film possessed excellent blood compatibility, EC, compatibility and SMC compatibility, thus suggesting potential application for cardiovascular implanted devices.

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“…1 b ) and a micropatterned TiO 2 nanotube surface prepared according to the method reported by us previously (the samples were labelled as NANO‐GRO, Fig. 1 c ) [21] were used as controls.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Design and construction of TiO ₂ nanotubes in microarray using two‐step anodic oxidation for application of cardiovascular implanted devices

Xiang

et al. 2015

Micro & Nano Letters

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“…For the platelets adhesion test, fresh whole blood of a volunteer was centrifuged at 1500 rpm for 15 min to obtain the platelet-rich plasma (PRP), then the PRP was added to the samples surfaces and incubated at 37°C for 1 h. After washed with normal saline (NS, pH = 7.4) for three times (each time 5 min), the adherent platelets were fixed with 4% paraformaldehyde at 4°C for 2 h. The morphology of the adhered platelets was examined by a Rhodamine123 staining (Sigma, USA) and observed under a fluorescence microscope (DMRX, Leica, Germany) [ 38 ]. The amounts of the adherent platelets and the activated platelets were determined by the Lactate dehydrogenase (LDH) and GMP140 assay, respectively [ 39 , 40 ].…”

Section: Materials and Experimentsmentioning

confidence: 99%

Investigation of enhanced hemocompatibility and tissue compatibility associated with multi-functional coating based on hyaluronic acid and Type IV collagen

Zhang

et al. 2016

Regen Biomater

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The biocompatibility of cardiovascular devices has always been considered crucial for their clinical efficacy. Therefore, a biofunctional coating composed of Type IV collagen (CoIV) and hyaluronan (HA) was previously fabricated onto the titanium (Ti) substrate for the application of promoting vascular smooth muscle cell contractile phenotype and improving surface endothelialization. However, the anti-inflammation property, blood compatibility and in vivo tissue compatibility of the HA/CoIV coating, as paramount consideration of cardiovascular materials surface coating, have not been investigated. Thus, in this study, the three crucial properties of the HA/CoIV coating were tested. The platelet adhesion/activation test and the dynamic whole blood experiment implied that the HA/CoIV coating had better blood compatibility compared with Ti substrate and pure CoIV coating. The macrophage adhesion/activation and inflammatory cytokine release (tumor necrosis factor-alpha and interleukin-1) results indicated that the HA/CoIV coating could significantly improve the anti-inflammation property of the Ti substrate. The in vivo implantation of SD rats for 3 weeks’ results demonstrated that the HA/CoIV coating caused milder tissue response. All these results suggested that the multi-functional HA/CoIV coating possessed good biocompatibility. This research is anticipated to be potentially applied for the surface modification of cardiovascular stents.

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“…In recent years, TiO2 has attracted wide attention for its potential application in cardiovascular implanted biomaterials [21,22]. Several studies have demonstrated that the TiO2 film possesses excellent blood compatibility and cell compatibility while its anti-hyperplasia and anti-inflammation functions need further improvement [23,24].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Cu-doped TiO2 Thin Films on Hyperplasia, Inflammation and Bacteria Infection

Zhou

et al. 2015

Applied Sciences

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In the present work, different concentrations of Cu ion (1, 2, 5 and 10 wt %) were doped in the TiO2 film by a sol-gel method and dip coating process. The morphology of the Cu-doped TiO2 films were characterized by scanning electron microscopy (SEM) and the results showed that the doped Cu made no change to the TiO2 films. The nitric oxide (NO) release experiment showed that these Cu-doped surfaces showed the ability of catalytic decomposition of exogenous donor S-nitroso-N-acetyl-penicillamine (SNAP) to generate (NO). Based on fluorescence analysis and CCK-8 quantitative results, such films had the ability to inhibit smooth muscle cells adhesion, proliferation and migration with SNAP in vitro. The macrophage adhesion assay and anti-bacterial test proved that such Cu-doped TiO2 films also possessed anti-inflammatory and anti-bacterial abilities. All the abilities above showed positive correlation with the amounts of the doped Cu. This study suggested that the Cu-doped TiO2 films were capable of generating physiological levels of NO in the presence of endogenous donor S-nitrosothiols (RSNO), endowing the TiO2 films with anti-hyperplasia, anti-inflammatory and anti-bacterial abilities.

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Fabrication of micro‐patterned titanium dioxide nanotubes thin film and its biocompatibility

Cited by 8 publications

References 22 publications

Design and construction of TiO ₂ nanotubes in microarray using two‐step anodic oxidation for application of cardiovascular implanted devices

Design and construction of TiO ₂ nanotubes in microarray using two‐step anodic oxidation for application of cardiovascular implanted devices

Investigation of enhanced hemocompatibility and tissue compatibility associated with multi-functional coating based on hyaluronic acid and Type IV collagen

The Effects of Cu-doped TiO2 Thin Films on Hyperplasia, Inflammation and Bacteria Infection

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Fabrication of micro‐patterned titanium dioxide nanotubes thin film and its biocompatibility

Cited by 8 publications

References 22 publications

Design and construction of TiO 2 nanotubes in microarray using two‐step anodic oxidation for application of cardiovascular implanted devices

Design and construction of TiO 2 nanotubes in microarray using two‐step anodic oxidation for application of cardiovascular implanted devices

Investigation of enhanced hemocompatibility and tissue compatibility associated with multi-functional coating based on hyaluronic acid and Type IV collagen

The Effects of Cu-doped TiO2 Thin Films on Hyperplasia, Inflammation and Bacteria Infection

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Design and construction of TiO ₂ nanotubes in microarray using two‐step anodic oxidation for application of cardiovascular implanted devices

Design and construction of TiO ₂ nanotubes in microarray using two‐step anodic oxidation for application of cardiovascular implanted devices