Fabrication of microneedle patches with lyophilized influenza vaccine suspended in organic solvent

Kim, Yoo Chun; Lee, Jeong Woo; Esser, E. Stein; Kalluri, Haripriya; Joyce, Jessica C.; Compans, Richard W.; Skountzou, Ioanna; Prausnitz, Mark R.

doi:10.1007/s13346-021-00927-4

Cited by 16 publications

(10 citation statements)

References 40 publications

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“…These devices performed the analysis at the micro-scale (micro-channels, micro-arrays, micro-pumps, etc. ). , The LOC integrates into one reaction platform all the processes associated with the detection, from the placement of the sample into the chip to the analysis. , One can visualize major research efforts toward developing such multifunctional MN arrays by combining electrochemical sensors and drug release actuators. In contrast to epidermal patches, the MN devices pierce and penetrate through the upper skin layers.…”

Section: Minimally Invasive Microneedle Glucose Monitoringmentioning

confidence: 99%

“…In contrast to epidermal patches, the MN devices pierce and penetrate through the upper skin layers. These consist of a plurality of micro-projections , arranged on a small patch, which is considered easier to apply/wear to replace with lesser pain than the hypodermic needle since they do not reach the pain receptors which are deep in the dermis (Figure ). Literature reveals MNs being mostly applied for minimally invasive pain-free transdermal delivery of drugs. , Over the past few years, monitoring glucose levels using MNs has gained much attention , and the MNs technology is implantable glucose sensor replaced technology to shun the biofouling effect of the sensor.…”

Section: Minimally Invasive Microneedle Glucose Monitoringmentioning

confidence: 99%

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Skin Patchable Sensor Surveillance for Continuous Glucose Monitoring

Manasa¹,

Mascarenhas²,

Shetti

et al. 2022

ACS Appl. Bio Mater.

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Diabetes mellitus is a physiological and metabolic disorder affecting millions of people worldwide, associated with global morbidity, mortality, and financial expenses. Long-term complications can be avoided by frequent, continuous self-monitoring of blood glucose. Therefore, this review summarizes the current state-of-art glycemic control regimes involving measurement approaches and basic concepts. Following an introduction to the significance of continuous glucose sensing, we have tracked the evolution of glucose monitoring devices from minimally invasive to non-invasive methods to present an overview of the spectrum of continuous glucose monitoring (CGM) technologies. The conveniences, accuracy, and cost-effectiveness of the real-time CGM systems (rt-CGMs) are the factors considered for discussion. Transdermal biosensing and drug delivery routes have recently emerged as an innovative approach to substitute hypodermal needles. This work reviews skin-patchable glucose monitoring sensors for the first time, providing specifics of all the major findings in the past 6 years. Skin patch sensors and their progressive form, i.e., microneedle (MN) array sensory and delivery systems, are elaborated, covering self-powered, enzymatic, and non-enzymatic devices. The critical aspects reviewed are material design and assembly techniques focusing on flexibility, sensitivity, selectivity, biocompatibility, and user-end comfort. The review highlights the advantages of patchable MNs' multi-sensor technology designed to maintain precise blood glucose levels and administer diabetes drugs or insulin through a "sense and act" feedback loop. Subsequently, the limitations and potential challenges encountered from the MN array as rt-CGMs are listed. Furthermore, the current statuses of working prototype glucose-responsive "closed-loop" insulin delivery systems are discussed. Finally, the expected future developments and outlooks in clinical applications are discussed.

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Section: Minimally Invasive Microneedle Glucose Monitoringmentioning

confidence: 99%

Section: Minimally Invasive Microneedle Glucose Monitoringmentioning

confidence: 99%

Skin Patchable Sensor Surveillance for Continuous Glucose Monitoring

Manasa¹,

Mascarenhas²,

Shetti

et al. 2022

ACS Appl. Bio Mater.

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“…For a drug-loaded MN, various physicochemical characterizations, including the grade of particle size, Poly dispersion index, viscosity, and zeta potential may be measured according to the type of formulation used in MNs [ 176 ]. An MN patch is complete after preprocessing for the release of drugs, adhesion, and permeation checks [ 177 ]. Dynamic light dispersion, X-ray dispersion, and transmission electron microscopy technologies allow for the characterization of MN size, inner structure, and crystallinity [ 178 ].…”

Section: Characterization Techniques For Polymeric Mnsmentioning

confidence: 99%

Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

Yadav

Munni²,

Campbell

et al. 2021

Pharmaceutics

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The ongoing search for biodegradable and biocompatible microneedles (MNs) that are strong enough to penetrate skin barriers, easy to prepare, and can be translated for clinical use continues. As such, this review paper is focused upon discussing the key points (e.g., choice polymeric MNs) for the translation of MNs from laboratory to clinical practice. The review reveals that polymers are most appropriately used for dissolvable and swellable MNs due to their wide range of tunable properties and that natural polymers are an ideal material choice as they structurally mimic native cellular environments. It has also been concluded that natural and synthetic polymer combinations are useful as polymers usually lack mechanical strength, stability, or other desired properties for the fabrication and insertion of MNs. This review evaluates fabrication methods and materials choice, disease and health conditions, clinical challenges, and the future of MNs in public healthcare services, focusing on literature from the last decade.

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“…Microneedle (MN) is a novel drug delivery system with minimally invasive manner 17 , 18 , 19 . Most previous experience with MN has demonstrated self-management and painless administration 20 , 21 , 22 . MN is a versatile platform mostly using solid MN or dissolving MN involved in the delivery of drugs or vaccines 23 , 24 , 25 , 26 .…”

Section: Introductionmentioning

confidence: 99%